Inflammatory bowel disease and cancer response due to anti-CTLA-4: is it in the flora?

Abstract:

:Checkpoint inhibitors blocking CTLA-4 (ipilimumab) and PD-1 (nivolumab, pembrolizumab) have transfigured our cancer treatment paradigm. However, these drugs can induce immune-related adverse events that share clinical and pathological characteristics with immune-mediated diseases. One of the most severe immune-related adverse event observed with anti-CTLA-4 is an enterocolitis that mirrors naturally occurring inflammatory bowel disease. This paper reviews the clinical, immunological, and microbiota data associated with the immune-related enterocolitis induced by the cancer immunotherapy blocking CTLA-4, ipilimumab. A parallel analysis of the mechanisms underlying inflammatory bowel diseases on the one hand, and anti-CTLA-4-induced colitis on the other hand, stresses the crucial role of the gut microbiota and of resident Treg in the genesis of both iatrogenic and spontaneous inflammatory bowel diseases.

journal_name

Semin Immunopathol

authors

Carbonnel F,Soularue E,Coutzac C,Chaput N,Mateus C,Lepage P,Robert C

doi

10.1007/s00281-016-0613-x

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

327-331

issue

3

eissn

1863-2297

issn

1863-2300

pii

10.1007/s00281-016-0613-x

journal_volume

39

pub_type

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