The New Equivocal: Changes to HER2 FISH Results When Applying the 2013 ASCO/CAP Guidelines.

abstract：:Immunohistochemistry occasionally is used to determine the lineage of entirely necrotic tumors. However, the sensitivity and specificity of antibodies on necrotic tissue are unknown. To determine the usefulness of immunohistochemistry with necrotic lesions, a series of 24 known tumors consisting of 14 carcinomas, 2 ly...

journal_title：American journal of clinical pathology

authors： Judkins AR,Montone KT,LiVolsi VA,van de Rijn M

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVES:Ancillary molecular testing on tissue is available for mycobacterial disease; however, judicious use of highly sensitive tests, such as polymerase chain reaction (PCR) and sequencing, should be guided by histologic parameters. We sought to investigate the utility of performing acid-fast stains (AFS) on skin ...

journal_title：American journal of clinical pathology

authors： Laga AC,Milner DA Jr,Granter SR

更新日期：2014-04-01 00:00:00

abstract：:The aim of the present study was to determine whether micromorphometric features of positive sentinel lymph nodes (SLNs) from patients with melanoma are useful for predicting further nodal involvement in completion lymph node dissection (CLND) specimens. Of 986 patients with melanoma undergoing SLN biopsy between Marc...

journal_title：American journal of clinical pathology

authors： Scolyer RA,Li LX,McCarthy SW,Shaw HM,Stretch JR,Sharma R,Thompson JF

更新日期：2004-10-01 00:00:00

abstract：:Determination of breast cancer estrogen receptor (ER) status as a predictor of tumor response to adjuvant endocrine therapy remains a mainstay of breast cancer management. Recent second generation anti-ER antibodies and new epitope retrieval methods have produced paraffin-based immunohistochemical results that correla...

journal_title：American journal of clinical pathology

authors： Nichols GE,Frierson HF Jr,Boyd JC,Hanigan MH

更新日期：1996-09-01 00:00:00

abstract：:The expression of the cell-cycle-associated Ki-67 antigen by MIB-1 monoclonal antibody was retrospectively assessed in 35 surgically resected neuroendocrine tumor specimens of the pancreas embedded in paraffin. The MIB-1 proliferation index was correlated with the classification of the neuroendocrine tumors of the pan...

journal_title：American journal of clinical pathology

authors： Gentil Perret A,Mosnier JF,Buono JP,Berthelot P,Chipponi J,Balique JG,Cuilleret J,Dechelotte P,Boucheron S

更新日期：1998-03-01 00:00:00

abstract：:The authors describe two patients with clinically and histopathologically documented advanced (tumor) stage mycosis fungoides. In each case the large, pleomorphic neoplastic cells lacked the monoclonal antibody-defined cell surface antigens commonly associated with immature and mature T-cells, i.e., T11, Leu-1, T3, T4...

journal_title：American journal of clinical pathology

authors： Wieczorek R,Suhrland M,Ramsay D,Reed ML,Knowles DM 2nd

更新日期：1986-07-01 00:00:00

abstract：:Monoclonal antibody (MoAb) 44-3A6 recognizes a glandular differentiation-associated antigen and has been used to identify exocrine differentiation in pulmonary carcinomas. The authors assessed its value in the diagnosis of lung carcinomas metastatic to lung/pleura and pleural malignant mesothelioma (MM), using cell bl...

journal_title：American journal of clinical pathology

authors： Spagnolo DV,Whitaker D,Carrello S,Radosevich JA,Rosen ST,Gould VE

更新日期：1991-03-01 00:00:00

abstract：:We aimed to establish whether morphologic parameters were prognostically important in a large series of breast phyllodes tumors in Asian women. Of 335 phyllodes tumors diagnosed at the Department of Pathology, Singapore General Hospital, Singapore, between January 1992 and December 2002, 250 (74.6%) were benign, 54 (1...

journal_title：American journal of clinical pathology

authors： Tan PH,Jayabaskar T,Chuah KL,Lee HY,Tan Y,Hilmy M,Hung H,Selvarajan S,Bay BH

更新日期：2005-04-01 00:00:00

abstract：:The authors report the clinicopathologic features of 14 cases of amyloid goiter (AG). Eleven patients were males and three females with ages ranging from 23 to 75 years (median, 54 years). Eight patients had secondary amyloidosis and six had primary amyloidosis. Nine cases were identified at autopsy. In symptomatic pa...

journal_title：American journal of clinical pathology

authors： Hamed G,Heffess CS,Shmookler BM,Wenig BM

更新日期：1995-09-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) is a blood derivative that is being evaluated for the prevention and treatment of numerous disorders. Recent studies have suggested beneficial effects from the prophylactic administration of IVIG to very-low-birth-weight neonates. A disadvantage of such therapy is misleading infectiou...

