Number of Intratumoral T Lymphocytes Is Associated With Lymph Node Size, Lymph Node Harvest, and Outcome in Node-Negative Colon Cancer.

Abstract:

OBJECTIVES:We postulated that lymph node (LN) harvest and LN size are influenced by immunologic effects. METHODS:To investigate this hypothesis, we performed a retrospective analysis of 170 node-negative colon cancer cases to evaluate the density of intratumoral T lymphocytes (ITLs). CD3- and CD8-positive T cells were counted using a digital system. RESULTS:The ITL density was significantly increased in cases with sufficient LN harvest and high numbers of LNs larger than 5 mm (LN5). High ITL numbers were associated with improved cancer-specific survival. The analysis of the immune score revealed a significantly different cancer-specific outcome (P = .024), with no cancer-related death in the group with the highest score. The immune score and tumor budding were independently prognostic. CONCLUSIONS:ITL density is independently prognostic and associated with LN harvest and LN size. The immune response is very likely the true explanation for the known prognostic effect of the LN harvest in colon cancer.

journal_name

Am J Clin Pathol

authors

Märkl B,Wieberneit J,Kretsinger H,Mayr P,Anthuber M,Arnholdt HM,Schenkirsch G

doi

10.1093/ajcp/aqw074

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

826-36

issue

6

eissn

0002-9173

issn

1943-7722

pii

aqw074

journal_volume

145

pub_type

杂志文章
  • Endometrial stromal sarcomas: immunoprofile with emphasis on HMB45 reactivity.

    abstract:OBJECTIVES:We describe the morphologic and immunohistochemical features of 17 endometrial stromal neoplasms, 16 sarcomas, and one stromal nodule. METHODS:We reviewed 35 cases interpreted as endometrial stromal neoplasms, but 17 high-grade endometrial stromal sarcomas (ESS) and one case of mixed endometrial sarcoma and...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPS88CMJRXZBWA

    authors: Albores-Saavedra J,Dorantes-Heredia R,Chablé-Montero F,Chanona-Vilchis J,Pérez-Montiel D,Lino-Silva LS,González-Romo MA,Ramírez-Jaramillo JM,Henson DE

    更新日期:2014-06-01 00:00:00

  • Papillary thyroid carcinoma with heterotopic ossification is a special subtype with extensive progression.

    abstract::An immunohistochemical study was conducted of 108 papillary carcinoma cases, including 48 cases with intratumoral heterotopic ossification (IHO). In 48 cases, papillary carcinoma with IHO was accompanied by nodular fibrosis. Cases of papillary carcinoma with IHO or nodular fibrosis showed higher incidences of lymph no...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPQZQN50HKIAHA

    authors: Takeda M,Mikami T,Numata Y,Okamoto M,Okayasu I

    更新日期:2013-05-01 00:00:00

  • The antimicrobial removal device. A microbiological and clinical evaluation.

    abstract::A parallel study of blood cultured conventionally and following processing in an Antimicrobial Removal Device (ARD) was conducted with patients suspected of being clinically bacteremic. Cultures yielded 205 isolates from 87 clinically bacteremic patients, of whom 28 were receiving antibiotics at the time their culture...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.2.173

    authors: Wright AJ,Thompson RL,McLimans CA,Wilson WR,Washington JA 2nd

    更新日期:1982-08-01 00:00:00

  • The significance of light chain-restricted bone marrow plasma cells after peripheral blood stem cell transplantation for multiple myeloma.

    abstract::While plasmacytosis is a common occurrence in early post-bone marrow transplantation biopsy specimens, the significance of plasma cells in such specimens from patients with multiple myeloma (MM) is unknown. We attempted to retrospectively determine, by morphologic assessment of plasma cell percentage, immunohistologic...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/107.6.643

    authors: Maia DM,Kell DL,Goates JJ,Warnke RA

    更新日期:1997-06-01 00:00:00

  • The evaluation of factor VIII binding activity of von Willebrand factor by means of an ELISA method: significance and practical implications.

    abstract::One of the functions of von Willebrand factor (vWF) is to serve as a carrier of clotting factor VIII (FVIII). Deficiency of this function results in the von Willebrand disease (vWD) variant type 2N, which resembles hemophilia A. We describe a new sandwich enzyme-linked immunosorbent assay (ELISA) to study the ability ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/109.3.347

    authors: Casonato A,Pontara E,Zerbinati P,Zucchetto A,Girolami A

    更新日期:1998-03-01 00:00:00

  • Results of multiparameter studies of T-cell lymphoid neoplasms.

