Value of p63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis of poorly differentiated and undifferentiated carcinomas.

abstract：OBJECTIVES:Pathogenic free-living amebae (FLAs) cause skin, ocular, and central nervous system (CNS) infections with significant morbidity and mortality. Diagnosis of FLA infections by pathologic examination of tissue sections can be aided using molecular assays. This study investigated the performance characteristics ...

journal_title：American journal of clinical pathology

authors： Norgan AP,Sloan LM,Pritt BS

更新日期：2019-11-04 00:00:00

abstract：:We describe a method of spectrophotometric detection of BCR/ABL chimeric sequences amplified by multiplex reverse transcriptase-polymerase chain reaction (RT-PCR), enabling the use of archival hematologic slides as RNA sources. Multiplex PCR amplified b3a2, b2a2, and e1a2 break points of the BCR/ABL translocation and ...

journal_title：American journal of clinical pathology

authors： Attadia V,Alosi M,Improta S,Zagonel V,Martinazzo G,Carbone A,Pinto A

更新日期：1997-10-01 00:00:00

abstract：:One hundred eighty-three patients with endometrial carcinoma had both immunohistochemical and biochemical analysis of estrogen receptor (ER) and progesterone receptor (PR) content of the tumor. Biochemical analysis was done on a homogenate of uterine curettings; immunohistochemical stainings were done on formalin-fixe...

journal_title：American journal of clinical pathology

authors： Chambers JT,Carcangiu ML,Voynick IM,Schwartz PE

更新日期：1990-09-01 00:00:00

abstract：:In this study, 145 well-differentiated (tubular) carcinomas were divided into two groups: 90 pure tubular carcinomas and 55 which were mixtures in that they contained a component of infiltrating duct carcinoma occupying less than half the tumor. Axillary lymph node metastases developed in 29% of women in the mixed gro...

journal_title：American journal of clinical pathology

authors： Deos PH,Norris HJ

更新日期：1982-07-01 00:00:00

abstract：OBJECTIVES:Human epidermal growth factor receptor 2 (HER2, ERBB2) testing is an important prognostic/predictive marker in breast cancer management, especially in selecting HER2-targeted treatment. American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines address HER2 status and were...

journal_title：American journal of clinical pathology

authors： Long TH,Lawce H,Durum C,Moore SR,Olson SB,Gatter K,Troxell ML

更新日期：2015-08-01 00:00:00

abstract：:Using Venn diagrams derived from set theory, a mathematic model is presented that allows triple-label immunophenotypic analysis of cells based upon double-label measurements. Practical applications of this method are illustrated and discussed. Using this model, triple-label data concerning Leu-8 and Leu-9 (CD7) antige...

journal_title：American journal of clinical pathology

authors： Wood GS

更新日期：1989-07-01 00:00:00

abstract：:The ability of the cervical Papanicolaou (Pap) smear to detect cervicitis associated with Chlamydia trachomatis was investigated. Cultures and cervical cytology samples were obtained from 487 women seen at the Mayo Clinic Department of Obstetrics and Gynecology and at the Sexually Transmitted Disease clinic of the Olm...

journal_title：American journal of clinical pathology

authors： Dorman SA,Danos LM,Wilson DJ,Noller KL,Malkasian GD,Goellner JR,Smith TF

更新日期：1983-04-01 00:00:00

abstract：:Anti-glomerular basement membrane (anti-GBM) glomerulonephritis is a rare disease caused by IgG autoantibodies against the glomerular basement membrane. We describe clinical and pathologic findings in a series of renal biopsy specimens from 80 patients. The patients ranged in age from 16 to 87 years. The age distribut...

journal_title：American journal of clinical pathology

authors： Fischer EG,Lager DJ

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVES:To determine the impact of implementing p16 Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions (LAST) guidelines, we compared p16 use and follow-up data before and after implementation of the guidelines. METHODS:We reviewed all cervical biopsy specimens diagnosed by two...

journal_title：American journal of clinical pathology

authors： Clinton LK,Miyazaki K,Ayabe A,Davis J,Tauchi-Nishi P,Shimizu D

更新日期：2015-12-01 00:00:00

abstract：:Pathologists are expected to accurately diagnose increasingly smaller breast carcinomas. Correct classification (ie, lobular vs ductal or in situ vs invasive) directly affects subsequent management, especially when the focus is near a surgical margin or present in a needle core biopsy and is further challenging if the...

