The resolution of inflammation through omega-3 fatty acids in atherosclerosis, intimal hyperplasia, and vascular calcification.

abstract：:Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are two severe autoimmune bullous diseases of the mucosae and/or skin associated with autoantibodies directed against desmoglein (Dsg) 3 and/or Dsg1. These two desmosomal cadherins, typifying stratified epithelia, are components of cell adhesion complexes called des...

journal_title：Seminars in immunopathology

authors： Di Zenzo G,Amber KT,Sayar BS,Müller EJ,Borradori L

更新日期：2016-01-01 00:00:00

abstract：:Basophils and mast cells have long been known to play critical roles in allergic disease and in immunity against parasitic infection. Accumulated evidence also supports that basophils and mast cells have important roles in immune regulations, host defense against bacteria and viruses, and autoimmune diseases. However,...

journal_title：Seminars in immunopathology

authors： Huang H,Li Y,Liu B

更新日期：2016-09-01 00:00:00

abstract：:The liver is the central metabolic organ of the organism and is thus constantly exposed to gut-derived dietary and microbial antigens. The liver maintains homoeostatic tolerance to these mostly harmless antigens. However, the liver also functions as a barrier organ to harmful pathogens and is thus permissive to liver ...

journal_title：Seminars in immunopathology

authors： Carambia A,Herkel J

更新日期：2018-02-01 00:00:00

abstract：:Unfortunately, an error occurred in the following passus of the article. The word "receptor" was missing in the sentence "Because T cells do not express GM-CSF receptor [41], GM-CSF affects non-T cells." ...

journal_title：Seminars in immunopathology

authors： Yasuda K,Takeuchi Y,Hirota K

更新日期：2019-05-01 00:00:00

abstract：:Implanted devices are mainly used to improve impaired function or to replace missing anatomic structures. They are made of synthetic material or devitalized biological structures. In contrast to vital transplants, they are not rejected by the body. However, the host reacts against these foreign bodies, a process which...

journal_title：Seminars in immunopathology

authors： Zimmerli W,Sendi P

更新日期：2011-05-01 00:00:00

abstract：:Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly...

journal_title：Seminars in immunopathology

authors： Sun S,Dong X

更新日期：2016-05-01 00:00:00

abstract：:Fibrosis is a multicellular wound healing process, where myofibroblasts that express extracellular matrix components extensively cross-talk with other cells resident in the liver or recruited from the bloodstream. Macrophages and infiltrating monocytes participate in the development of fibrosis via several mechanisms,...

journal_title：Seminars in immunopathology

authors： Marra F,Aleffi S,Galastri S,Provenzano A

更新日期：2009-09-01 00:00:00

abstract：:Immunoglobulin G (IgG) molecules can have two completely opposing activities. They can be very potent pro-inflammatory mediators on the one hand, directing the effector functions of the innate immune system towards infected cells, tumor cells or healthy tissues in the case of autoimmune diseases. On the other hand, a ...

journal_title：Seminars in immunopathology

authors： Böhm S,Schwab I,Lux A,Nimmerjahn F

更新日期：2012-05-01 00:00:00

abstract：:The cryopyrin-associated periodic syndrome (CAPS) is a severity spectrum of rare diseases. CAPS comprises the three conditions previously described as familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disorder (NOMID), also known as chronic infanti...

journal_title：Seminars in immunopathology

authors： Kuemmerle-Deschner JB

更新日期：2015-07-01 00:00:00

abstract：:IL-9 was initially identified as a T cell growth factor with a potential oncogenic activity. Accordingly, IL-9 drives tumor growth in most hematological cancers. However, the links between IL-9 and cancer progression have been recently revisited following the discovery of TH9 cells. TH9 cells, which have been characte...

journal_title：Seminars in immunopathology

authors： Rivera Vargas T,Humblin E,Végran F,Ghiringhelli F,Apetoh L

更新日期：2017-01-01 00:00:00

abstract：:Infection by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb) is a major cause of morbidity and mortality worldwide. Slow progress has been made in lessening the impact of tuberculosis (TB) on human health, especially in parts of the world where Mtb is endemic. Due to the complexity of TB disease,...

