Detection of human T-cell leukemia virus type I proviral sequences from fixed tissues of seropositive patients.

Abstract:

:Fixed lymphoma tissues from 11 patients seropositive for human T-cell leukemia virus type I (HTLV-I) antibodies were analyzed for proviral sequences by the polymerase chain reaction. Typical adult T-cell leukemia/lymphomas (ATLLs) from nine patients were positive for HTLV-I sequences. In contrast, one of two lymphomas with immunophenotypes atypical for ATLL was negative for HTLV-I. This HTLV-I DNA-negative lymphoma, although present in an HTLV-I-seropositive patient, was therefore reclassified. The HTLV-I tax gene was always detected in the ATLL tissues, whereas segments of the pol gene were not detected in half the cases. These studies demonstrate that fixed non-ATLL specimens can be distinguished from ATLL specimens.

journal_name

Am J Clin Pathol

authors

Shibata D,Tokunaga M,Sasaki N,Nanba K

doi

10.1093/ajcp/95.4.536

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

536-9

issue

4

eissn

0002-9173

issn

1943-7722

journal_volume

95

pub_type

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