Terminal diffuse alveolar damage in relation to interstitial pneumonias. An autopsy study.

Abstract:

:Acute exacerbations of idiopathic pulmonary fibrosis/cryptogenic fibrosing alveolitis (IPF/CFA) are rare and typically terminal events, but their relationship to underlying patterns of idiopathic interstitial pneumonias is unknown. We reviewed autopsy material from patients who died of diffuse alveolar damage in the clinical setting of pulmonary fibrosis, both idiopathic and with background fibrosing alveolitis with connective tissue disorders (FA-CTDs), and compared them with cases of acute interstitial pneumonia. Of 15 patients with acute exacerbations of IPF/CFA (n = 12) or FA-CTD (n = 3), 12 had a background pattern of usual interstitial pneumonia and 3 had fibrotic nonspecific interstitial pneumonia. All cases of fibrotic nonspecific interstitial pneumonia were seen in association with FA-CTD. The cause of acute exacerbations is unknown, but our data suggest that toxic effects of oxygen and triggering infection are unlikely causes. In patients with CTDs, it remains uncertain whether the acute exacerbation is related to the fibrosis, the associated CTD, or a combination of these factors. Acute exacerbations of IPF/CFA may be a more common terminal event than previously thought.

journal_name

Am J Clin Pathol

authors

Rice AJ,Wells AU,Bouros D,du Bois RM,Hansell DM,Polychronopoulos V,Vassilakis D,Kerr JR,Evans TW,Nicholson AG

doi

10.1309/UVAR-MDY8-FE9F-JDKU

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

709-14

issue

5

eissn

0002-9173

issn

1943-7722

journal_volume

119

pub_type

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