journal_title：Seminars in immunopathology

authors： Kiran D,Podell BK,Chambers M,Basaraba RJ

更新日期：2016-03-01 00:00:00

abstract：:Ulcerative colitis designates an idiopathic chronic inflammatory bowel disease leading to bloody diarrhea and inflammatory alterations mostly restricted to the large intestine. Many studies continue to unravel important aspects of its etiopathogenesis, and recent pharmaceutical developments broaden the arsenal of ther...

journal_title：Seminars in immunopathology

authors： Neurath MF,Leppkes M

更新日期：2019-11-01 00:00:00

abstract：:This issue of Seminars in Immunopathology is devoted to the most recent developments in our understanding of the mechanisms leading to tissue injury in autoimmune diseases. These include rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, autoimmune liver diseases, inflammatory bowel diseases, autoimm...

journal_title：Seminars in immunopathology

authors： Eilat D

更新日期：2014-09-01 00:00:00

abstract：:Lung transplantation is the only therapeutic option for patients with end-stage pulmonary disorders. Despite the improvements in surgical techniques and immunosuppressive therapy, allograft function and long-term survival are limited by the development of chronic lung transplant rejection. In this review, we focus on ...

journal_title：Seminars in immunopathology

authors： Nakajima T,Palchevsky V,Perkins DL,Belperio JA,Finn PW

更新日期：2011-03-01 00:00:00

abstract：:Systemic sclerosis (SSc, scleroderma) is a devastating, immune-mediated, multisystem disorder characterized by microvasculature damage, circulating autoantibodies, and fibroblast activation, leading to massive fibrosis of skin, vessels, muscles, and visceral organs. Scleroderma causes disability and death as the resul...

journal_title：Seminars in immunopathology

authors： Gabrielli A,Svegliati S,Moroncini G,Pomponio G,Santillo M,Avvedimento EV

更新日期：2008-07-01 00:00:00

abstract：:The central nervous system (CNS) is tightly sealed from the changeable milieu of blood by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB). While the BBB is considered to be localized at the level of the endothelial cells within CNS microvessels, the BCSFB is established by choroid...

journal_title：Seminars in immunopathology

authors： Engelhardt B,Sorokin L

更新日期：2009-11-01 00:00:00

abstract：:Membranous nephropathy (MN) is a non-inflammatory organ-specific autoimmune disease which affects the kidney glomerulus, resulting in the formation of immune deposits on the outer aspect of the glomerular basement membrane, complement-mediated proteinuria, and severe renal failure in 30% of patients. In the last 10 ye...

journal_title：Seminars in immunopathology

authors： Debiec H,Ronco P

更新日期：2014-07-01 00:00:00

abstract：:Obesity represents a serious health problem as it is rapidly increasing worldwide. Obesity is associated with reduced healthspan and lifespan, decreased responses to infections and vaccination, and increased frequency of inflammatory conditions typical of old age. Obesity is characterized by increased fat mass and rem...

journal_title：Seminars in immunopathology

authors： Frasca D,Blomberg BB

更新日期：2020-10-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically studied for its role in environmental chemical-mediated toxicity and carcinogenicity. In the last 5 years, however, it has become clear that the AhR, presumably activated by endogenous ligand(s), plays an important role in immu...

journal_title：Seminars in immunopathology

authors： Sherr DH,Monti S

更新日期：2013-11-01 00:00:00

abstract：:Why and how HIV makes people sick is highly debated. Recent evidence implicates heightened immune activation due to breakdown of the gastrointestinal barrier as a determining factor of lentiviral pathogenesis. HIV-mediated loss of Th17 cells from the gut-associated lymphoid tissue (GALT) impairs mucosal integrity and ...

