Napsin A expression in primary mucin-producing adenocarcinomas of the lung: an immunohistochemical study.

Abstract:

:Immunohistochemical expression of napsin A in primary pulmonary mucinous tumors is not well established. Napsin A immunoreactivity was evaluated in 43 mucin-producing adenocarcinomas of the lung consisting of 18 tumors formerly classified as mucinous bronchioloalveolar carcinoma, 15 colloid adenocarcinomas, 5 solid predominant adenocarcinomas with mucin production, and 5 adenocarcinomas with signet ring cell features, as well as in 25 extrapulmonary mucinous adenocarcinomas of different anatomic sites. Immunohistochemical expression of thyroid transcription factor 1 (TTF-1) was also compared. Thirty-three percent of mucinous lung tumors exhibited positive immunoreactivity for napsin A, whereas 42% expressed TTF-1. All 25 extrapulmonary mucinous adenocarcinomas lacked expression of napsin A and TTF-1. Mucin-producing neoplasms of the lung infrequently express napsin A, suggesting that immunohistochemical assessment of napsin A may have limited diagnostic usefulness for distinguishing primary and metastatic mucinous adenocarcinomas involving the lung.

journal_name

Am J Clin Pathol

authors

Wu J,Chu PG,Jiang Z,Lau SK

doi

10.1309/AJCP62WJUAMSZCOM

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

160-6

issue

2

eissn

0002-9173

issn

1943-7722

pii

139/2/160

journal_volume

139

pub_type

杂志文章
  • Influence of blood collection systems on the prothrombin time and international sensitivity index determined with human and rabbit thromboplastin reagents.

    abstract::Three brands of blood collection tubes were studied for their influence on the prothrombin time (PT) and international sensitivity index (ISI) for 5 commercial thromboplastin reagents. With all reagents, PTs were shorter in Vacutainer (Becton Dickinson Vacutainer Systems, Plymouth, England) samples than in S-Monovette...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/NW194EAMD4WMEHJD

    authors: van den Besselaar AM,Hoekstra MM,Witteveen E,Didden JH,van der Meer FJ

    更新日期:2007-05-01 00:00:00

  • Hematogones in the bone marrow of adults. Immunophenotypic features, clinical settings, and differential diagnosis.

    abstract::Hematogones (HGs) comprise a B-lineage lymphoid precursor cell population in the bone marrow (BM) that may simulate acute lymphoblastic leukemia or lymphoma. Increased numbers of HGs have been noted in children, but few reports describe their occurrence in adults. We identified 13 adult patients with significant numbe...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/102.2.202

    authors: Davis RE,Longacre TA,Cornbleet PJ

    更新日期:1994-08-01 00:00:00

  • Immunocytochemical demonstration of neuron-specific enolase (NSE) in human lung cancers.

    abstract::An anti-serum against human neuron-specific enolase (NSE), raised in sheep, has been characterized and used for immunocytochemical localization of NSE in paraffin sections of normal tissues and lung cancers. Of the small cell carcinomas (SCC), 69 out of 99 (70%) cases stained with the anti-serum. Maltreated biopsies s...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.1.1

    authors: Bergh J,Esscher T,Steinholtz L,Nilsson K,Påhlman S

    更新日期:1985-07-01 00:00:00

  • Oxidized-LDL/beta(2)-glycoprotein I complexes are associated with disease severity and increased risk for adverse outcomes in patients with acute coronary syndromes.

    abstract::Oxidized low-density lipoprotein (oxLDL)/beta(2)-glycoprotein I (beta2GPI) complexes have been implicated in atherogenesis. oxLDL/beta2GPI complexes were measured in 339 patients with suspected acute coronary syndromes. Approximately 68% had angiographically documented coronary artery disease (CAD) and significantly h...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP88WVRDRDFBAS

    authors: Greco TP,Conti-Kelly AM,Anthony JR,Greco T Jr,Doyle R,Boisen M,Kojima K,Matsuura E,Lopez LR

    更新日期:2010-05-01 00:00:00

  • Morphonuclear relationship between prostatic intraepithelial neoplasia and cancers as assessed by digital cell image analysis.

    abstract::Using digital cell image analysis performed on Feulgen-stained nuclei, the nuclear characteristics of prostatic neoplasia, ranging from benign (benign prostatic hyperplasia [BPH]), through dysplastic (prostatic intraepithelial neoplasia [PIN] 1-3), to carcinoma were studied. Four histopathologic groups were studied: g...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/96.5.628

    authors: Petein M,Michel P,van Velthoven R,Pasteels JL,Brawer MK,Davis JR,Nagle RB,Kiss R

