Prekallikrein inhibition associated with the lupus anticoagulant: a mechanism of thrombosis.

abstract：:The authors investigated assays for free protein S (ProS) antigen, total ProS antigen, and ProS crossed immunoelectrophoresis (CIEP) in the diagnosis of type 1 inherited ProS deficiency. Accurate measurement of the hemostatically important free ProS required showing that, on each specimen, precipitation of the C4b-bin...

journal_title：American journal of clinical pathology

authors： Edson JR,Vogt JM,Huesman DA

更新日期：1990-08-01 00:00:00

abstract：:Venous thromboembolism (VTE) results from the interaction of the Virchow triad (venous stasis, endothelial injury, and hypercoagulability). Risk factors for increased hypercoagulability, or thrombophilia, include activated protein C resistance/factor V Leiden, the prothrombin G20210A mutation, deficiencies of the natu...

journal_title：American journal of clinical pathology

authors： Ballard RB,Marques MB,Education Committee of the Academy of Clinical Laboratory Physicians and Scientists.

更新日期：2012-04-01 00:00:00

abstract：:A case is presented of an anterior mediastinal mass arising in a 64-year-old woman that showed on histologic, immunopathologic, and ultra-structural examination features of a poorly differentiated (insular) thyroid carcinoma. The tumor in this patient most likely arose from ectopically displaced thyroid tissue on the ...

journal_title：American journal of clinical pathology

authors： Dominguez-Malagon H,Guerrero-Medrano J,Suster S

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVES:Long-term follow-up is important for determining performance characteristics of thyroid fine-needle aspiration (FNA). METHODS:Histologic or 3 or more years of clinical follow-up was used to calculate performance characteristics of thyroid FNA before and after implementation of The Bethesda System for Report...

journal_title：American journal of clinical pathology

authors： Sauter JL,Lehrke H,Zhang X,Al Badri OT,Rodriguez-Gutierrez R,Delivanis DA,Singh Ospina N,Donegan D,Hamidi O,Iñiguez-Ariza N,Sharma A,Kittah NEN,Tamhane SU,Hurtado Andrade MD,Kotwal A,Jenkins SM,Spears G,Rivera M,Dean

更新日期：2019-09-09 00:00:00

abstract：:Clinical data and histologic sections of the liver, including immunohistochemical studies for hepatitis B surface and core antigens, were reviewed in 42 autopsy cases of the acquired immune deficiency syndrome (AIDS). Hepatomegaly, elevation of serum transaminases, and mild elevation of alkaline phosphatase were commo...

journal_title：American journal of clinical pathology

authors： Glasgow BJ,Anders K,Layfield LJ,Steinsapir KD,Gitnick GL,Lewin KJ

更新日期：1985-05-01 00:00:00

abstract：:To establish the effect of a quality control failure on the performance of the LCx-GC nucleic-acid amplification assay for Neisseria gonorrhoeae (Abbott Laboratories, Abbott Park, IL) in the field, we conducted a retrospective analysis comparing the clinical and analytic performance of the recalled lots with those not...

journal_title：American journal of clinical pathology

authors： Skeate RC,Wahi MM,Hanson KL,Cartwright CP

更新日期：2005-06-01 00:00:00

abstract：:This report describes the selective staining of lysosomes in cells of neutrophilic granulocytic origin by the azo textile dye basic blue 93. Used as a single agent aqueous stain after fixation, the dye stained lysosomes black. Stained in this way, lysosomes were sharply delimited and easily visualized. Large numbers o...

journal_title：American journal of clinical pathology

authors： Kass L

更新日期：1988-02-01 00:00:00

abstract：:Poor core laboratory performance that causes delays in diagnosis and treatment is an impediment to optimal patient care, particularly in high-volume patient care areas such as the emergency department (ED). To evaluate the impact of laboratory performance on patient care outcomes, we obtained data from 11 hospitals re...

journal_title：American journal of clinical pathology

authors： Holland LL,Smith LL,Blick KE

更新日期：2005-11-01 00:00:00

abstract：:We evaluated a comprehensive deidentification engine at the University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, that uses a complex set of rules, dictionaries, pattern-matching algorithms, and the Unified Medical Language System to identify and replace identifying text in clinical reports while preserving ...

journal_title：American journal of clinical pathology

authors： Gupta D,Saul M,Gilbertson J

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVES:To identify, describe, and investigate the clinical, radiologic, and pathologic features of 8 cases of telangiectatic oncocytoma. METHODS:Fifty-three consecutive renal oncocytomas were reviewed for the telangiectatic pathologic features that were subsequently correlated with the demographic, clinical, and r...