    abstract::By application of combined structural and functional analyses, most lymphoid neoplasms may be categorized as of T- or B-cell origin. T lymphocyte neoplasms include types of acute and chronic lymphocytic leukemias, certain cutaneous and node-based lymphomas, and lymphomas of thymocytes (convoluted lymphocytic lymphomas...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Collins RD,Waldron JA,Glick AD

    更新日期:1979-10-01 00:00:00

  • Evaluation of HPV-16 and HPV-18 genotyping for the triage of women with high-risk HPV+ cytology-negative results.

    abstract::The ATHENA (Addressing THE Need for Advanced HPV Diagnostics) HPV study evaluated the clinical usefulness of the cobas HPV Test (Roche Molecular Systems, Pleasanton, CA) for high-risk human papillomavirus (HR-HPV) testing (14 HR types) and individual HPV-16/HPV-18 genotyping in women undergoing routine cervical cytolo...

    journal_title:American journal of clinical pathology

    pub_type: 临床试验,杂志文章

    doi:10.1309/AJCPTUS5EXAS6DKZ

    authors: Wright TC Jr,Stoler MH,Sharma A,Zhang G,Behrens C,Wright TL,ATHENA (Addressing THE Need for Advanced HPV Diagnostics) Study Group.

    更新日期:2011-10-01 00:00:00

  • Immunohistochemical expression of angiogenesis-related markers in oral squamous cell carcinomas with multiple metastatic lymph nodes.

    abstract::The aim of this study was to evaluate the histopathologic features and the expression of angiogenesis-related markers in primary tumors and metastatic lymph nodes of oral squamous cell carcinomas (SCCs) with multiple lymph node involvement in comparison with oral SCCs without nodal metastasis. The protein levels of th...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/JD3D-HGCD-GAUN-1R0J

    authors: Nikitakis NG,Rivera H,Lopes MA,Siavash H,Reynolds MA,Ord RA,Sauk JJ

    更新日期:2003-04-01 00:00:00

  • Differentiation of primary and secondary cutaneous B-cell lymphoma by Southern blot analysis.

    abstract::Malignant B-cell lymphomas represent a heterogenous group of lymphoreticular disorders that involve the skin in about 20% of reported cases. Skin involvement may be primary or secondary (ie, the result of hematogenous spread). Primary cutaneous B-cell lymphomas (PCBCLs) are thought to take a comparatively favorable co...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/106.6.749

    authors: Sepp N,Weyer K,Haun M,Zelger B,Thaler J,Faber V,Fritsch P,Grünewald K

    更新日期:1996-12-01 00:00:00

  • Prospects of cure in lymphocyte-predominant Hodgkin's disease.

    abstract::This report concerns a particular benign histologic variant of Hodgkin's disease, the lymphocyte-predominant category of the Rye classification. The group of 24 cases, all involving localized disease, was first reported in 1960, and is now reappraised, incorporating subsequent data. The interpretations of the original...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/67.6.507

    authors: Wright CJ

    更新日期:1977-06-01 00:00:00

  • Correlation of pathologic features with clinical outcome in pediatric adrenocortical neoplasia. A study of a Brazilian population. Brazilian Group for Treatment of Childhood Adrenocortical Tumors.

    abstract::Although the relationship between pathologic features and clinical outcome is well established in adult adrenocortical neoplasms, the prognostic value of these features in pediatric adrenocortical neoplasms (PACN) is unclear. In a series of PACNs from 54 Brazilian children, the authors retrospectively investigated the...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/101.5.625

    authors: Bugg MF,Ribeiro RC,Roberson PK,Lloyd RV,Sandrini R,Silva JB,Epelman S,Shapiro DN,Parham DM

    更新日期:1994-05-01 00:00:00

  • Indirect methods of assessing thyroid function. Protein-bound iodine and thyroxine by column chromatography, a 1976 CAP survey.

    abstract::An assessment of the infrequently performed protein-bound iodine determinations (PBI) and thyroxine (T4) determinations by column chromatography is presented after analysis of data contributed by participants in the 1976 College of American Pathologists Chemistry Survey Programs. The two technics yield comparable mean...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Thiessen MM,Batsakis JG,Neuhoff J,Thomas BP

    更新日期:1978-09-01 00:00:00

  • Immunohistochemical evaluation of estrogen and progesterone receptor content in 183 patients with endometrial carcinoma. Part II: Correlation between biochemical and immunohistochemical methods and survival.

    abstract::One hundred eighty-three patients with endometrial carcinoma had both immunohistochemical and biochemical analysis of estrogen receptor (ER) and progesterone receptor (PR) content of the tumor. Biochemical analysis was done on a homogenate of uterine curettings; immunohistochemical stainings were done on formalin-fixe...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/94.3.255

    authors: Chambers JT,Carcangiu ML,Voynick IM,Schwartz PE

    更新日期:1990-09-01 00:00:00

  • DNA typing of the human MN and Ss blood group antigens in amniotic fluid and following massive transfusion.