    更新日期:1991-11-01 00:00:00

  • Comparative performance of three anti-factor Xa heparin assays in patients in a medical intensive care unit receiving intravenous, unfractionated heparin.

    abstract::The availability of automated anti-Xa heparin assays provides the opportunity to manage patient unfractionated heparin levels directly, rather than by the activated partial thromboplastin time. Because critically ill patients can acquire an antithrombin deficiency, we compared the performance of 3 anti-Xa heparin assa...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/8E3U7RXEPXNP27R7

    authors: Lehman CM,Rettmann JA,Wilson LW,Markewitz BA

    更新日期:2006-09-01 00:00:00

  • Prediction of carrier status in Duchenne dystrophy by creatine kinase measurement.

    abstract::Serum creatine kinase (CK) was measured in 515 healthy white women and 28 obligate carriers for Duchenne muscular dystrophy. There was substantial overlap between the control and carrier populations. To analyze the impact of the degree of overlap, the predictive value of a CK result was determined by (1) using sensiti...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.5.655

    authors: Gruemer HD,Miller WG,Chinchilli VM,Leshner RT,Blasco PA,Hassler CR,Nance WE

    更新日期:1985-11-01 00:00:00

  • Theory and applications of the polymerase chain reaction.

    abstract::The polymerase chain reaction (PCR) is a newly developed molecular biology technique that can significantly amplify DNA or RNA. The process consists of repetitive cycles of specific DNA synthesis, defined by short stretches of preselected DNA. With each cycle, there is a doubling of the final, desired DNA product such...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:

    authors: Remick DG,Kunkel SL,Holbrook EA,Hanson CA

    更新日期:1990-04-01 00:00:00

  • Serum alpha-fetoprotein. A prognostic indicator of liver-cell necrosis and regeneration following experimental injury by galactosamine in rats.

    abstract::The serum concentrations of alpha-fetoprotein of rats following experimental galactosamine-induced liver-cell necrosis accurately reflect the severity of preceding liver-cell damage as determined by elevation of serum transaminases. There is a very close correlation between the highest SGOT or SGPT serum activity foun...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/66.5.847

    authors: Sell S,Stillman D,Gochman N

    更新日期:1976-11-01 00:00:00

  • In vitro detection of mild inhibitors to factor VIII in hemophilia.

    abstract::Plasma samples from patients with severe classic hemophilia, suspected of having mild inhibitors not detected in the standard Bethesda inhibitor test, were examined in modified Bethesda tests and in a screening test based on the activated partial thromboplastin time (APTT). The APTT test was more sensitive to mild inh...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/77.6.749

    authors: Ewing NP,Kasper CK

    更新日期:1982-06-01 00:00:00

  • Non-Hodgkin's lymphomas of the sinonasal region: histologic subtypes and their clinicopathologic features.

    abstract::The authors describe 11 patients with non-Hodgkin's lymphoma arising in the nasal cavity or paranasal sinuses. Seven were men and four were women. The median age of the women was 76 years; the median age of the men was 45 years. The most common presenting symptoms were nasal obstruction and unilateral facial swelling....

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.6.721

    authors: Frierson HF Jr,Mills SE,Innes DJ Jr

    更新日期:1984-06-01 00:00:00

  • Factor VIII-related antigen staining by immunoperoxidase technic in smaller laboratories: a potential problem.

    abstract::A case of metastatic squamous cell carcinoma to bone was studied using immunoperoxidase methods for Factor VIII-related antigen, producing positive staining in the tumor cells. Electron microscopy proved the squamous nature of the tumor, and, subsequently, a pulmonary primary tumor was found. Testing of additional tum...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.1.117

    authors: Wilson AJ

    更新日期:1984-01-01 00:00:00

  • Double immunostaining of lymph node sections by monoclonal antibodies using phycoerythrin labeling and haptenated reagents.

    abstract::Double immunostaining of tissue sections by monoclonal antibodies has been performed using, in immunofluorescence, combinations of reagents conjugated with different fluorochromes. These were monoclonal antibodies directly labeled with phycoerythrin (a new red fluorochrome) and haptenated monoclonal antibodies detecte...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/82.1.44

    authors: Pizzolo G,Chilosi M

    更新日期:1984-07-01 00:00:00

  • Detection of cryptococcal polysaccharide using counterimmunoelectrophoresis.

