Abstract:
:Vascular endothelial growth factor (VEGF) is one of the most potent mitogenic, highly specific tumor angiogenic factors, which acts via binding to 2 specific tyrosine kinase receptors. There are few studies analyzing VEGF receptor expression in prostate cancer cells, and results are contradictory. In an immunohistochemical study, we analyzed VEGF and VEGF receptor fetal liver kinase (Flk)-1 expression in benign glands, high-grade prostatic intraepithelial neoplasia (HGPIN), and prostatic carcinomas of different Gleason scores, obtained from 21 radical prostatectomy specimens. In all benign glands, VEGF and Flk-1 expression was confined almost exclusively to the basal cell layer (proliferative cell compartment). In HGPIN, labeling was no longer confined to the basal cell layer, but also was seen in all neoplastic secretory cells. All carcinomas stained positive for both markers. There was a trend for increasing labeling intensity with increasing cellular dedifferentiation. We concluded that tumor growth stimulated by the VEGF-Flk-1 system is promoted not only by neoangiogenesis, but also by tumor cell autostimulation. The VEGF-Flk-1 system may have an important role in the process of malignant transformation and tumor progression.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Köllermann J,Helpap Bdoi
10.1309/1LBM-6X32-JH6W-ENUDsubject
Has Abstractpub_date
2001-07-01 00:00:00pages
115-21issue
1eissn
0002-9173issn
1943-7722journal_volume
116pub_type
杂志文章abstract::A 73-year-old man with myelodysplastic syndrome developed during the course of his illness auto-immune hemolytic anemia. The association between auto-immune hemolysis and myeloproliferative disease is extremely rare. An even more unique finding is the nature of the antibody which demonstrated single specificity agains...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/77.3.356
更新日期:1982-03-01 00:00:00
abstract::Although Stat tests are one of the most important features of clinical laboratory performance, the indexed literature is devoid of significant discussion of the subject. The authors, undertook a study by querying hospital laboratories about their current practices and received 38 useable answers dealing with the types...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/69.5.520
更新日期:1978-05-01 00:00:00
abstract::Our purpose was to evaluate the clinical, histologic, and histochemical staining characteristics of intestinal metaplasia (IM) at an endoscopically normal-appearing esophagogastric junction (IM-EGJ) compared with IM in a columnar-lined esophagus (IM-CLE). A prospective study included 253 patients referred for elective...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/N15U-FN5R-3M5D-PE0U
更新日期:2002-01-01 00:00:00
abstract::Plasma samples from patients with severe classic hemophilia, suspected of having mild inhibitors not detected in the standard Bethesda inhibitor test, were examined in modified Bethesda tests and in a screening test based on the activated partial thromboplastin time (APTT). The APTT test was more sensitive to mild inh...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/77.6.749
更新日期:1982-06-01 00:00:00
abstract::A number of reports have highlighted discrepancies between the DuPont aca and fibrometer-based methods for quantitating plasma fibrinogen levels. Although many authors have suggested that the presence of fibrin(ogen) degradation products are in some way responsible for the discrepancies, no direct test of this hypothe...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/88.4.490
更新日期:1987-10-01 00:00:00
abstract:Objectives:To curtail inappropriate plasma transfusions, we instituted clinical decision support as an alert upon order entry if the patient's recent international normalized ratio (INR) was 1.7 or less. Methods:The alert was suppressed for massive transfusion and within operative or apheresis settings. The plasma ord...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/aqx061
更新日期:2017-08-01 00:00:00
abstract::A 76-year-old white man previous diagnosed as having Waldenstrom's macroglobulinemia continued with persistent fevers and sweats for two and a half years. Recently, repeated automated differentials during 11 days of hospitalization failed to note any intracellular inclusions in the RBCs. Blood sent to the Microbiology...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/83.4.520
更新日期:1985-04-01 00:00:00
abstract::We studied the presence of surfactant protein A (Sp-A) immunoreactivity and messenger RNA in 62 normal and abnormal breast samples. Sections were immunostained with polyclonal anti-Sp-A antibody. The association between Sp-A immunoreactivity and histologic grade of 32 invasive ductal carcinomas was assessed by 3 patho...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/DU7F-XYP8-1DF6-WM9E