    abstract::Although red blood cell (RBC) antigen typing by agglutination is generally useful, several situations exist where this approach is difficult or impossible. For example, following a massive transfusion, a patient's residual RBCs are mixed with transfused normal donor RBCs. In this case, typing by hemagglutination prima...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/103.3.353

    authors: Eshleman JR,Shakin-Eshleman SH,Church A,Kant JA,Spitalnik SL

    更新日期:1995-03-01 00:00:00

  • Cellular and humoral immunity in viral hepatitis.

    abstract::Cellular and humoral immunity combine to determine the outcome following exposure to hepatitis virus and are implicated in the proposed pathogenetic mechanism for acute and chronic hepatitis. Although antibody to HBsAg is found in virtually all following recovery from hepatitis B, a cell-mediated response to HBsAg can...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:

    authors: Lee WM

    更新日期:1976-05-01 00:00:00

  • Soft agar culture of human transitional cell carcinoma colonies from urine.

    abstract::Soft-agar culture of transitional cell carcinoma colonies from urine, bladder irrigation fluid, and transurethral resection solid tumor specimens demonstrate generally better growth of tumor cell colonies from urine than from irrigation fluid. Growth of tumor colonies from urine was adequate to evaluate presence of tu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.5.690

    authors: Kirkels WJ,Pelgrim OE,Debruyne FM,Vooijs GP,Herman CJ

    更新日期:1982-11-01 00:00:00

  • Forty Postmortem Examinations in COVID-19 Patients.

    abstract:OBJECTIVES:Although diffuse alveolar damage, a subtype of acute lung injury (ALI), is the most common microscopic pattern in coronavirus disease 2019 (COVID-19), other pathologic patterns have been described. The aim of the study was to review autopsies from COVID-19 decedents to evaluate the spectrum of pathology and ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa156

    authors: De Michele S,Sun Y,Yilmaz MM,Katsyv I,Salvatore M,Dzierba AL,Marboe CC,Brodie D,Patel NM,Garcia CK,Saqi A

    更新日期:2020-11-04 00:00:00

  • CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms.

    abstract::We evaluated the immunohistochemical profile and specificity of CD138 reactivity in 238 specimens from hematopoietic and nonhematopoietic neoplasms. In 91 bone marrow biopsies, CD138 reactivity was observed for nonneoplastic plasma cells, neoplastic plasma cells in multiple myeloma cases (43/43), and the plasmacytic c...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/617D-WB5G-NFWX-HW4L

    authors: O'Connell FP,Pinkus JL,Pinkus GS

    更新日期:2004-02-01 00:00:00

  • The expression of HLA class I antigens in germ cell testicular cancer.

    abstract::The expression of HLA class I antigens in testicular germ cell tumors (TGCTs) was studied by the immunoperoxidase technique. In the normal testicle, the interstitial cells of Leydig as well as most of the germ cells were significantly stained. In typical seminoma, 75% of the tumor cells in stage I and 30% in stage II ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/93.2.202

    authors: Klein B,Klein T,Konichezky M,Nyska A,Livini E,Levine I,Zamir R,Kooperman O,Lurie H

    更新日期:1990-02-01 00:00:00

  • Common genomic aberrations in basaloid squamous cell carcinoma and carcinosarcoma of the esophagus detected by CGH and array CGH.

    abstract::Basaloid squamous cell carcinoma (BSCC) and carcinosarcoma of the esophagus are rare entities, making up fewer than 2% of esophageal malignancies. Comparative genomic hybridization (CGH) in 1 case of BSCC and 2 cases of carcinosarcoma and subsequent array CGH in 1 case each of BSCC and carcinosarcoma revealed common c...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPZ1O7UUUISPNR

    authors: Schaefer IM,Enders C,Polten A,Haller F,Frölich AM,Cameron S,Schüler P,Schweiger P,Gunawan B,Beham A,Füzesi L

    更新日期:2011-04-01 00:00:00

  • Infections caused by Actinomyces viscosus.

    abstract::Two cases of Actinomyces viscosus infection of the lungs were seen in nonimmunosuppressed patients. One patient had a peripheral actinomycotic lung mass resembling a tumor. Both patients responded to a long course of penicillin therapy. Reports of A. viscosus infections are rare, although the organism colonizes the mo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/75.1.113

    authors: Eng RH,Corrado ML,Cleri D,Cherubin C,Goldstein EJ

    更新日期:1981-01-01 00:00:00

  • Primary CD20+CD10+CD8+ T-cell lymphoma of the skin with IgH and TCR beta gene rearrangement.

