Abstract：
:Serum bicarbonate testing has been reported to be inaccurate in several clinical studies. This prompted a search for systemic errors in bicarbonate testing devices, which has been inconclusive. The effect on serum bicarbonate level measurement of partially filling plain red-top (clot) vacutainer tubes was studied in healthy volunteers. First, 10-mL vacutainers were filled with 9.5 mL, 6 mL, 3 mL, and 1 mL of identical blood. Second, pediatric (3 mL) vacutainers were filled with 3 mL, 1 mL, and 0.5 mL of identical blood. The serum bicarbonate level was measured on an automated stat analyzer. Linear regression with dummy variables for subjects showed a significant reduction in bicarbonate reading as volume in the vacutainer decreased. Consistent decrease was noted regardless of whether samples were analyzed immediately after clotting (10 minutes) or at 20, 30, and 40 minutes after withdrawal of blood. This decrease was evident regardless of whether blood was aspirated directly into a vacutainer or first aspirated into a syringe and injected into a vacutainer. Underfilling of vacutainers may account for low bicarbonate readings and thus vacutainers should be filled completely to obtain accurate measurements of serum bicarbonate levels.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Herr RD,Swanson Tdoi
10.1093/ajcp/97.2.213subject
Has Abstractpub_date
1992-02-01 00:00:00pages
213-6issue
2eissn
0002-9173issn
1943-7722journal_volume
97pub_type
杂志文章abstract：:Estrogen and progesterone receptors were studied in fine-needle aspiration biopsy specimens of 56 patients with primary, recurrent, or metastatic breast carcinoma. The ligands, 17 B-estradiol-6-carboxymethyloxine-bovine serum albumin fluorescein isothiocyanate (FITC-BSA estradiol) and hydroxyprogesterone hemisuccinate...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/95.1.35
更新日期：1991-01-01 00:00:00
abstract：:A flow cytometric technic was developed to detect platelet surface-bound immunoglobulin in patients with thrombocytopenia. Elevated platelet surface IgG and/or IgM was detected in 90.9% of patients with immune thrombocytopenia purpura (ITP). False positive results occurred in 9.3% of patients with nonimmune thrombocyt...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/87.4.518
更新日期：1987-04-01 00:00:00
abstract：:Establishment of a procedure termed cerebrospinal fluid (CSF) TRAP ("Transport and Rapid Accessioning for Additional Procedures") allows clinicians to appropriately store, at -75 degrees C, and rapidly access CSF specimens. The CSF TRAP enhances patient care by decreasing the need for repeat lumbar punctures and provi...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/90.6.707
更新日期：1988-12-01 00:00:00
abstract：OBJECTIVES:To evaluate the expression of progesterone receptor (PR), estrogen receptor (ER), and G protein-coupled estrogen receptor 1 (GPER-1) in cutaneous neurofibromas (cNFs) and their correlation with demographic, clinical, and laboratory data of individuals with neurofibromatosis 1 (NF1). The association of PROGIN...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/aqaa186
更新日期：2020-12-08 00:00:00
abstract：:We report 2 cases of splenic postchemotherapy histiocyte-rich pseudotumor. Each patient had a history of diffuse large B-cell lymphoma, treated with multiagent chemotherapy. Computed tomography scans performed on both patients showed splenic masses. A positron emission tomography scan performed on 1 patient showed inc...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCPC67QOGJXCEZB
更新日期：2009-09-01 00:00:00
abstract：:Anaplastic large cell lymphoma (ALCL) is clinically and pathologically heterogeneous, leading to some difficulty in its diagnosis and acceptance as a specific entity. ALCL can be subdivided into different groups according to histologic features (pleomorphic, monomorphic, small cell predominant, Hodgkin's disease-relat...