journal_title：American journal of clinical pathology

authors： Xiao GQ,Ko HB,Unger P

更新日期：2013-07-01 00:00:00

abstract：:The Digene Hybrid Capture 2 (hc2) high-risk human papillomavirus (HPV) DNA test (Digene, Gaithersburg, MD) is widely used for triage of women with atypical squamous cells of undetermined significance. Results in a "retest zone" (weakly positive tests) are repeated up to 2 times according to the Digene-recommended algo...

journal_title：American journal of clinical pathology

authors： Muldrew KL,Beqaj SH,Han J,Lum SH,Clinard V,Schultenover SJ,Tang YW

更新日期：2007-01-01 00:00:00

abstract：:Thirty-five patients with dermatopathic lymphadenopathy, 12 with (9 patients and 3 follow-up) and 23 without associated mycosis fungoides, and 7 controls with 26 lymph nodes were studied by light microscopic examination and immunostaining for S-100 protein. Fourteen of these cases were examined ultrastructurally. The ...

journal_title：American journal of clinical pathology

authors： Herrera GA

更新日期：1987-02-01 00:00:00

abstract：:To investigate the effect of matrix-degrading enzymes on the malignant potential of oral squamous cell carcinoma, the expression of matrix metalloproteinase-2 (MMP-2/72-kD gelatinase/type IV collagenase) in 46 patients who had neck surgery for oral cancer was studied immunohistochemically. In 20 of 26 patients (76.9%)...

journal_title：American journal of clinical pathology

authors： Kusukawa J,Sasaguri Y,Shima I,Kameyama T,Morimatsu M

更新日期：1993-01-01 00:00:00

abstract：:The authors report two cases of vernix caseosa peritonitis, an infrequent complication of cesarean section with distinctive histopathologic findings. Both patients underwent exploratory laparotomy for unexplained abdominal pain after cesarean section. Histopathologic evaluation of surgically removed tissue revealed an...

journal_title：American journal of clinical pathology

authors： George E,Leyser S,Zimmer HL,Simonowitz DA,Agress RL,Nordin DD

更新日期：1995-06-01 00:00:00

abstract：:Immunohistochemical analysis, the most efficient way of assaying for HER-2/neu overexpression in patients with invasive breast cancer, is subject to variation in sensitivity and evaluation when used in multiple laboratories. Cell lines with differing but constant levels of HER-2/neu expression have been advocated as s...

journal_title：American journal of clinical pathology

authors： Rhodes A,Borthwick D,Sykes R,Al-Sam S,Paradiso A

更新日期：2004-07-01 00:00:00

abstract：:Abbreviated pretransfusion testing, although permitted by American Association of Blood Banks Standards for unimmunized patients, is not widely practiced. Concerns remain about optimal antibody screening methods, antibodies missed by deleting the antiglobulin crossmatch, and cost-effectiveness. The authors prospective...

journal_title：American journal of clinical pathology

authors： Cordle DG,Strauss RG,Snyder EL,Floss AM

更新日期：1990-10-01 00:00:00

abstract：:A patient with a polymicrobial bacteremia due to Nocardia asteroides and Escherichia coli is presented. Rapid overgrowth of all cultures with the E. coli necessitated the use of selective media containing antimicrobial agents to which the E. coli was sensitive. Only five previous cases of N. asteroides bacteremia have...

journal_title：American journal of clinical pathology

authors： Ruebush TK 2nd,Goodman JS

更新日期：1975-10-01 00:00:00

abstract：:One of the functions of von Willebrand factor (vWF) is to serve as a carrier of clotting factor VIII (FVIII). Deficiency of this function results in the von Willebrand disease (vWD) variant type 2N, which resembles hemophilia A. We describe a new sandwich enzyme-linked immunosorbent assay (ELISA) to study the ability ...

journal_title：American journal of clinical pathology

authors： Casonato A,Pontara E,Zerbinati P,Zucchetto A,Girolami A

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVES:The National Cancer Institute (NCI) National Clinical Trials Network performs phase II and III clinical trials, which increasingly rely on the submission of diagnostic formalin-fixed, paraffin-embedded tissue blocks for biomarker assessment. Simultaneously, advances in precision oncology require that clinica...

journal_title：American journal of clinical pathology

authors： Makhlouf H,Watson MA,Lankes HA,Weil C,Dickler M,Birrer M,Moskaluk C,Ramirez NC,Okby N,Alonsozana E,Barnes M,Goldman EB,Enos R,Lubensky I

更新日期：2020-01-02 00:00:00

abstract：:Demonstration of prostate-specific acid phosphatase by immunologic methods in tissue sections or in plasma necessitates a monospecific antiserum. This is produced by immunizing rabbits with pure prostate-specific acid phosphatase antigen, prepared from seminal fluid. The ejaculate is centrifuged, dialyzed against a ci...