更新日期:2001-11-01 00:00:00
abstract::Forty-three laboratories participated in an interlaboratory testing program offered by the College of American Pathologists for the radioimmunoassay (RIA) of carcinoembryonic antigen (CEA). Thirty correctly reported a sample with 1.9 ng of endogenous CEA per ml as less than 2.5 ng. For samples with added exogenous CEA...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract::Most cutaneous T-cell lymphomas are derived from mature postthymic T cells of the CD4 subtype. When other less common profiles are encountered, a diagnostic challenge is posed. Accurate categorization is critical because of the specificity of therapeutic regimens, including biologics. A 65-year-old woman was seen in 2...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/HPYG-FLNX-KFBH-DQEV
更新日期:2006-07-01 00:00:00
abstract::Twenty-five cases of tubal or tubo-endometrioid metaplasia that occurred in patients from 21 to 51 years of age (mean 39 years) are described. The majority of the cases were seen in consultation. They were referred because of diagnostic problems resulting from features that have received little emphasis. The metaplasi...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/103.5.618
更新日期:1995-05-01 00:00:00
abstract:Objectives:To evaluate the prognostic values of microRNAs (miRNAs) in glioblastoma, and to see if there is an association between miRNAs and MGMT promoter methylation status. Methods:We collected paraffin blocks from resection specimens from 114 glioblastoma patients who had received temozolomide treatment and radioth...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/aqy008
更新日期:2018-03-29 00:00:00
abstract::DNA sequencing was used to confirm Chlamydia trachomatis and Neisseria gonorrhoeae nucleic acids in endocervical swab samples. DNA in residues of the samples with positive results by 2 commercial kits was subjected to nested polymerase chain reaction (PCR) amplification. The nested PCR amplicons were used as templates...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/Y2202RVCGRWW1RWB
更新日期:2008-06-01 00:00:00
abstract::Infusible platelet membranes (IPMs) prepared from fresh or outdated human platelets have been shown to correct prolonged bleeding times in thrombocytopenic rabbits. In previous trials, IPMs did not seem to be immunogenic and lacked dose-limiting toxicity. The present study was undertaken to explore whether the platele...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/CCDV-3BEP-XXKP-BKDM
更新日期:2001-01-01 00:00:00
abstract::This study aimed to ascertain pathologic findings of surgical follow-up excision (FUE) on patients who had radiologic finding of calcifications and lobular neoplasia (LN) on core biopsy. Breast core biopsy specimens from 2006-2011 with a diagnosis of pure classic-type LN (lobular carcinoma in situ [LCIS] and atypical ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCPYG48TUTFIBMR
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVES:GATA3 is a transcription factor regulating luminal cell differentiation in the mammary glands and has been implicated in the luminal types of breast carcinoma. The prognostic significance of GATA3 in breast cancer remains controversial. METHODS:In this study, we assessed the prognostic value of the molecule...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCP5MMR1FJVVTPK
更新日期:2015-11-01 00:00:00
abstract::In this study, I have estimated the percentage of tumor by visual estimate in 447 prostatectomy specimens from American Veterans Affairs patients and related this measurement to overall survival. Although percentage of tumor was significantly related to the serum prostate-specific antigen level, tumor stage, and Gleas...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCPX5MAMNMFE6FQ
更新日期:2009-01-01 00:00:00
abstract::A series of 138 patients seen consecutively in an adult allergy clinic were studied to determine serum alpha1-antitrypsin (alpha1-AT) levels and protease inhibitor (Pi) phenotypes. These were compared with a control group of 700 healthy young adult blood donors. Both total serum trypsin inhibitory capacity (STIC) and ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/64.3.297
更新日期:1975-09-01 00:00:00
abstract:OBJECTIVES:To assess physicians' and nurses' satisfaction with the service provided by the laboratory at Gondar University Hospital. METHODS:We conducted a cross-sectional study involving 196 nurses and physicians. RESULTS:Overall level of satisfaction was 51.1% for nurses and 51.5% for physicians. Lack of consistenc...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCPU1PLVOIN5JQI
