Primary CD20+CD10+CD8+ T-cell lymphoma of the skin with IgH and TCR beta gene rearrangement.


:Most cutaneous T-cell lymphomas are derived from mature postthymic T cells of the CD4 subtype. When other less common profiles are encountered, a diagnostic challenge is posed. Accurate categorization is critical because of the specificity of therapeutic regimens, including biologics. A 65-year-old woman was seen in 2001 because of a thigh mass manifesting an unusual phenotype eventually categorized as a mature postthymic CD8+ T-cell lymphoma with CD10 and weak CD20 expression. Molecular studies revealed T-cell receptor and heavy chain immunoglobulin rearrangement. Her cutaneous disease progressed despite several cycles of chemotherapy and radiation therapy. However, a therapeutic trial with denileukin diftitox resulted in a striking response. The importance of this case lies in the novel phenotype and dual T- and B-cell rearrangements. Rather than representing an aberrant phenotype, this tumor may represent the malignant counterpart of a benign population of weakly CD20+ T cells of the CD8 subset.


Am J Clin Pathol


Magro CM,Seilstad KH,Porcu P,Morrison CD




Has Abstract


2006-07-01 00:00:00














  • Psammoma bodies in malignant carcinoid tumor metastases.

    abstract::A clinically and histopathologically well-documented case of malignant carcinoid tumor (with carcinoid syndrome) is described. The presence of numerous psammoma bodies in metastatic carcinoid tumor deposits, confirmed by histochemical and ultrastructural analyses, represents a heretofore unreported finding. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Caya JG,Tieu TM,Wollenberg NJ,Soergel K,Anderson T

    更新日期:1984-03-01 00:00:00

  • Evaluation of the DCL Syphilis-G enzyme immunoassay test kit for the serologic diagnosis of syphilis.

    abstract::Sera have been submitted to the authors' laboratory for syphilis testing at a dramatically increased rate since the start of the human immunodeficiency virus type 1 epidemic. Thus they were interested in evaluating a new enzyme immunoassay, the DCL Syphilis-G test kit (DCL-G, Diagnostic Chemicals Ltd., Oxford, CT) for...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Nayar R,Campos JM

    更新日期:1993-03-01 00:00:00

  • Immunohistochemical analysis of oral lichen-planus-like eruption in graft-versus-host disease after allogeneic bone marrow transplantation.

    abstract::Immunohistochemical analysis of oral lichen-planus-like eruption (LPLE) in graft-versus-host disease (GVHD) using monoclonal antibodies (MoAbs) was performed on five patients after allogeneic bone marrow transplantation (BMT) for leukemia. In the mucosal lesions of LPLE in GVHD, the major population of infiltrated lym...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Fujii H,Ohashi M,Nagura H

    更新日期:1988-02-01 00:00:00

  • Fluorescent cytochemical detection of estrogen and progesterone receptors in breast fine-needle aspirates.

    abstract::Estrogen and progesterone receptors were studied in fine-needle aspiration biopsy specimens of 56 patients with primary, recurrent, or metastatic breast carcinoma. The ligands, 17 B-estradiol-6-carboxymethyloxine-bovine serum albumin fluorescein isothiocyanate (FITC-BSA estradiol) and hydroxyprogesterone hemisuccinate...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Masood S

    更新日期:1991-01-01 00:00:00

  • Management training for pathology residents. I. Results of a national survey.

    abstract::The professional activities of anatomic and clinical pathologists involve, to a large extent, management issues. To evaluate the management training received by pathology residents, the authors surveyed pathology residency training programs in the United States. Responses were collected from 138 of 187 programs (73.8%...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Brugnara C,Fenton T,Winkelman JW

    更新日期:1994-05-01 00:00:00

  • A civilian case of fatal meningococcemia due to Neisseria meningitidis, group Y.

