The evaluation of estrogen receptor in primary breast carcinoma by computer-assisted image analysis.

abstract：OBJECTIVES:Millions of biospecimens will be collected during the coronavirus disease 2019 (COVID-19) pandemic. As learned from severe acute respiratory syndrome (SARS), proper biospecimen handling is necessary to prevent laboratory-related infections. METHODS:Centers for Disease Control and Prevention and World Health...

journal_title：American journal of clinical pathology

authors： Lankes HA,Makhlouf H

更新日期：2021-01-04 00:00:00

abstract：OBJECTIVES:To investigate metastasis associated in colon cancer 1 (MACC1) and MET expression in colorectal adenoma, Tis, early-stage invasive (T1 and T2), and advanced adenocarcinoma with liver metastasis using immunohistochemistry. METHODS:Ninety-three paraffin-embedded colorectal tumor specimens were immunohistochem...

journal_title：American journal of clinical pathology

authors： Ren B,Zakharov V,Yang Q,McMahon L,Yu J,Cao W

更新日期：2013-11-01 00:00:00

abstract：:After several transfusions with D-negative blood, an O Rh-negative women was apparently sensitized to the C and D antigens. In her prenatal workup, it became evident that she had in fact not been sensitized to D but to G, which initially appeared as anti-D plus anti-C. This sensitization pattern is an unusual occurren...

journal_title：American journal of clinical pathology

authors： Yesus YW,Akhter JE

更新日期：1985-12-01 00:00:00

abstract：:In a preliminary attempt to distinguish random intrinsic and methodologic variations of blood lipid levels from any that have possibly been induced by ingestion of vitamin E, blood samples were analyzed in duplicate for lipids several times before and during oral vitamin E administration. Three of eight subjects showe...

journal_title：American journal of clinical pathology

authors： Muckle TJ,Nazir DJ

更新日期：1989-02-01 00:00:00

abstract：:A new disposable bleeding time device (Hemalet) was tested in 20 normal individuals and 11 patients with various bleeding disorders. The results were compared with those of Simplate II. The mean bleeding time for normal individuals was 5.4 +/- 1.5 (mean +/- 1 SD) minutes by Hemalet and 5.8 +/- 1.4 (mean +/- 1 SD) minu...

journal_title：American journal of clinical pathology

authors： Toomey KC,Kim HC,Kosmin M,Saidi P

更新日期：1986-05-01 00:00:00

abstract：Objectives:To examine the relationship between the recently defined Gleason grade groups and prostate cancer-specific mortality. Methods:If the probability of prostate cancer-specific death is symbolized as P(PSD), the probability of biochemical failure is symbolized as P(BF), and the probability of prostate cancer-sp...

journal_title：American journal of clinical pathology

authors： Vollmer RT

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVES:The National Cancer Institute (NCI) National Clinical Trials Network performs phase II and III clinical trials, which increasingly rely on the submission of diagnostic formalin-fixed, paraffin-embedded tissue blocks for biomarker assessment. Simultaneously, advances in precision oncology require that clinica...

journal_title：American journal of clinical pathology

authors： Makhlouf H,Watson MA,Lankes HA,Weil C,Dickler M,Birrer M,Moskaluk C,Ramirez NC,Okby N,Alonsozana E,Barnes M,Goldman EB,Enos R,Lubensky I

更新日期：2020-01-02 00:00:00

abstract：:To study the distribution of lactate dehydrogenase (LDH-1) (H4) in normal, ischemic, and necrotic myocardium using the peroxidase-antiperoxidase technic, the authors studied formalin-fixed paraffin-embedded sections of human (n = 11) and canine (n = 28) myocardium. All normal control myocardium showed positive immunos...

journal_title：American journal of clinical pathology

authors： Herscher LL,Siegel RJ,Said JW,Edwalds GM,Moran MM,Fishbein MC

更新日期：1984-02-01 00:00:00

abstract：:An on-line computer-assisted pathology encoding and reportying system (CAPER) has been developed by the Department of Pathology and Laboratory of Computer Science of the Massachusetts General Hospital for a department of surgical pathology that processes more than 25,000 specimens yearly. CAPER performs clerical funct...

journal_title：American journal of clinical pathology

authors： Aller RD,Robboy SJ,Poitras JW,Altshuler BS,Cameron M,Prior MC,Miao S,Barnett GO

更新日期：1977-12-01 00:00:00

abstract：OBJECTIVES:To compare thromboelastography (TEG) tracings obtained from fresh and citrated whole-blood samples in patients on extracorporeal membrane oxygenation (ECMO) or after cardiopulmonary bypass and in healthy volunteers. METHODS:Samples of fresh and citrated whole blood were analyzed for 25 patients and 4 health...

