Assay of Factor XII clotting activity in heparinized plasma.

Abstract:

:Clotting tests based upon the activated partial thromboplastin time are disturbed by heparin. This brief communication shows that Factor XII clotting activity in plasma samples heparinized in vitro and in vivo can be measured accurately by means of an aPTT-test using congenitally deficient substrate plasma when the plasma dilution buffer contains hexadimethrine bromide (Polybrene), 15 mg/L. This method of neutralizing heparin obviates more complicated procedures such as heparin adsorption to anion exchange resins.

journal_name

Am J Clin Pathol

authors

Lämmle B,Tran TH,Duckert F

doi

10.1093/ajcp/80.4.474

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

474-7

issue

4

eissn

0002-9173

issn

1943-7722

journal_volume

80

pub_type

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