Abstract：
:Systemic sclerosis (SSc, scleroderma) is a devastating, immune-mediated, multisystem disorder characterized by microvasculature damage, circulating autoantibodies, and fibroblast activation, leading to massive fibrosis of skin, vessels, muscles, and visceral organs. Scleroderma causes disability and death as the result of end-stage organ failure. At present, no specific diagnostic nor therapeutic tools are available to handle the disease. In spite of significant effort, the etiology and pathogenesis of SSc remain obscure and, consequently, the disease outcome is unpredictable. Several years ago, Murrell suggested a unifying hypothesis linking the pathogenesis of scleroderma to the generation of a large excess of reactive oxygen species. This hypothesis has been substantiated by several reports indicating the presence of an abnormal redox state in patients with scleroderma. This review will summarize the available evidence supporting the link between free radicals and the main pathological features of scleroderma.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Gabrielli A,Svegliati S,Moroncini G,Pomponio G,Santillo M,Avvedimento EVdoi
10.1007/s00281-008-0125-4subject
Has Abstractpub_date
2008-07-01 00:00:00pages
329-37issue
3eissn
1863-2297issn
1863-2300journal_volume
30pub_type
杂志文章,评审abstract：:Ulcerative colitis designates an idiopathic chronic inflammatory bowel disease leading to bloody diarrhea and inflammatory alterations mostly restricted to the large intestine. Many studies continue to unravel important aspects of its etiopathogenesis, and recent pharmaceutical developments broaden the arsenal of ther...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-019-00751-6
更新日期：2019-11-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-011-0296-2
更新日期：2012-03-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-020-00831-y
更新日期：2021-01-07 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-013-0363-y
更新日期：2013-03-01 00:00:00
abstract：:The central nervous system (CNS) is tightly sealed from the changeable milieu of blood by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB). While the BBB is considered to be localized at the level of the endothelial cells within CNS microvessels, the BCSFB is established by choroid...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-009-0177-0
更新日期：2009-11-01 00:00:00
abstract：:The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-016-0561-5
更新日期：2016-07-01 00:00:00
abstract：:Why and how HIV makes people sick is highly debated. Recent evidence implicates heightened immune activation due to breakdown of the gastrointestinal barrier as a determining factor of lentiviral pathogenesis. HIV-mediated loss of Th17 cells from the gut-associated lymphoid tissue (GALT) impairs mucosal integrity and ...
journal_title：Seminars in immunopathology
pub_type： 杂志文章
doi：10.1007/s00281-009-0158-3
更新日期：2009-07-01 00:00:00
abstract：:Stronger adaptive immune responses in females can be observed in different mammals, resulting in better control of infections compared to males. However, this presumably evolutionary difference likely also drives higher incidence of autoimmune diseases observed in humans. Here, we summarize sex differences in the most...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-018-0723-8
更新日期：2019-03-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
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更新日期：2011-05-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-014-0463-3
更新日期：2015-03-01 00:00:00
abstract：:The profound alterations in the structure, cellular composition, and function of synovial tissue in rheumatoid arthritis (RA) are the basis for the persistent inflammation and cumulative joint destruction that are hallmarks of this disease. In RA, the synovium develops characteristics of a tertiary lymphoid organ, wit...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-017-0631-3
更新日期：2017-06-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-010-0201-4
更新日期：2010-06-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-019-00767-y
更新日期：2019-11-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0537-x
更新日期：2016-03-01 00:00:00
abstract：:Dendritic cells (DCs) operate at the intersection of the innate and adaptive immune systems. DCs can promote or inhibit adaptive immune responses against neuroantigens. While DC intrinsic properties, i.e., their maturation state or the subset they belong to, are important determinants of the outcome of an autoimmune r...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-016-0608-7
更新日期：2017-02-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-007-0100-5
更新日期：2008-02-01 00:00:00
abstract：:Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are two severe autoimmune bullous diseases of the mucosae and/or skin associated with autoantibodies directed against desmoglein (Dsg) 3 and/or Dsg1. These two desmosomal cadherins, typifying stratified epithelia, are components of cell adhesion complexes called des...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0541-1
更新日期：2016-01-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-010-0223-y
更新日期：2010-12-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0526-0
更新日期：2016-05-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-014-0420-1
更新日期：2014-03-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-010-0215-y
更新日期：2010-09-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-016-0613-x
更新日期：2017-04-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-020-00800-5
更新日期：2020-08-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0536-y
更新日期：2016-05-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-014-0443-7
更新日期：2014-11-01 00:00:00
abstract：:IgA nephropathy (IgAN) is the most common diagnosis amongst primary glomerular diseases in most countries where renal biopsies are regularly performed. Only a fraction of these patients is at high risk of losing glomerular filtration rate (GFR) in particular those with high grade proteinuria, uncontrolled hypertension...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-013-0411-7
更新日期：2014-07-01 00:00:00
abstract：:This issue of Seminars in Immunopathology is devoted to the most recent developments in our understanding of the mechanisms leading to tissue injury in autoimmune diseases. These include rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, autoimmune liver diseases, inflammatory bowel diseases, autoimm...
journal_title：Seminars in immunopathology
pub_type： 社论
doi：10.1007/s00281-014-0446-4
更新日期：2014-09-01 00:00:00
abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by synaptic dysfunction and accumulation of amyloid-beta (Aβ) peptide, which are responsible for the progressive loss of memory. The mechanisms involved in neuron dysfunction in AD remain poorly understood. Recent evidence implicates th...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-013-0373-9
更新日期：2013-05-01 00:00:00
abstract：:CD69 is an activation marker on leukocytes. Early studies showed that the CD69+ cells were detected in the lung of patients with asthmatic and eosinophilic pneumonia, suggesting that CD69 might play crucial roles in the pathogenesis of such inflammatory diseases, rather than simply being an activation marker. Intensiv...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-019-00734-7
更新日期：2019-05-01 00:00:00
abstract：:Fibrosis is a multicellular wound healing process, where myofibroblasts that express extracellular matrix components extensively cross-talk with other cells resident in the liver or recruited from the bloodstream. Macrophages and infiltrating monocytes participate in the development of fibrosis via several mechanisms,...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-009-0169-0
更新日期：2009-09-01 00:00:00