    abstract::Counterimmunoelectrophoresis was used to detect Cryptococcus neoformans capsular polysaccharide in the body fluids of infected patients. Using rabbit anti-C. neoformans A15 globulin, counterimmunoelectrophoresis detected 1.25 microgram of purified cryptococcal polysaccharide per ml of cerebrospinal fluid (CSF) or urin...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/68.1.39

    authors: Maccani JE

    更新日期:1977-07-01 00:00:00

  • Use of viral cultures and serologic tests for cytomegalovirus infection. Rational or random?

    abstract::To assess their applied clinical utility, viral cultures and serological tests for cytomegalovirus (CMV) were reviewed at Duke University Medical Center (DUMC), a 1,125-bed tertiary-care hospital. Less than 1% (3 of 1,216) of CMV cultures were positive, and 8% of serum samples (45 of 587) were positive by single sera ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/106.2.180

    authors: Mangano WE,Gruninger RP

    更新日期:1996-08-01 00:00:00

  • Usefulness of Dual Immunohistochemistry Staining in Detection of Hairy Cell Leukemia in Bone Marrow.

    abstract:OBJECTIVES:We evaluated efficacy of two dual immunohistochemistry (IHC) staining assays in assessing hairy cell leukemia (HCL) involvement in core biopsies and compared the results with concurrently collected flow cytometric data. METHODS:Overall, 148 patients with HCL (123 male, 25 female; mean age: 59.8 years; range...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqz171

    authors: Gupta GK,Sun X,Yuan CM,Stetler-Stevenson M,Kreitman RJ,Maric I

    更新日期:2020-02-08 00:00:00

  • Incidence of diagnostic change in colorectal polyp specimens after deeper sectioning at 2 different laboratories staffed by the same pathologists.

    abstract:OBJECTIVES:To calculate the incidence of nondiagnostic (ND) colorectal (CR) polyp cases in which deeper tissue sectioning rendered new diagnostic information--particularly adenomas--in 2 laboratories staffed by the same pathologists. METHODS:After initial diagnosis, 100 ND CR polyps from each laboratory were reexamine...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPPXU66QZAZNYN

    authors: Nielsen JA,Lager DJ,Lewin M,Weber JJ,Roberts CA

    更新日期:2013-08-01 00:00:00

  • An analysis of the relationship between a pathology department and its laboratory information system vendor.

    abstract::The ongoing collaborative relationship between a pathology department and the vendor of its laboratory information system is vitally important because of the strategic importance of the laboratory information system in managing the information product of the department. Laboratory information system vendors are value-...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/97.3.363

    authors: Friedman BA,Mitchell W

    更新日期:1992-03-01 00:00:00

  • Molecular and clinicopathologic characterization of AML with isolated trisomy 4.

    abstract::Acute myeloid leukemia (AML) with isolated trisomy 4 is rare. Associations with KIT mutations on chromosome 4q12 have been documented. The clinicopathologic features and mutational status of KIT, FLT3, NPM1, CEBPA, and RAS were assessed in 13 AML cases with isolated trisomy 4. There were 9 men and 4 women with a media...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP7ZC9YQERSKGX

    authors: Bains A,Lu G,Yao H,Luthra R,Medeiros LJ,Sargent RL

    更新日期:2012-03-01 00:00:00

  • The effect of media and temperature on the storage of Chlamydia trachomatis.

    abstract::Four media, Eagle's minimal essential medium with 10% fetal bovine serum (MEM/FBS), tryptic soy broth (TSB), 2-SP, and 4-SP, were compared for their ability to maintain the viability of Chlamydia trachomatis at 4 degrees C, -20 degrees C, -70 degrees C, and -176 degrees C (liquid nitrogen) over a 1-week period. 2-SP m...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.2.237

    authors: Aarnaes SL,Peterson EM,De La Maza LM

    更新日期:1984-02-01 00:00:00

  • Ischemia-modified albumin improves the usefulness of standard cardiac biomarkers for the diagnosis of myocardial ischemia in the emergency department setting.

    abstract::We studied the role of ischemia-modified albumin (IMA) with standard biomarkers (myoglobin, creatine kinase-MB [CK-MB], troponin I [TnI]) in assessment of 200 patients with suspected myocardial ischemia admitted to the emergency department. Every case was reviewed by a cardiologist. A clinical diagnosis of ischemia wa...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/4bctg5ucymqfwblr

    authors: Anwaruddin S,Januzzi JL Jr,Baggish AL,Lewandrowski EL,Lewandrowski KB

    更新日期:2005-01-01 00:00:00

  • Pleomorphic adenoma (benign mixed tumor) of the breast. An immunohistochemical, flow cytometric, and ultrastructural study and review of the literature.