journal_title：American journal of clinical pathology

authors： Gilman EA,Koch CD,Santrach PJ,Schears GJ,Karon BS

更新日期：2013-08-01 00:00:00

abstract：:A structure resembling a sulfur granule found in histologic sections of endometrium from patients with intrauterine contraceptive devices is described. It is distinguished from a true sulfur granule on morphologic grounds and is further characterized as a foreign substance, most probably fragments of the synthetic con...

journal_title：American journal of clinical pathology

authors： O'Brien PK,Roth-Moyo LA,Davis BA

更新日期：1981-06-01 00:00:00

abstract：:An automated calcium method based on o-cresolphthalein complexone chemistry and designed to be used in conjunction with the Beckman ASTRA systems (Beckman Instruments, Inc., Brea, CA) was evaluated. Day-to-day reproducibility studies yielded coefficients of variation ranging from 1.2 to 3.1%. Linearity was 5.0-15.5 mg...

journal_title：American journal of clinical pathology

authors： Hartmann AE,Lewis LR

更新日期：1984-08-01 00:00:00

abstract：:The demonstration of tartrate-resistant acid phosphatase (TRAP) activity has long been a cornerstone in the diagnosis of hairy cell leukemia (HCL). Recently a monoclonal antibody to this enzyme has been developed that can be used in an immunoperoxidase method on paraffin-embedded tissues. By using a peroxidase-labeled...

journal_title：American journal of clinical pathology

authors： Hoyer JD,Li CY,Yam LT,Hanson CA,Kurtin PJ

更新日期：1997-09-01 00:00:00

abstract：:Determination of hemoglobin A1c (HbA1c) is one of the most important monitoring procedures for long-term control of diabetes mellitus. Several analytical methods have been developed for the measurement of glycohemoglobin (GHb). Those most frequently used are ion-exchange chromatography for HbA1c and affinity chromatog...

journal_title：American journal of clinical pathology

authors： Hamwi A,Schweiger CR,Veitl M,Schmid R

更新日期：1995-07-01 00:00:00

abstract：:The relationship between immunohistochemically measured membranous expression of erbB-2 oncoprotein and prognosis in breast cancer is controversial, and the relationship between cytoplasmic positivity and prognosis has been minimally investigated. The clinical course of 300 women with infiltrating breast carcinoma, wh...

journal_title：American journal of clinical pathology

authors： Keshgegian AA,Cnaan A

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVES:A systematic review of the literature was performed to identify whether minimum formalin fixation time may be reduced for reliable immunohistochemical assessment of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). METHODS:PubMed, EMBASE, and the Cochra...

journal_title：American journal of clinical pathology

authors： Kalkman S,Barentsz MW,van Diest PJ

更新日期：2014-07-01 00:00:00

abstract：:The ability of the cervical Papanicolaou (Pap) smear to detect cervicitis associated with Chlamydia trachomatis was investigated. Cultures and cervical cytology samples were obtained from 487 women seen at the Mayo Clinic Department of Obstetrics and Gynecology and at the Sexually Transmitted Disease clinic of the Olm...

journal_title：American journal of clinical pathology

authors： Dorman SA,Danos LM,Wilson DJ,Noller KL,Malkasian GD,Goellner JR,Smith TF

更新日期：1983-04-01 00:00:00

abstract：:Fresh frozen plasma (FFP) normally requires about 45 min to thaw in a 37 degrees C water bath when placed inside an additional plastic overbag. That relatively prolonged time may result in non-utilization or delays in delivery of the product, especially, during emergency surgery. One report recommends the use of a mic...

journal_title：American journal of clinical pathology

authors： Westphal RG,Tindle B,Howard PL,Golden EA,Page GA

更新日期：1982-08-01 00:00:00

abstract：:The performance characteristics of the XE-2100 (Sysmex, Kobe, Japan) automated immature granulocyte (IG) count were studied. The automated IG count was compared with the manual morphology count and with a proposed reference flow cytometric count. The comparison data were analyzed by both least-squares and Passing-Babl...

journal_title：American journal of clinical pathology

authors： Fernandes B,Hamaguchi Y

更新日期：2007-09-01 00:00:00

abstract：:Nine human exocrine pancreatic adenocarcinomas were examined by serial sectioning and double- and triple-labeled immunohistochemical techniques with antibodies against chromogranin A, insulin, islet amyloid polypeptide, glucagon, somatostatin, pancreatic polypeptide, serotonin, pancreastatin, and neuron-specific enola...