journal_title：American journal of clinical pathology

authors： Ross DS,Liu YF,Pipa J,Shin SJ

更新日期：2013-01-01 00:00:00

abstract：:Previous reports have indicated that patients with severe acute respiratory syndrome (SARS)-associated coronavirus infection could develop atypical pneumonia with fulminant pulmonary edema. However, the target cells of SARS viral infection have not been characterized in detail. We report the pathologic findings of the...

journal_title：American journal of clinical pathology

authors： Chow KC,Hsiao CH,Lin TY,Chen CL,Chiou SH

更新日期：2004-04-01 00:00:00

abstract：:B5 fixation achieves superior morphologic detail. However, environmental concerns have led to labor-intensive and costly requirements for disposal of mercury-containing fixatives. We performed a blinded prospective study to find a safe, mercury-free alternative to B5. Morphology was evaluated with 6 fixatives, includi...

journal_title：American journal of clinical pathology

authors： Bonds LA,Barnes P,Foucar K,Sever CE

更新日期：2005-08-01 00:00:00

abstract：:Borrelia burgdorferi is difficult to detect in routine biopsy material from patients with skin lesions of borreliosis. In this study, a new immunohistochemical method, focus floating microscopy (FFM), was developed to detect B burgdorferi in tissue sections and was compared with polymerase chain reaction (PCR). By usi...

journal_title：American journal of clinical pathology

authors： Eisendle K,Grabner T,Zelger B

更新日期：2007-02-01 00:00:00

abstract：:Immunocytochemical assays for progesterone receptor (PR) using monoclonal antirabbit PR antibodies (PR-ICA) and for estrogen receptor (ER) (ER-ICA) were compared with radioligand binding (dextran-coated charcoal [DCC]) methods for receptor determination in patients with breast cancer. Immunocytochemical staining for P...

journal_title：American journal of clinical pathology

authors： Seymour L,Meyer K,Esser J,MacPhail AP,Behr A,Bezwoda WR

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVES:To describe the histopathologic and immunophenotypic features of a temporary splenic allograft exposed to massive donor-specific antibody (DSA) insult. METHODS:A human cadaveric donor splenic allograft was temporarily transplanted in a highly sensitized patient with the intention of removing DSA before inte...

journal_title：American journal of clinical pathology

authors： Gaitonde S,Hassan M,Mehta V,Benedetti E,Tzvetanov I,Lichvar A,Pirzada S,Setty S

更新日期：2020-11-21 00:00:00

abstract：:Cytology frequently has some role in preoperatively distinguishing pancreatic mucus-producing neoplasia (intraductal papillary mucinous neoplasms [IPMNs] and mucinous cystic neoplasms [MCNs]) from other pancreatic cysts. We evaluated all cytologic specimens at our institutions from resected pancreatic cystic lesions f...

journal_title：American journal of clinical pathology

authors： Stelow EB,Shami VM,Abbott TE,Kahaleh M,Adams RB,Bauer TW,Debol SM,Abraham JM,Mallery S,Policarpio-Nicolas ML

更新日期：2008-01-01 00:00:00

abstract：Objectives:To curtail inappropriate plasma transfusions, we instituted clinical decision support as an alert upon order entry if the patient's recent international normalized ratio (INR) was 1.7 or less. Methods:The alert was suppressed for massive transfusion and within operative or apheresis settings. The plasma ord...

journal_title：American journal of clinical pathology

authors： Shah N,Baker SA,Spain D,Shieh L,Shepard J,Hadhazy E,Maggio P,Goodnough LT

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:Peritoneal mesothelial cysts have been reported under various terms, including benign cystic mesothelioma, usually in the form of case reports/series, whereas extraperitoneal cases are rarely reported. Our objective was to report the detailed characteristics of cystic lesions of the serosal cavities. METHOD...

journal_title：American journal of clinical pathology

authors： Karpathiou G,Casteillo F,Dridi M,Peoc'h M

更新日期：2020-12-01 00:00:00

abstract：:Loss of intercellular adhesion facilitates tumor invasion. To clarify the relation between altered expression of cell adhesion molecules and progression of T1 superficial bladder tumors, 101 cases (71 T1 tumors, 30 T2/T3 tumors) were examined immunohistochemically for E-cadherin and alpha-, beta-, and gamma-catenins. ...

journal_title：American journal of clinical pathology

authors： Clairotte A,Lascombe I,Fauconnet S,Mauny F,Félix S,Algros MP,Bittard H,Kantelip B

更新日期：2006-01-01 00:00:00

abstract：:Hemizygous TP53 gene deletion is the most important adverse risk factor in chronic lymphocytic leukemia (CLL), but its relationship with p53 protein expression is unclear. We investigated 110 CLL cases and correlated nuclear p53 protein immunoreactivity with TP53 gene deletion status and other CLL-associated genetic r...