journal_title：American journal of clinical pathology

authors： Nixon RR,Smith SA,Johnson RL,Pillers DA

更新日期：1994-03-01 00:00:00

abstract：:The combined experience of four university medical centers with fine-needle aspiration biopsy (FNAB) of the mediastinum is reviewed. This series includes 189 cases, with 100 males and 89 females, 6 months to 86 years of age. The majority (71%) of diagnoses were neoplastic with the remainder equally distributed between...

journal_title：American journal of clinical pathology

authors： Powers CN,Silverman JF,Geisinger KR,Frable WJ

更新日期：1996-02-01 00:00:00

abstract：:HER2 overexpression and amplification have been studied as a therapeutic and prognostic target in a number of human cancers, including esophageal, gastric, and colorectal adenocarcinomas. However, HER2 status has not been well investigated in primary small intestinal adenocarcinoma, probably because of its rarity. In ...

journal_title：American journal of clinical pathology

authors： Chan OT,Chen ZM,Chung F,Kawachi K,Phan DC,Himmelfarb E,Lin F,Perry A,Wang HL

更新日期：2010-12-01 00:00:00

abstract：:Anatomic pathology service is judged by accuracy of diagnosis and rapidity of reporting of that diagnosis to clinicians. Turnaround times have been used in anatomic pathology to show how long it take to produce a tissue report. Rapid tissue diagnosis is important to patients, clinicians, administrators, and anatomic p...

journal_title：American journal of clinical pathology

authors： Smith MT,Garvin AJ

更新日期：1996-10-01 00:00:00

abstract：:Whipple disease is a rare, chronic multisystem disease associated with the recently characterized organism Tropheryma whippelii. Extraintestinal manifestation involving the central nervous system, heart, and joints occasionally occurs. Involvement of the abdominal lymph nodes, especially the mesenteric and periaortic ...

journal_title：American journal of clinical pathology

authors： Alkan S,Beals TF,Schnitzer B

更新日期：2001-12-01 00:00:00

abstract：:We undertook a retrospective analysis of colonic spirochetosis in 14 cases: females, 3; males, 11; children, 4; adults, 10. Two men had HIV infections. All children and both HIV-infected men had abdominal complaints, diarrhea, or both. Most other adults underwent colonoscopy for polyp screening (n = 4) or follow-up of...

journal_title：American journal of clinical pathology

authors： Koteish A,Kannangai R,Abraham SC,Torbenson M

更新日期：2003-12-01 00:00:00

abstract：:The volume of data contained in a data warehouse represents a potential resource to provide the basis for detailed and specific reference intervals. Routine chemistry panel testing data were derived from an outreach laboratory patient population of 438,180 people and then screened by multiple data filters to identify ...

journal_title：American journal of clinical pathology

authors： Bock BJ,Dolan CT,Miller GC,Fitter WF,Hartsell BD,Crowson AN,Sheehan WW,Williams JD

更新日期：2003-11-01 00:00:00

abstract：:During a 6-month period at Walter Reed Army Hospital the monthly attack rate of Staphylococcus aureus bacteremia increased to 3.8 +/- 0.5 (mean +/- SEM) from 2.5 +/- 0.2 cases per 1,000 dispositions for the previous 48 months (P less than 0.05). A predominant phage pattern, designated S, was found in 12 (39%) of 31 ba...

journal_title：American journal of clinical pathology

authors： Cross AS,Zierdt CH,Roup B,Almazan R,Swan JC

更新日期：1983-05-01 00:00:00

abstract：:The recent clinical and commercial success of anticancer antibodies such as rituximab and trastuzumab has created great interest in antibody-based therapeutics for hematopoietic malignant neoplasms and solid tumors. Given the likelihood of lower toxic effects of antibodies that target tumor cells and have limited impa...

journal_title：American journal of clinical pathology

authors： Ross JS,Gray K,Gray GS,Worland PJ,Rolfe M

更新日期：2003-04-01 00:00:00

abstract：:We examined benign and malignant mesothelial tissue samples for the presence of X-linked inhibitor of apoptosis protein (XIAP), a potent constituent of the inhibitor of apoptosis family of caspase inhibitors. We subjected 55 sections (31 malignant mesotheliomas, 2 well-differentiated peritoneal mesotheliomas, 13 pleur...

journal_title：American journal of clinical pathology

authors： Wu M,Sun Y,Li G,Desman G,Wang B,Gil J,Burstein DE

更新日期：2007-11-01 00:00:00

abstract：:We compared the anti-estrogen receptors (ER) SP1, 6F11, and 1D5 antibodies in breast carcinoma cases with different ranges of positive cells to evaluate whether this could generate different therapies for patients. We selected 66 cases of breast cancer, each of which was immunostained with the 3 antibodies. 1D5 was le...

