Abstract:
:Checkpoint inhibitors blocking CTLA-4 (ipilimumab) and PD-1 (nivolumab, pembrolizumab) have transfigured our cancer treatment paradigm. However, these drugs can induce immune-related adverse events that share clinical and pathological characteristics with immune-mediated diseases. One of the most severe immune-related adverse event observed with anti-CTLA-4 is an enterocolitis that mirrors naturally occurring inflammatory bowel disease. This paper reviews the clinical, immunological, and microbiota data associated with the immune-related enterocolitis induced by the cancer immunotherapy blocking CTLA-4, ipilimumab. A parallel analysis of the mechanisms underlying inflammatory bowel diseases on the one hand, and anti-CTLA-4-induced colitis on the other hand, stresses the crucial role of the gut microbiota and of resident Treg in the genesis of both iatrogenic and spontaneous inflammatory bowel diseases.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Carbonnel F,Soularue E,Coutzac C,Chaput N,Mateus C,Lepage P,Robert Cdoi
10.1007/s00281-016-0613-xsubject
Has Abstractpub_date
2017-04-01 00:00:00pages
327-331issue
3eissn
1863-2297issn
1863-2300pii
10.1007/s00281-016-0613-xjournal_volume
39pub_type
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