Hepatitis B (surface) antigen testing by radioimmunoassaymexperience in a very large volunteer donor population.

Abstract:

:The results of hepatitis B surface antigen (HBs-Ag) testing in a large volunteer blood donor population are described. Counterelectrophoresis and three versions of solid-phase radioimmunoassay technic are compared and evaluated. Initial results suggested that the radioimmunoassay technic are compared and evaluated. Initial results suggested that the radioimmunoassay technic detected more than five times as many reactive donors as did counterelectrophoresis. The specificity of the radioimmunoassay technic has been increased by successive modifications, and recent results show that the technic detects 73 percent more reactive donors than does counterelectrophoresis. Not all of these reactions are specific, and it is estimated that the true gain in detection of HBsAg carriers is 49 percent of the value found by counterelectroesis. The incidence of HBsAg carriers in the America Red Cross donor population is about 1.25 per 1,000.

journal_name

Am J Clin Pathol

authors

Dodd RY,Ni LY,Mallin WS,Greenwalt TJ

doi

10.1093/ajcp/63.6.847

subject

Has Abstract

pub_date

1975-06-01 00:00:00

pages

847-53

issue

6

eissn

0002-9173

issn

1943-7722

journal_volume

63

pub_type

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