journal_title：American journal of clinical pathology

authors： Bogina G,Zamboni G,Sapino A,Bortesi L,Marconi M,Lunardi G,Coati F,Massocco A,Molinaro L,Pegoraro C,Venturini M

更新日期：2012-11-01 00:00:00

abstract：:The authors investigated the blast cells obtained from two patients with acute myelofibrosis with the use of recently developed immunochemical and ultrastructural markers. They intended to examine the expression of megakaryoblastic, erythroblastic, myeloblastic, and monoblastic properties in these cells. Respectively,...

journal_title：American journal of clinical pathology

authors： Schreeder MT,Prchal JT,Parmley RT,Carroll AJ,Gewirtz AM,Hoffman R

更新日期：1985-01-01 00:00:00

abstract：:Chicken pox, although common, is rarely associated with autoimmune hemolytic anemia. Reported here is the case of an 8-year-old boy who was found to have cold agglutinin disease and severe anemia several days after he contracted chicken pox. The cold agglutinin appeared to be a polyclonal immunoglobulin M antibody wit...

journal_title：American journal of clinical pathology

authors： Friedman HD,Dracker RA

更新日期：1992-01-01 00:00:00

abstract：:The blood counts and lactic dehydrogenase values of eight patients with thrombotic thrombocytopenic purpura (TTP) were reviewed in relation to the clinical course. Three of the eight patients died. In these patients, the hemoglobin was significantly lower and the LDH higher at the time of presentation than that of the...

journal_title：American journal of clinical pathology

authors： Crowley JP,Metzger JB,L'Europa RA

更新日期：1983-11-01 00:00:00

abstract：:Mucocele-like lesion (MLL) is a rare mucinous lesion of the breast with highly variable upgrade rates to atypia or malignancy on excision. This spectrum of data has led to differing opinions on the need for surgical excision. We evaluated 50 core biopsy specimens diagnosed as having MLLs and correlated the findings wi...

journal_title：American journal of clinical pathology

authors： Sutton B,Davion S,Feldman M,Siziopikou K,Mendelson E,Sullivan M

更新日期：2012-12-01 00:00:00

abstract：:In situ hybridization with specific RNA radiolabeled probes was used to analyze the production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) by 21 low-grade follicular lymphomas (FLs). All of the 21 FLs tested contained lymphokine-synthesizing cells in the interfollicular and follicular areas. Enumeration o...

journal_title：American journal of clinical pathology

authors： Peuchmaur M,Emilie D,Crevon MC,Brousse N,Gaulard P,D'Agay MF,Galanaud P,Solal-Celigny P

更新日期：1991-01-01 00:00:00

abstract：:A multiplex polymerase chain reaction (PCR) assay using oligonucleotide primers to detect mecA and 16S ribosomal RNA gene was developed to aid in identification of methicillin-resistant staphylococci. Validation included 99 isolates of staphylococcus grouped into one of five categories: methicillin-susceptible coagula...

journal_title：American journal of clinical pathology

authors： Salisbury SM,Sabatini LM,Spiegel CA

更新日期：1997-03-01 00:00:00

abstract：:Automation was introduced into the clinical microbiology laboratory in the 1960s but initially met with limited success. Today, instruments are an integral part of many clinical laboratories and are used for microbial detection, identification, and susceptibility testing; detection of positive blood cultures; screenin...

journal_title：American journal of clinical pathology

authors： Woods GL

更新日期：1992-10-01 00:00:00

abstract：:Serum creatine kinase (CK) was measured in 515 healthy white women and 28 obligate carriers for Duchenne muscular dystrophy. There was substantial overlap between the control and carrier populations. To analyze the impact of the degree of overlap, the predictive value of a CK result was determined by (1) using sensiti...

journal_title：American journal of clinical pathology

authors： Gruemer HD,Miller WG,Chinchilli VM,Leshner RT,Blasco PA,Hassler CR,Nance WE

更新日期：1985-11-01 00:00:00

abstract：:Five hundred consecutive isolates of viridans streptococci were identified to the species level in an effort to determine their distribution and incidence in routine clinical specimens. Viridans streptococci accounted for significant percentages of streptococcal isolates from urine, wounds, body fluids, and blood. The...

journal_title：American journal of clinical pathology

authors： Ruoff KL,Fishman JA,Calderwood SB,Kunz LJ

更新日期：1983-12-01 00:00:00

abstract：:Immunohistochemical study of smooth muscle myosin, a protein distinct from skeletal, cardiac, or nonmyogenous myosins in paraffin-embedded normal tissues and benign and malignant mesenchymal tumors revealed its strong expression in normal smooth muscle, capillary endothelium, and pericytes. All benign smooth muscle tu...

journal_title：American journal of clinical pathology

authors： Donner L,de Lanerolle P,Costa J

更新日期：1983-11-01 00:00:00