Dual use of E-cadherin and D2-40 immunostaining in unusual meningioma subtypes.

Abstract:

OBJECTIVES:Meningiomas usually can be readily diagnosed on H&E alone, although occasionally immunohistochemistry (IHC) confirmation is desirable. Studies exploring the diagnostic utility of either podoplanin (D2-40) or E-cadherin IHC in meningiomas have conflicted, and no studies exist in which the two IHCs have been used in combination for diagnosis. METHODS:E-cadherin and D2-40 IHC was performed on 77 meningiomas (31 ordinary; eight microcystic; four rare myxoid; six metaplastic; six invasive of orbit, muscle, and/or soft tissue; two metastatic; six brain-invasive World Health Organization [WHO] grade II, nine non-brain-invasive WHO grade II; and five anaplastic WHO grade III), with semi-quantitative scoring on a three-tier scale (0, focal [1+], strong/diffuse [2+]). RESULTS:All meningiomas were either E-cadherin or D2-40 IHC+, with 69 of 77 showing dual immunostaining, most at the 2+ level. No downregulation of E-cadherin IHC was found in invasive or high-grade meningiomas. CONCLUSIONS:Dual E-cadherin/D2-40 IHC can supplement diagnosis of meningioma.

journal_name

Am J Clin Pathol

authors

Mrachek EK,Davis D,Kleinschmidt-DeMasters BK

doi

10.1309/AJCPSULJ6DW5REHR

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

923-34

issue

6

eissn

0002-9173

issn

1943-7722

pii

144/6/923

journal_volume

144

pub_type

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