    abstract::The present report is that of a civilian episode of fatal, fulminant group Y meningococcemia in a previously healthy adolescent, who denied prior vaccination against group C meningococcus. The patient suffered abrupt onset of purpura, hypotension and cardiopulmonary arrest. A detailed clinical and pathologic report is...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Bernad PG,Snyder DA,Levey M

    更新日期:1977-08-01 00:00:00

  • Focus floating microscopy: "gold standard" for cutaneous borreliosis?

    abstract::Borrelia burgdorferi is difficult to detect in routine biopsy material from patients with skin lesions of borreliosis. In this study, a new immunohistochemical method, focus floating microscopy (FFM), was developed to detect B burgdorferi in tissue sections and was compared with polymerase chain reaction (PCR). By usi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Eisendle K,Grabner T,Zelger B

    更新日期:2007-02-01 00:00:00

  • Can We Identify Nephrogenic Adenoma in Urine Cytology Specimens? A Study Evaluating Previously Described Cytomorphologic Features in Correlation With PAX8 Immunohistochemical Staining Results.

    abstract:OBJECTIVES:The aim of this study is to determine if the diagnosis of nephrogenic adenoma (NA) can be made on cytologic criteria alone and if pair box gene transcription factor 8 (PAX8) is useful in the diagnosis of NA in daily cytology practice. METHODS:Cytologic features of NA previously described in a literature wer...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: McCroskey Z,Pambuccian SE,Wojcik EM,Barkan GA

    更新日期:2016-03-01 00:00:00

  • Cardiac troponin T is elevated in asymptomatic patients with chronic renal failure.

    abstract::Patients with chronic renal failure (CRF) are at increased risk for myocardial events that are difficult to evaluate due to atypical symptoms and chronically elevated protein markers of cardiac damage. This study evaluated cardiac troponin T (cTnT), a sensitive marker of cardiac injury, in patients with CRF without my...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Frankel WL,Herold DA,Ziegler TW,Fitzgerald RL

    更新日期:1996-07-01 00:00:00

  • Risk-benefit analysis of sampling methods for fine-needle aspiration cytology: a mathematical modeling approach.

    abstract::The effectiveness of fine-needle aspiration (FNA) increases with the number of needle passes, but needle passes are also associated with increased risk of adverse events. The trade-off between needle passes and adequacy has not been well characterized. Clinical studies are limited because of their inherent variability...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Schmidt RL,Kordy MA,Howard K,Layfield LJ,Hall BJ,Adler DG

    更新日期:2013-03-01 00:00:00

  • MDM2 copy numbers in well-differentiated and dedifferentiated liposarcoma: characterizing progression to high-grade tumors.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Ware PL,Snow AN,Gvalani M,Pettenati MJ,Qasem SA

    更新日期:2014-03-01 00:00:00

  • The incorporation of red blood cell index mean data into quality control programs.

    abstract::Patient red blood cell (RBC) index means, when used in quality control, form an independent standard that is as accurate and precise as preserved blood controls. If such patient data are routinely incorporated in intralaboratory and interlaboratory quality control programs, a substantial improvement in the present sta...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Levy WC,Bull BS,Koepke JA

    更新日期:1986-08-01 00:00:00

  • Hepatic oncocytes. Incidence, staining characteristics, and ultrastructural features.

    abstract::Hepatocytes with orcein-positive ground-glass cytoplasm have been shown to contain abundant hepatitis B surface antigen in the cisternae of excess smooth endoplasmic reticulum. Hepatocytes with similar cytoplasmic changes that did not react with orcein were observed in 26.5% of 49 cases of cirrhosis. These cells exhib...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Gerber MA,Thung SN

    更新日期:1981-04-01 00:00:00

  • Immunoreactivity of paraffin-embedded normal tissues and mesenchymal tumors for smooth muscle myosin.

    abstract::Immunohistochemical study of smooth muscle myosin, a protein distinct from skeletal, cardiac, or nonmyogenous myosins in paraffin-embedded normal tissues and benign and malignant mesenchymal tumors revealed its strong expression in normal smooth muscle, capillary endothelium, and pericytes. All benign smooth muscle tu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Donner L,de Lanerolle P,Costa J