    abstract::Most cutaneous T-cell lymphomas are derived from mature postthymic T cells of the CD4 subtype. When other less common profiles are encountered, a diagnostic challenge is posed. Accurate categorization is critical because of the specificity of therapeutic regimens, including biologics. A 65-year-old woman was seen in 2...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/HPYG-FLNX-KFBH-DQEV

    authors: Magro CM,Seilstad KH,Porcu P,Morrison CD

    更新日期:2006-07-01 00:00:00

  • Esterase activity in erythroleukemia.

    abstract::Specific esterase activity, a property generally ascribed to cells of granulocytic origin, was found in abnormal erythroid precursors obtained from the bone marrows of six patients with untreated erythroleukemia. These erythroblasts also showed nonspecific esterase activity. Neither specific nor nonspecific esterase a...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/67.4.368

    authors: Kass L

    更新日期:1977-04-01 00:00:00

  • Rhabdomyosarcomas of the uterus.

    abstract::The authors report the clinicopathologic findings in four cases of adult women with rhabdomyosarcomas that originated in the endometrium or cervix, or both. All tumors were pure sarcomas and not components of carcinosarcomas or malignant mixed mesodermal tumors. In two patients, the tumors were typical botryoid embryo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/70.2.217

    authors: Hart WR,Craig JR

    更新日期:1978-08-01 00:00:00

  • Prevalence and cellular reservoir of latent human herpesvirus 6 in tonsillar lymphoid tissue.

    abstract::There are few studies that examine prevalence, quantity, and cellular proclivity of latent human herpesvirus 6 (HHV-6) in healthy populations. We examined 69 tonsils with paired blood specimens from children without evidence of acute infection. By polymerase chain reaction (PCR), HHV-6 was detected at low levels in 10...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/Y2HH-B1CK-0F5L-U7B8

    authors: Roush KS,Domiati-Saad RK,Margraf LR,Krisher K,Scheuermann RH,Rogers BB,Dawson DB

    更新日期:2001-11-01 00:00:00

  • Community-acquired bacteremic Achromobacter xylosoxidans type IIIa pneumonia in a patient with idiopathic IgM deficiency.

    abstract::A man was hospitalized with bacteremic Achromobacter xylosoxidans type IIIa pneumonia. The authors are aware of no previously reported similar infections caused by this bacterium. A clinical cure was achieved with a combination of carbenicillin and kanamycin therapy. Microtiter susceptibility testing revealed that car...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/70.4.712

    authors: Dworzack DL,Murray CM,Hodges GR,Barnes WG

    更新日期:1978-10-01 00:00:00

  • Automated enumeration of immature granulocytes.

    abstract::The performance characteristics of the XE-2100 (Sysmex, Kobe, Japan) automated immature granulocyte (IG) count were studied. The automated IG count was compared with the manual morphology count and with a proposed reference flow cytometric count. The comparison data were analyzed by both least-squares and Passing-Babl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/TVGKD5TVB7W9HHC7

    authors: Fernandes B,Hamaguchi Y

    更新日期:2007-09-01 00:00:00

  • An approach to immunomicroscopy of renal disease with immunoperoxidase and periodic acid-Schiff counterstain (IMPAS stain).

    abstract::A series of 127 renal specimens reflecting a wide spectrum of renal pathology was evaluated with a direct immunoperoxidase technic in which frozen tissue was first reacted with anti-Ig(G,A,M) and anti-C3-peroxidase conjugates and subsequently counterstained with periodic acid-Schiff-hematoxylin (IMPAS). This technic p...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/73.2.240

    authors: Tubbs RR,Gephardt G,Valenzuela R,Deodhar S

    更新日期:1980-02-01 00:00:00

  • Antithrombin III and Factor VIII in patients with neoplasms.

    abstract::Possible increased activation of the coagulation pathway was measured in a group of patients with neoplastic diseases. In addition to standard tests, the thromboplastin generation test, thrombin generation test and immunologic and coagulant activities of both Factor VIII and antithrombin III were utilized in the evalu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/68.2.258

    authors: Losito R,Beaudry P,Valderrama JC,Cousineau L,Longpré B

    更新日期:1977-08-01 00:00:00

  • Humoral and cellular studies of eosinophils in reactive and myeloproliferative syndromes with marked eosinophilia.

    abstract::In five patients with eosinophilia and myeloproliferative disorders, the IgE levels were normal, and immune complexes were not detected. In contrast, in six patients with reactive eosinophilia accompanying immunologic diseases, the IgE levels were elevated in five, and immune complexes were elevated in two. Five of si...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.3.301

    authors: Crowley JP,Myers TJ

    更新日期:1983-03-01 00:00:00