journal_title：American journal of clinical pathology
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：:Because T-regulatory cells (Tregs) can harmfully impair HIV-specific responses or beneficially limit immune activation, we compared the number of Tregs in lymph nodes from 48 HIV+ patients and 106 HIV- subjects. By using a microscope counting grid, we found that the mean ± SD number of Tregs in lymph nodes was 3 times...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCPAR39BFWNHWRO
更新日期：2011-07-01 00:00:00
abstract：:This is a report of an adenocarcinoma of mesonephric origin studied by light microscopy, electron microscopy, and immunocytochemistry. Unlike previous reports, our lesion was located paravaginally and not in the leaves of the broad ligament or in the cervix. The light microscopic features are similar to those of previ...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/80.4.539
更新日期：1983-10-01 00:00:00
abstract：:The frequency with which blood gas measurements should be obtained is controversial because laboratory-based blood gas analyzers impose blood loss, delay, and cost on each measurement. Point-of-care analyzers eliminate the delay factor, but blood loss and cost factors remain. Optode microsensing can be adopted readily...
journal_title：American journal of clinical pathology
pub_type： 杂志文章,评审
doi：
更新日期：1995-10-01 00:00:00
abstract：:A number of reports have highlighted discrepancies between the DuPont aca and fibrometer-based methods for quantitating plasma fibrinogen levels. Although many authors have suggested that the presence of fibrin(ogen) degradation products are in some way responsible for the discrepancies, no direct test of this hypothe...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/88.4.490
更新日期：1987-10-01 00:00:00
abstract：:Chronic lymphocytic leukemia (CLL) is well characterized clinically and immunophenotypically. Demonstration of a monotypic CD19+, CD5+ B-cell population is central to the diagnosis. We report 2 cases of biclonal CLL. Two elderly men were encountered with an absolute lymphocytosis consisting of the typical CD5+, CD19+,...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/V8AN-A2XP-7TDV-HR0T
更新日期：2000-06-01 00:00:00
abstract：:Location-guided screening in cervical cytology offers a potentially significant advance over routine manual screening. A prospective, 2-armed, masked clinical trial of the BD FocalPoint GS Imaging System using SurePath slides (BD Diagnostics-TriPath, Burlington, NC) compared routine manual screening and quality contro...
journal_title：American journal of clinical pathology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1309/AJCP8VE7AWBZCVQT
更新日期：2009-11-01 00:00:00
abstract：:We studied methylation of 2 tumor suppressor genes (p14, p16) and 4 MINT (methylated in tumor) clones (MINT1, MINT2, MINT25, MINT31) among 51 fundic gland polyps (FGPs) and 27 normal gastric body biopsy samples using bisulfite treatment of genomic DNA followed by methylation-specific polymerase chain reaction. Thirty-...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/4QUN-J4F2-7QK7-RR0G
更新日期：2004-11-01 00:00:00
abstract：:The overall performances of several enzyme reagent kits for alkaline phosphatase, creatine kinase, lactic dehydrogenase, and aspartate aminotransferase were evaluated using an ABA-100 Bichromatic Analyzer. Interassay precision using this instrument with commercial reagents compared well with published data for similar...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/72.2.151
更新日期：1979-08-01 00:00:00
abstract：OBJECTIVES:Edoxaban, an oral direct factor Xa inhibitor, does not require routine monitoring. However, assessment of the anticoagulant effects may be required in certain situations. METHODS:We investigated the effects of edoxaban on prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin gene...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCPQ2NJD3PXFTUG
更新日期：2015-02-01 00:00:00
abstract：:The purpose of our study was to clarify the prognosis of lymphoepithelioma-like carcinoma (LELC) of the lung, which is rare. We analyzed the clinicopathologic features of 32 cases of pulmonary LELC and compared the cases with 84 cases of pulmonary non-LELC with available long-term follow-up information. The results sh...
journal_title：American journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1309/BUAN-BGFW-69U9-C3H8
更新日期：2001-06-01 00:00:00
abstract：:We describe the development and testing of a novel pre-sign-out quality assurance tool for case diagnoses that allows for the random review of a percentage of cases by a second pathologist before case verification and release of the final report. The tool incorporates the ability to record and report levels of diagnos...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCPLN9DU9LNXSXA
更新日期：2010-06-01 00:00:00
abstract：:Considerable progress has been achieved in our knowledge of the function of the chemokine system and in understanding its role in the pathophysiology of human diseases. This complex system, presently including approximately 50 cytokines and 20 receptors, coordinates leukocyte recruitment in a variety of human diseases...
