Abstract:
:Most cutaneous T-cell lymphomas are derived from mature postthymic T cells of the CD4 subtype. When other less common profiles are encountered, a diagnostic challenge is posed. Accurate categorization is critical because of the specificity of therapeutic regimens, including biologics. A 65-year-old woman was seen in 2001 because of a thigh mass manifesting an unusual phenotype eventually categorized as a mature postthymic CD8+ T-cell lymphoma with CD10 and weak CD20 expression. Molecular studies revealed T-cell receptor and heavy chain immunoglobulin rearrangement. Her cutaneous disease progressed despite several cycles of chemotherapy and radiation therapy. However, a therapeutic trial with denileukin diftitox resulted in a striking response. The importance of this case lies in the novel phenotype and dual T- and B-cell rearrangements. Rather than representing an aberrant phenotype, this tumor may represent the malignant counterpart of a benign population of weakly CD20+ T cells of the CD8 subset.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Magro CM,Seilstad KH,Porcu P,Morrison CDdoi
10.1309/HPYG-FLNX-KFBH-DQEVsubject
Has Abstractpub_date
2006-07-01 00:00:00pages
14-22issue
1eissn
0002-9173issn
1943-7722pii
HPYGFLNXKFBHDQEVjournal_volume
126pub_type
杂志文章abstract:OBJECTIVES:Mantle cell lymphoma (MCL) may present de novo or undergo progression to a clinically aggressive variant, known as a blastoid or pleomorphic variant. We report an unusual case of classic MCL in a 78-year-old man with a typical immunophenotype, including CD5 positivity, who subsequently relapsed with CD5-nega...
journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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更新日期:1990-03-01 00:00:00
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abstract::Over a four-month period, methanol was found in the blood of 18 patients among 687 sequential emergency room admissions screened for alcohols by gas chromatography. In the patients with positive results, blood ethanol ranged from 6 to 570 mg/dL (1.3-123.7 mmol/L), blood methanol from 2.3 to 4.0 mg/dL (0.72-1.25 mmol/L...
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更新日期:1978-12-01 00:00:00
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更新日期:1975-12-01 00:00:00
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更新日期:1981-03-01 00:00:00
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更新日期:1977-12-01 00:00:00
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更新日期:1994-02-01 00:00:00
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更新日期:2018-02-17 00:00:00
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更新日期:2005-01-01 00:00:00
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