Abstract:
:A 28-month-old girl, whose parents are first cousins, was hospitalized following a series of severe infections. Results of functional granulocytic tests permitted the diagnosis of chronic granulomatous disease (lack of nitroblue tetrazolium dye reduction, impaired bactericidal activity for Staphylococcus aureus but normal activity for Streptococcus foecalis). Random migration was also impaired, and leukocytic glucose-6-phosphate dehydrogenase (G6PD) activity was decreased (37% of the normal mean). In contrast, erythrocytic G6PD activity was normal. Similar leukocytic studies of both parents revealed a moderate decrease of the mother's leukocytic G6PD activity (62% of the normal mean). This case represents an additional argument in favor of the recessive autosomal transmission of chronic granulomatous disease in females.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Corberand J,De Larrard B,Vergnes H,Carrière JPdoi
10.1093/ajcp/70.2.296subject
Has Abstractpub_date
1978-08-01 00:00:00pages
296-300issue
2eissn
0002-9173issn
1943-7722journal_volume
70pub_type
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journal_title:American journal of clinical pathology
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更新日期:1985-04-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1985-05-01 00:00:00
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更新日期:2007-12-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1979-12-01 00:00:00
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