    更新日期:1983-11-01 00:00:00

  • Hematologic and iron-related measurements in rheumatoid arthritis.

    abstract::The hematologic status of 265 patients with rheumatoid arthritis was assessed. In the group as a whole, a mild depression in the hemoglobin concentration and mean cell volume (MCV) was associated with an increase in the red blood cell distribution width (RDW), erythrocyte sedimentation rate (ESR), and platelet count. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Baynes RD,Bothwell TH,Bezwoda WR,Gear AJ,Atkinson P

    更新日期:1987-02-01 00:00:00

  • Native-valve endocarditis caused by Staphylococcus epidermidis. A histologically confirmed case.

    abstract::Staphylococcus epidermidis is among the most common organisms isolated from blood cultures. Conversely, it is rarely a well-documented cause of natural-valve endocarditis. However, several authors have reported series of patients with the clinical picture of endocarditis and S. epidermidis bacteremia. Most of these ca...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Littenberg B,Cooper B,Levitz R

    更新日期:1987-03-01 00:00:00

  • An Audit of Repeat Testing at an Academic Medical Center: Consistency of Order Patterns With Recommendations and Potential Cost Savings.

    abstract:Objectives:To evaluate the prevalence of potentially unnecessary repeat testing (PURT) and the associated economic burden for an inpatient population at a large academic medical facility. Methods:We evaluated all inpatient test orders during 2016 for PURT by comparing the intertest times to published recommendations. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Hueth KD,Jackson BR,Schmidt RL

    更新日期:2018-05-31 00:00:00

  • Development of North American consensus guidelines for medical laboratories that perform and interpret platelet function testing using light transmission aggregometry.

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    journal_title:American journal of clinical pathology

    pub_type: 共识发展会议,杂志文章,实务指引


    authors: Hayward CP,Moffat KA,Raby A,Israels S,Plumhoff E,Flynn G,Zehnder JL

    更新日期:2010-12-01 00:00:00

  • The College of American Pathologists comprehensive blood bank survey program, 1973.

    abstract::The 1973 Comprehensive Blood Bank Survey Program of the College of American Pathologists was administered to 2,200 laboratories and blood banks throughout the United States. The results showed a considerable increase in the accuracy of the testing and in the performance of reagents. Accuracy of ABO testing was 99.3%; ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Myhre BA,Koepke JA

    更新日期:1975-06-01 00:00:00

  • Histopathologic and molecular profile of human cytomegalovirus infections in patients with heart transplants.

    abstract::From November 1985 to December 1990, 2,552 endomyocardial biopsy specimens from 209 heart transplant patients were studied. Forty-four (21%) patients developed 45 episodes of major human cytomegalovirus infection (HCMV). Human cytomegalovirus infection was primary in 13 of 44 patients. Thirty-one patients developed ep...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Arbustini E,Grasso M,Diegoli M,Percivalle E,Grossi P,Bramerio M,Campana C,Goggi C,Gavazzi A,Vigano M

    更新日期:1992-08-01 00:00:00

  • Immunohistochemical characterization of renal amyloidosis.

    abstract::Forty-five renal biopsies with amyloidosis were studied by light microscopy with Congo red staining and action of potassium permanganate and by immunofluorescence with antihuman tissue A component antiserum antilight and heavy chains of immunoglobulins antisera. The patients were classified on the basis of concordance...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Noel LH,Droz D,Ganeval D

    更新日期:1987-06-01 00:00:00

  • Usefulness of a monoclonal ERG/FLI1 antibody for immunohistochemical discrimination of Ewing family tumors.