    abstract::Pleomorphic adenoma (or benign mixed tumor) of the breast is a rare benign neoplasm that might be misinterpreted both clinically and pathologically as a malignant tumor. The authors present an additional case of this unusual lesion studied by immunohistochemistry, electron microscopy, and flow cytometry. A 77-year-old...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1093/ajcp/93.6.795

    authors: Ballance WA,Ro JY,el-Naggar AK,Grignon DJ,Ayala AG,Romsdahl MG

    更新日期:1990-06-01 00:00:00

  • A diagnostic expert system for colonic lesions.

    abstract::The diagnostic expert system for colonic lesions (DESCL) was designed to discriminate colonic adenoma and adenocarcinoma from normal colonic tissue. Although it was originally developed for use in conjunction with a machine vision analytic system, the DESCL has evolved into a teaching tool and a model for conceptual m...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:

    authors: Graham AR,Paplanus SH,Bartels PH

    更新日期:1990-10-01 00:00:00

  • Racial differences in vitamin B12 levels in the United States.

    abstract::Studies from Africa have demonstrated that black people have higher vitamin B12 (cobalamin) levels than do white people. The authors compared healthy white people, black people, and Latin-Americans in the United States. Their study is also the largest in which the effect of race and sex on the cobalamin levels has bee...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/88.1.95

    authors: Saxena S,Carmel R

    更新日期:1987-07-01 00:00:00

  • Gonadoblastoma with tubal pregnancy.

    abstract::A case of unilateral gonadoblastoma in association with a ruptured ectopic tubal pregnancy is presented. The patient had normal menstrual history prior to a missed period followed by abdominal pain and the passage of clots. The surgical specimens, in addition to the ruptured tubal pregnancy, showed nodular foci of typ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/65.1.121

    authors: Pratt-Thomas HR,Cooper JM

    更新日期:1976-01-01 00:00:00

  • Gastric non-Hodgkin lymphomas of mucosa-associated lymphoid tissue are not associated with more aggressive Helicobacter pylori strains as identified by CagA.

    abstract::Primary gastric non-Hodgkin lymphoma of mucosa-associated lymphoid tissue (MALT-NHL) is strongly related to Helicobacter pylori (H pylori) infection. CagA positive H pylori strains appear to be more aggressive, as reflected by a greater degree of gastric inflammation and higher levels of Il-8 production. Using a polym...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/106.5.670

    authors: de Jong D,van der Hulst RW,Pals G,van Dijk WC,van der Ende A,Tytgat GN,Taal BG,Boot H

    更新日期:1996-11-01 00:00:00

  • Bacteremia and postmortem microbiology in burned children.

    abstract::During a three-year period, Staphylococcus aureus and Pseudomonas aeruginosa were the organisms most commonly isolated from blood cultures of burned children. Microorganisms were considered to contribute to the cause of death in 17 of 20 patients who died from various complications of thermal injuries. Pseudomonas aer...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/63.4.502

    authors: Smith RF,Linares HA,Jorgensen JH

    更新日期:1975-04-01 00:00:00

  • Direct and indirect immunofluorescence as a diagnostic adjunct in the interpretation of nonneoplastic medical lung disease.

    abstract::Fresh open lung biopsy material from 57 patients was incubated with fluoresceinated complement and immunoglobulin antisera. An indirect immunofluorescent assay using neonatal lung as substrate was conducted as well. Direct immunofluorescent patterns could be categorized into interalveolar septal capillary deposition, ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/EHUQ-HW6K-0G41-E0DX

    authors: Magro CM,Morrison C,Pope-Harman A,Rothrauff SK,Ross P Jr

    更新日期:2003-02-01 00:00:00

  • Non-Hodgkin's lymphoma following Hodgkin's disease. A case report and immunohistochemical corroboration.

    abstract::Two non-Hodgkin's lymphomas, one a follicular mixed cell type and the other a diffuse large cell type (Working Formulation), appeared 7 and 12 years, respectively, after the initial histopathologic diagnosis of Hodgkin's disease (nodular sclerosis) in an elderly male. The clinicopathologic implications of non-Hodgkin'...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/86.3.370

    authors: Shimizu K,Hara K,Kunii A

    更新日期:1986-09-01 00:00:00

  • Use of commercially prepared control sera as quality control materials for spectrophotometric bilirubin determinations in amniotic fluid.

    abstract::The visible absorption spectra of dilutions of commercially prepared chemistry control sera closely mimic those of jaundiced amniotic fluids in cases of fetal rhesus isoimmunization. The authors have assessed the use of these materials for the quality control of net absorbance measurements at 450 nm on amniotic fluids...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.4.513

    authors: McDonald OL,Watts MT

    更新日期:1985-10-01 00:00:00