Abstract:
:A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine phosphatase (LYP), a critical negative modulator of TCR signaling encoded by the PTPN22 gene. The functional analysis of autoimmune-associated PTPN22 genetic variants suggests that genetic variability of TCR signal transduction contributes to the pathogenesis of autoimmunity in humans.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Stanford SM,Mustelin TM,Bottini Ndoi
10.1007/s00281-010-0201-4subject
Has Abstractpub_date
2010-06-01 00:00:00pages
127-36issue
2eissn
1863-2297issn
1863-2300journal_volume
32pub_type
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