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVES:Assess support for the effectiveness of two separate practices, restrictive transfusion strategy and computerized physician order entry/clinical decision support (CPOE/CDS) tools, in decreasing RBC transfusions in adult surgical and nonsurgical patients. METHODS:Following the Centers for Disease Control and...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/aqz070
更新日期:2019-10-07 00:00:00
abstract::A 65-year-old man with lower back pain was found to have multiple myeloma. Unique findings in the marrow aspirate smears of this patient were tadpolelike plasma cells and cellular rosettes simulating those seen in neuroblastoma. This case documents yet another facet of the broad morphologic spectrum of neoplastic plas...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/98.6.630
更新日期:1992-12-01 00:00:00
abstract::The development of a consistent strategy for the analysis of oncogene expression at the cellular level is essential for understanding the roles of these genes in the development and progression of human neoplasia. Detection of the neu oncogene products in breast carcinoma was selected as a model for analysis of oncoge...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/94.2.125
更新日期:1990-08-01 00:00:00
abstract::We analyzed the diagnostic role of claudins in effusion cytology in 325 effusions, including 218 ovarian, 49 breast, 15 cervical or endometrial, 10 gastrointestinal, and 8 lung adenocarcinomas and 25 malignant mesotheliomas (MMs). Specimens were analyzed for claudin-1 and claudin-3 expression using immunohistochemical...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/V025QRN3R9CJGNPX
更新日期:2007-06-01 00:00:00
abstract::Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors characterized by mutations of KIT or PDGFRA. The objectives of this study were to evaluate BRAF mutations in GISTs and then to correlate BRAF mutational status in the tumor with clinical parameters, with B-raf expression, and with activation of some cellul...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCPPCKGA2QGBJ1R
更新日期:2010-01-01 00:00:00
abstract::Breast cancer in men is a rare condition affecting only 1,000 men each year in the United States. Hormonal, genetic, and perhaps environmental factors appear to be important in development of the disease. Clinically, breast cancer in men resembles that seen in woman. Histologically the diseases are indistinguishable, ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:
更新日期:1994-10-01 00:00:00
abstract:OBJECTIVES:Solid tumor metastases to the pancreas are rare, and only limited literature on the topic is available. In this retrospective study, we reviewed 107 cases of solid tumor metastases to the pancreas diagnosed by fine-needle aspiration (FNA) from 2005 to 2019. METHODS:Information including the patients' clinic...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/aqaa090
更新日期:2020-10-13 00:00:00
abstract:OBJECTIVES:Myeloid and lymphoid neoplasms with abnormalities of fibroblast growth factor receptor 1 gene (FGFR1) are a rare and aggressive disease group that harbors translocations of FGFR1 with at least 14 recognized partner genes. We report a case of a patient with a novel t(17;21)(p13;q22) with RUNX1 rearrangement a...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1309/AJCPUD6W1JLQQMNA
更新日期:2015-05-01 00:00:00
abstract::Tissue specimens from a series of 46 hepatic tumors occurring in young female oral contraceptive users were tested for alpha1-antitrypsin deposition, utilizing immunocytochemical and histochemical methods. In two instances serum alpha1-antitrypsin phenotyping was also performed. Immunoreactive alpha1-antitrypsin depos...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/68.6.736
更新日期:1977-12-01 00:00:00
abstract::Intrauterine clostridial infections have historically been associated with puerperal sepsis, often subsequent to instrumented abortions. Isolated reports have been associated with a malignant neoplasm or degenerating leiomyoma, most often after instrumentation, radiation therapy, or chemotherapy. In these cases, well-...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/91.1.104
更新日期:1989-01-01 00:00:00
abstract::Two unusual cases of acute lymphoblastic leukemia-hand mirror variant (ALL-HMV) are presented. One patient demonstrated a mixed immunophenotype with HLA-DR, My7, transferrin receptor surface markers, and terminal deoxynucleotidyl transferase positivity. To the authors' knowledge, this is the first ALL-HMV reported wit...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/91.4.410
更新日期:1989-04-01 00:00:00