    abstract::Ewing family tumors (EFTs) and prostate carcinomas are characterized by rearrangement of ETS genes, most commonly FLI1 (EFTs) and ERG (prostate carcinomas). Previously, we characterized an antibody against ERG (EPR3864) for detecting ERG-rearranged prostate carcinoma. Because EPR3864 also cross-reacts with FLI1, we ev...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Tomlins SA,Palanisamy N,Brenner JC,Stall JN,Siddiqui J,Thomas DG,Lucas DR,Chinnaiyan AM,Kunju LP

    更新日期:2013-06-01 00:00:00

  • Are autopsies obsolete?

    abstract::To determine the current frequency of discovering important diagnoses at autopsy, the diagnoses made in all complete or "no head" autopsies during 1994 at a major tertiary care transplantation referral center were retrospectively compared with the diagnoses made antemortem. Of 176 autopsies, 79 (44.9%) revealed 1 or m...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Nichols L,Aronica P,Babe C

    更新日期:1998-08-01 00:00:00

  • Theory and applications of the polymerase chain reaction.

    abstract::The polymerase chain reaction (PCR) is a newly developed molecular biology technique that can significantly amplify DNA or RNA. The process consists of repetitive cycles of specific DNA synthesis, defined by short stretches of preselected DNA. With each cycle, there is a doubling of the final, desired DNA product such...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审


    authors: Remick DG,Kunkel SL,Holbrook EA,Hanson CA

    更新日期:1990-04-01 00:00:00

  • Decreased T-lymphocytes in patients with mammary cancer.

    abstract::The levels of thymus-derived lymphocytes (T-cells) in samples of peripheral blood from 47 patients with carcinoma of the breast, 36 patients with benign mammary lesions, and 33 matched normal controls were determined. Results were analyzed with three statistical tests. It was found that the mean percentages of T-lymph...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Keller SE,Ioachim HL,Pearse T,Siletti DM

    更新日期:1976-04-01 00:00:00

  • The bone marrow in disseminated Mycobacterium avium-intracellulare infection.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Farhi DC,Mason UG 3rd,Horsburgh CR Jr

    更新日期:1985-04-01 00:00:00

  • High-density lipoprotein cholesterol. Significant bias between methods.

    abstract::Cholesterol content of the high-density lipoproteins has become of interest in evaluating the risk of development of coronary heart disease. There is an inverse relationship between high-density lipoprotein cholesterol and risk. The authors found a significant bias (11.1 mg/dl; 0.289 mmol/l) in a comparison of a rapid...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Gerson B,Dean L,Copeland BE

    更新日期:1979-05-01 00:00:00

  • Platelet function, ultrastructure, and survival in the May-Hegglin anomaly.

    abstract::The May-Hegglin anomaly is one of the rare forms of heriditary thrombocytopenia. Since fewer than 100 cases of May-Hegglin anomaly have been described to date, major controversies regarding the adequacy of hemostasis in vivo and abnormalities of platelet function in vitro continue to prevail. This report describes the...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Hamilton RW,Shaikh BS,Ottie JN,Storch AE,Saleem A,White JG

    更新日期:1980-11-01 00:00:00

  • Frequency, Clinicopathologic Characteristics, and Follow-up of HER2-Positive Nonpleomorphic Invasive Lobular Carcinoma of the Breast.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Zhang H,Moisini I,Ajabnoor RM,Turner BM,D'aguiar M,Cai X,Gao S,Yang Q,Wang X,Schiffhauer L,Hicks DG

    更新日期:2020-04-15 00:00:00

  • Intrinsic factor, free of R proteins, can be prepared from mouse stomach and used in a ligand assay specific for "true" cobalamin.

    abstract::A ligand assay specific for cobalamin that uses mouse stomach as the source of intrinsic factor has been developed. When mouse stomach extract incubated with radiocobalamin is fractionated by gel chromatography, the radioactive complex elutes as a single peak with apparent molecular weight of 54,900. Formation of the ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Reynoso G,Tuggey R,Hansen H,Fontelo PA,Konopka S,Miller JT

    更新日期:1981-06-01 00:00:00