journal_title：American journal of clinical pathology

authors： Pour PM,Permert J,Mogaki M,Fujii H,Kazakoff K

更新日期：1993-09-01 00:00:00

abstract：:Chicken pox, although common, is rarely associated with autoimmune hemolytic anemia. Reported here is the case of an 8-year-old boy who was found to have cold agglutinin disease and severe anemia several days after he contracted chicken pox. The cold agglutinin appeared to be a polyclonal immunoglobulin M antibody wit...

journal_title：American journal of clinical pathology

authors： Friedman HD,Dracker RA

更新日期：1992-01-01 00:00:00

abstract：:The diagnosis of myeloid leukemia cutis can be difficult, particularly in the context of an initial skin biopsy with a malignant hematopoietic neoplasm. We studied the immunohistochemical characteristics of 33 cases of myeloid leukemia cutis diagnosed at Stanford University Medical Center, Stanford, CA, 1996-2007, and...

journal_title：American journal of clinical pathology

authors： Cronin DM,George TI,Sundram UN

更新日期：2009-07-01 00:00:00

abstract：:The t(3;21)(q26.2;q22) translocation is rare in cases of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). We studied 17 patients with MDS/AML associated with t(3;21) and compared them with 17 patients with MDS associated with inv(3) (q21q26.2)/t(3;3)(q21;q26.2), because these entities share 3q26 locus ...

journal_title：American journal of clinical pathology

authors： Li S,Yin CC,Medeiros LJ,Bueso-Ramos C,Lu G,Lin P

更新日期：2012-07-01 00:00:00

abstract：:In 42 patients with locally advanced breast cancer treated with neoadjuvant chemotherapy followed by surgery and radiation therapy, the effects of chemotherapy on tumor architecture, morphometric nuclear and nucleolar characteristics, DNA ploidy, proliferation index measured by mitotic activity index, expression of di...

journal_title：American journal of clinical pathology

authors： Honkoop AH,Pinedo HM,De Jong JS,Verheul HM,Linn SC,Hoekman K,Wagstaff J,van Diest PJ

更新日期：1997-02-01 00:00:00

abstract：:A tumor of the larynx composed of a small infiltrating and well-differentiated squamous cell carcinoma and a large polypoid sarcomatous mass showing the histologic features of the malignant giant cell tumor of soft parts (MGCT) is reported. Other types of sarcomatous components have been described with squamous cell c...

journal_title：American journal of clinical pathology

authors： Alguacil-Garcia A,Alonso A,Pettigrew NM

更新日期：1984-09-01 00:00:00

abstract：:A case of epithelioid sarcoma in a 39-year-old woman who had metastatic lesions in her lung from a primary arm tumor is presented. A review of the literature and analysis of this case did not identify any specific light microscopic or immunohistochemical way to separate definitively the lung cytologic smear in this ca...

journal_title：American journal of clinical pathology

authors： Niemann TH,Bottles K

更新日期：1993-08-01 00:00:00

abstract：Objectives:To determine the impact of systemwide charge display on laboratory utilization. Methods:This was a randomized controlled trial with a baseline period and an intervention period. Tests were randomized to a control arm or an active arm. The maximum allowable Medicare reimbursement rate was displayed for tests...

journal_title：American journal of clinical pathology

authors： Schmidt RL,Colbert-Getz JM,Milne CK,Vargo DJ,Hussong JW,Hoidal JR,Markewitz BA,Walker BS,Kawamoto K

更新日期：2017-11-20 00:00:00

abstract：:Cryostat sections from fully developed papular lesions of lymphomatoid papulosis (histologic subtype A or B) have been examined by immunoenzymatic staining with 24 monoclonal antibodies against lymphoid cells and their subsets. The lesions demonstrated essentially identical cellular compositions and consisted of T-lym...

journal_title：American journal of clinical pathology

authors： Ralfkiaer E,Stein H,Wantzin GL,Thomsen K,Ralfkiaer N,Mason DY

更新日期：1985-11-01 00:00:00

abstract：Objectives:Early and accurate diagnosis remains crucial in the therapeutic management of invasive central nervous system fungal infections. Different molds have intrinsic resistance to antifungal agents; thus, morphologic differentiation is helpful to clinicians. Methods:Using three examples, we present a guide on how...

journal_title：American journal of clinical pathology

authors： Chavez JA,Brat DJ,Hunter SB,Velazquez Vega J,Guarner J

更新日期：2018-01-29 00:00:00

abstract：:During a three-year period, Staphylococcus aureus and Pseudomonas aeruginosa were the organisms most commonly isolated from blood cultures of burned children. Microorganisms were considered to contribute to the cause of death in 17 of 20 patients who died from various complications of thermal injuries. Pseudomonas aer...

journal_title：American journal of clinical pathology

authors： Smith RF,Linares HA,Jorgensen JH

更新日期：1975-04-01 00:00:00