journal_title：American journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1309/M6U4B8L6TNAK4G9L
更新日期：2005-06-01 00:00:00
abstract：:Point-of-care testing (POCT) is a means of providing patient services more rapidly. Most evaluations of bedside laboratory testing devices have emphasized analytical performance in tertiary care settings. In contrast, the authors compare the operating cost of POCT for glucose and an electrolyte/glucose/blood urea nitr...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/103.2.240
更新日期：1995-02-01 00:00:00
abstract：:The blood counts and lactic dehydrogenase values of eight patients with thrombotic thrombocytopenic purpura (TTP) were reviewed in relation to the clinical course. Three of the eight patients died. In these patients, the hemoglobin was significantly lower and the LDH higher at the time of presentation than that of the...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/80.5.700
更新日期：1983-11-01 00:00:00
abstract：:Several authors have suggested that a plausible mechanism for variation in reported mean corpuscular volume (MCV) and hematocrit values for Hematology Survey Specimens may be due to the presence of hyperglycemia in the suspending matrix of the specimens, resulting in cell swelling due to an osmotic matrix effect. The ...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：:Mycobacterium leprae causes leprosy. M leprae strains collected worldwide have been genetically clonal, which poorly explains the varying severity and clinical features of the disease. We discovered a new Mycobacterium species from 2 patients who died of diffuse lepromatous leprosy (DLL). The Mycobacterium was purifie...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCPP72FJZZRRVMM
更新日期：2008-12-01 00:00:00
abstract：:DRC (dendritic reticulum cell) antigen expression was studied in 38 cases of B-cell lymphomas including follicular lymphoma. The results of this study showed DRC-1 to be expressed in 1/3 of small lymphocytic; 3/3 of mantle zone lymphoma (MZL); 10/10 of follicular, small cleaved; 6/7 of follicular, mixed; 1/2 of follic...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/89.4.488
更新日期：1988-04-01 00:00:00
abstract：:Venous thromboembolism (VTE) results from the interaction of the Virchow triad (venous stasis, endothelial injury, and hypercoagulability). Risk factors for increased hypercoagulability, or thrombophilia, include activated protein C resistance/factor V Leiden, the prothrombin G20210A mutation, deficiencies of the natu...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCP5SQT3ZKYQFBM
更新日期：2012-04-01 00:00:00
abstract：:Hematogones (HGs) comprise a B-lineage lymphoid precursor cell population in the bone marrow (BM) that may simulate acute lymphoblastic leukemia or lymphoma. Increased numbers of HGs have been noted in children, but few reports describe their occurrence in adults. We identified 13 adult patients with significant numbe...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/102.2.202
更新日期：1994-08-01 00:00:00
abstract：:Previous studies suggest that low prostate weight is a significant negative prognostic factor for prostate cancer. In the current study, the data for 431 men who underwent radical retropubic prostatectomy between 1990 and 1998 were analyzed for association between prostate weight and various clinical and pathologic pa...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCPPHGXDI94SGAC
更新日期：2010-04-01 00:00:00
abstract：:The authors report two cases of vernix caseosa peritonitis, an infrequent complication of cesarean section with distinctive histopathologic findings. Both patients underwent exploratory laparotomy for unexplained abdominal pain after cesarean section. Histopathologic evaluation of surgically removed tissue revealed an...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/103.6.681
更新日期：1995-06-01 00:00:00
abstract：:A nodule of the liver was incidentally noted during left colectomy for a large villous adenoma in a 74-year-old man. Microscopic examination disclosed a granuloma of the liver containing numerous Enterobius vermicularis ova and a cross-section of the nematode. This is the fourth reported case of hepatic oxyuriasis and...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/91.1.97
更新日期：1989-01-01 00:00:00
abstract：:In order to further clarify the histologic criteria and prognostic measurement of appendiceal adenoma and well differentiated adenocarcinoma, lectin binding activity in 31 cases of appendiceal mucocele (6 hyperplasias, 16 adenomas and 9 adenocarcinomas) was studied using an immunoperoxidase staining method. An additio...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/89.4.481
更新日期：1988-04-01 00:00:00
abstract：:A case is presented of an anterior mediastinal mass arising in a 64-year-old woman that showed on histologic, immunopathologic, and ultra-structural examination features of a poorly differentiated (insular) thyroid carcinoma. The tumor in this patient most likely arose from ectopically displaced thyroid tissue on the ...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/104.4.408
更新日期：1995-10-01 00:00:00