journal_title：American journal of clinical pathology

authors： Chang H,Jiang AM,Qi CX

更新日期：2010-01-01 00:00:00

abstract：:The Auto Microbic System (AMS) is an almost completely automated system, capable of identifying Enterobacteriaceae after 8 hours, and some glucose nonfermenters after 13 hours of incubation. The Autobac ID system is a mechanized, computer-assisted system capable of identifying Enterobacteriaceae and many nonfermentati...

journal_title：American journal of clinical pathology

authors： Barry AL,Gavan TL,Badal RE,Telenson MJ

更新日期：1982-10-01 00:00:00

abstract：:This article describes the seventh known case of blue nevus of the lymph node capsule and reviews the previously reported cases. The migration arrest hypothesis as an explanation for the occurrence of this lesion is favored rather than the "benign metastasis" hypothesis. The importance of the recognition of this pheno...

journal_title：American journal of clinical pathology

authors： Lamovec J

更新日期：1984-03-01 00:00:00

abstract：:Recent studies in Western populations have shown that trisomy 3 is the most frequent chromosomal abnormality in primary gastric lymphoma (PGL). To study the incidence of trisomy 3 and its implications for the pathogenesis of PGL in Hong Kong, we have applied the technique of chromosome in situ hybridization in 13 case...

journal_title：American journal of clinical pathology

authors： Zhang Y,Cheung AN,Chan AC,Shen DH,Xu WS,Chung LP,Ho FC

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVES:Lymphoid enhancer binding factor 1 (LEF1) is expressed in most cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and has shown utility in distinguishing CLL/SLL from other small B-cell lymphomas. LEF1 expression has not been systematically studied in CD5-positive marginal zone lympho...

journal_title：American journal of clinical pathology

authors： Patel N,Durkin L,Bodo J,Hsi ED

更新日期：2020-04-15 00:00:00

abstract：:Eosinophils are normally absent from the urine. Their presence has been associated with a variety of clinical conditions affecting the kidney or urinary tract. The authors examined the clinical significance and eosinophils, in particular, for acute interstitial nephritis. ...

journal_title：American journal of clinical pathology

authors： Corwin HL,Haber MH

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVES:Mesothelin (MSLN) is a differentiation antigen found to be overexpressed in intraductal papillary mucinous neoplasms (IPMNs) and is a potential treatment target in pancreatic ductal adenocarcinoma. METHODS:From institutional archives, 114 cases of resected pancreatic mucinous cysts were identified, includin...

journal_title：American journal of clinical pathology

authors： Frank R,Li S,Ahmad NA,Sepulveda AR,Jhala NC

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:To determine the current state of pathology resident training in genomic and molecular pathology. METHODS:The Training Residents in Genomics (TRIG) Working Group developed survey and knowledge questions for the 2013 pathology Resident In-Service Examination (RISE). Sixteen demographic questions related to a...

journal_title：American journal of clinical pathology

authors： Haspel RL,Rinder HM,Frank KM,Wagner J,Ali AM,Fisher PB,Parks ER,Training Residents in Genomics (TRIG) Working Group.

更新日期：2014-10-01 00:00:00

abstract：:A three-and-a-half-year old boy suffering from streptococcal pneumonia developed hemolytic-uremic syndrome and disseminated intravascular coagulation (DIC). His red blood cells (RBC) were shown to be T- and Tk-activated; serial testing showed his mature RBCs as well as neocytes remained T-activated at 40 days. Anti-T ...

journal_title：American journal of clinical pathology

authors： Beattie KM,Lewis PE,Briski JE,Strauch BM

更新日期：1985-08-01 00:00:00

abstract：Objectives:Early and accurate diagnosis remains crucial in the therapeutic management of invasive central nervous system fungal infections. Different molds have intrinsic resistance to antifungal agents; thus, morphologic differentiation is helpful to clinicians. Methods:Using three examples, we present a guide on how...

journal_title：American journal of clinical pathology

authors： Chavez JA,Brat DJ,Hunter SB,Velazquez Vega J,Guarner J

更新日期：2018-01-29 00:00:00

abstract：OBJECTIVES:Solid tumor metastases to the pancreas are rare, and only limited literature on the topic is available. In this retrospective study, we reviewed 107 cases of solid tumor metastases to the pancreas diagnosed by fine-needle aspiration (FNA) from 2005 to 2019. METHODS:Information including the patients' clinic...

journal_title：American journal of clinical pathology

authors： Hou T,Stewart JM,Lee JH,Gan Q

更新日期：2020-10-13 00:00:00