journal_title：Seminars in immunopathology

authors： Hofer U,Speck RF

更新日期：2009-07-01 00:00:00

abstract：:The major histocompatibility complex (MHC) glycoprotein family, also referred to as human leukocyte antigens, present endogenous and exogenous antigens to T lymphocytes for recognition and response. These molecules play a central role in enabling the immune system to distinguish self from non-self, which is the basis ...

journal_title：Seminars in immunopathology

authors： Ryan SO,Cobb BA

更新日期：2012-05-01 00:00:00

abstract：:The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase of phagocytes is a multi-component electron transferase that uses cytoplasmic NADPH to convert molecular oxygen to superoxide anion, consequently delivering reactive oxygen species to the site of invading microorganisms. Together with soluble factors and ...

journal_title：Seminars in immunopathology

authors： Nauseef WM

更新日期：2008-07-01 00:00:00

abstract：:As predicted by the red queen hypothesis, microbial pathogens are probably the major reason for the evolution of the immune system (Paterson et al., Nature 464:275-278, 2010). In general, at the population level, i.e., for most of us, most of the time, the immune response to infection is highly effective. However, the...

journal_title：Seminars in immunopathology

authors： Garside P,Brewer J

更新日期：2010-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and seventh in women, accounting for 7 % of all cancers, and the third cause of cancer-related death worldwide. Nearly 90 to 95 % of all HCC occur in the context of known and often preventable risk factors, such as chronic viral hepatitis, alcohol a...

journal_title：Seminars in immunopathology

authors： Aghemo A,Colombo M

更新日期：2013-01-01 00:00:00

abstract：:Autophagy, a catabolic process involved in the sequestration and lysosomal degradation of cytoplasmic contents, is crucial for cellular homeostasis. The current literature supports that autophagy plays diverse roles in the development, maintenance, and progression of tumors. While genetic evidence indicates autophagy ...

journal_title：Seminars in immunopathology

authors： Roy S,Debnath J

更新日期：2010-12-01 00:00:00

abstract：:Originally identified as a response to starvation in yeast, autophagy is now understood to fulfill a variety of roles in higher eukaryotes, from the maintenance of cellular homeostasis to the cellular response to stress, starvation, and infection. Although genetics and biochemical studies in yeast have identified many...

journal_title：Seminars in immunopathology

authors： Zirin J,Perrimon N

更新日期：2010-12-01 00:00:00

abstract：:Food allergy is an increasingly prevalent disease of immune dysregulation directed to a small subset of proteins. Shared structural and functional features of allergens, such as glycosylation, lipid-binding and protease activity may provide insight into the mechanisms involved in the induction of primary Th2 immune re...

journal_title：Seminars in immunopathology

authors： Ruiter B,Shreffler WG

更新日期：2012-09-01 00:00:00

abstract：:Asthma is a common, complex, multifaceted disease. It comprises multiple phenotypes, which might benefit from treatment with different types of innovative targeted therapies. Refining these phenotypes and understanding their underlying biological structure would help to apply precision medicine approaches. Using diffe...

journal_title：Seminars in immunopathology

authors： Abdel-Aziz MI,Neerincx AH,Vijverberg SJ,Kraneveld AD,Maitland-van der Zee AH

更新日期：2020-02-01 00:00:00

abstract：:Despite considerable advances in the research and treatment, the precise relationship between inflammation and cardiovascular (CV) disease remains incompletely understood. Therefore, understanding the immunoinflammatory processes underlying the initiation, progression, and exacerbation of many cardiovascular diseases ...

journal_title：Seminars in immunopathology

authors： Numata T,Takahashi K,Inoue R

更新日期：2016-05-01 00:00:00

abstract：:In autoinflammatory disorders, dysregulation of the innate immune response leads to an excessive cytokine release. The disease course is often characterized by high morbidity and mortality, treatment is mostly difficult and therapeutic options are limited. In most cases, life-long control of ongoing inflammation is ne...

journal_title：Seminars in immunopathology

authors： Kallinich T

更新日期：2015-07-01 00:00:00