journal_title：American journal of clinical pathology

authors： de Vries GP,Slob AW,Jöbsis AC,Meijer AE,Sanders GT

更新日期：1979-12-01 00:00:00

abstract：:Plasma biomarker analysis requires intact unbiased starting material. We analyzed the effects on plasma protein profiles of protease inhibitor cocktails and preprocessing storage. Plasma from 12 healthy subjects collected with and without protease inhibitors was prepared immediately and after 2 hours of room temperatu...

journal_title：American journal of clinical pathology

authors： Ayache S,Panelli M,Marincola FM,Stroncek DF

更新日期：2006-08-01 00:00:00

abstract：:The expression of the cell-cycle-associated Ki-67 antigen by MIB-1 monoclonal antibody was retrospectively assessed in 35 surgically resected neuroendocrine tumor specimens of the pancreas embedded in paraffin. The MIB-1 proliferation index was correlated with the classification of the neuroendocrine tumors of the pan...

journal_title：American journal of clinical pathology

authors： Gentil Perret A,Mosnier JF,Buono JP,Berthelot P,Chipponi J,Balique JG,Cuilleret J,Dechelotte P,Boucheron S

更新日期：1998-03-01 00:00:00

abstract：:Cytogenetic studies of bone marrow were performed in 230 consecutive cases of patients with chronic granulocytic leukemia (CGL) admitted to the National Cancer Institute since 1961. Twenty patients lacked the Philadelphia (Ph1) chromosome. All were previously untreated. When compared with Ph1-positive patients, CGL pa...

journal_title：American journal of clinical pathology

authors： Canellos GP,Whang-Peng J,DeVita VT

更新日期：1976-04-01 00:00:00

abstract：:Remarkable improvements have been made in blood safety since the onset of the HIV epidemic. However, the current paradigm does not prevent all transfusion-transmitted infections and is reactive to new agents, thus accepting that some patients may be harmed before preventive measures are introduced. Several methods are...

journal_title：American journal of clinical pathology

authors： McCullough J

更新日期：2007-12-01 00:00:00

abstract：:An evaluation of the validity in infants of standard computations for the correction of white cell counts in blood-contaminated cerebrospinal fluid (traumatic lumbar puncture) was undertaken. In 39 infants with significant blood contamination (greater than 10(4) red blood cells/microL) and no evidence of bacterial men...

journal_title：American journal of clinical pathology

authors： Novak RW

更新日期：1984-07-01 00:00:00

abstract：:We undertook a retrospective analysis of colonic spirochetosis in 14 cases: females, 3; males, 11; children, 4; adults, 10. Two men had HIV infections. All children and both HIV-infected men had abdominal complaints, diarrhea, or both. Most other adults underwent colonoscopy for polyp screening (n = 4) or follow-up of...

journal_title：American journal of clinical pathology

authors： Koteish A,Kannangai R,Abraham SC,Torbenson M

更新日期：2003-12-01 00:00:00

abstract：:Primary angiosarcomas of the uterus are exceedingly rare. The authors report a unique case of this entity arising in connection with uterine leiomyomas. The malignant tumor cells showed focally epithelioid features and were immunoreactive for keratin. Electron microscopy and immunohistochemistry confirmed their endoth...

journal_title：American journal of clinical pathology

authors： Tallini G,Price FV,Carcangiu ML

更新日期：1993-11-01 00:00:00

abstract：:This study examines the relationship between age and mitogen-induced lymphocyte blastogenesis. Lymphocytes were stimulated with PHA; Concanavalin A (Con A), and PWM in 156 normal, healthy subjects ranging in age from birth to 75 years. The findings indicate a gradual but significant decrease in PHA- and Con A-induced ...

journal_title：American journal of clinical pathology

authors： Hicks MJ,Jones JF,Thies AC,Weigle KA,Minnich LL

更新日期：1983-08-01 00:00:00

abstract：:Peripheral blood samples of 23 patients who had hairy cell leukemia were examined for leukocyte alkaline phosphatase scores. Leukocyte alkaline phosphatase levels were elevated in seventeen patients (74%), were normal in six (26%), and were not decreased in any patient. The mean leukocyte alkaline phosphatase score wa...

journal_title：American journal of clinical pathology

authors： Aiba M,Raffa PP,Katayama I

更新日期：1980-09-01 00:00:00

abstract：:This review summarizes our experience using blinded review as a method to measure quality in surgical pathology. It details the specifics about how the review is performed, the weaknesses in the method, and then summarizes our results so far. These results suggest that error rates correlate with the individual patholo...

journal_title：American journal of clinical pathology

authors： Renshaw AA,Gould EW

更新日期：2007-01-01 00:00:00