Disturbance of the gut-associated lymphoid tissue is associated with disease progression in chronic HIV infection.

Abstract:

:Why and how HIV makes people sick is highly debated. Recent evidence implicates heightened immune activation due to breakdown of the gastrointestinal barrier as a determining factor of lentiviral pathogenesis. HIV-mediated loss of Th17 cells from the gut-associated lymphoid tissue (GALT) impairs mucosal integrity and innate defense mechanisms against gut microbes. Translocation of microbial products from the gut, in turn, correlates with increased immune activation in chronic HIV infection and may further damage the immune system by increasing viral and activation-induced T cell death, by reducing T cell reconstitution due to tissue scarring, and by impairing the function of other cell types, such as gammadelta T cells and epithelial cells. Maintaining a healthy GALT may be the key to reducing the pathogenic potential of HIV.

journal_name

Semin Immunopathol

authors

Hofer U,Speck RF

doi

10.1007/s00281-009-0158-3

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

257-66

issue

2

eissn

1863-2297

issn

1863-2300

journal_volume

31

pub_type

杂志文章
  • Resolution of Crohn's disease.

    abstract::Crohn's disease (CD) is characterized by chronic inflammation of the gastrointestinal tract and represents one of the main inflammatory bowel disease (IBD) forms. The infiltration of immune cells into the mucosa and uncontrolled production of pro-inflammatory cytokines and other mediators trigger the chronic inflammat...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-019-00756-1

    authors: Schmitt H,Neufert C,Neurath MF,Atreya R

    更新日期:2019-11-01 00:00:00

  • Adipose tissue, immune aging, and cellular senescence.

    abstract::Obesity represents a serious health problem as it is rapidly increasing worldwide. Obesity is associated with reduced healthspan and lifespan, decreased responses to infections and vaccination, and increased frequency of inflammatory conditions typical of old age. Obesity is characterized by increased fat mass and rem...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-020-00812-1

    authors: Frasca D,Blomberg BB

    更新日期:2020-10-01 00:00:00

  • Matricellular protein CCN1/CYR61: a new player in inflammation and leukocyte trafficking.

    abstract::Cystein-rich protein 61 (CYR61/CCN1) is a component of the extracellular matrix, which is produced and secreted by several cell types including endothelial cells, fibroblasts and smooth muscle cells. CCN1 has been implicated in leukocyte migration and the inflammatory process, but it is also involved in cardiovascular...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-014-0420-1

    authors: Emre Y,Imhof BA

    更新日期:2014-03-01 00:00:00

  • Effector CD8 T cell immunity in microsporidial infection: a lone defense mechanism.

    abstract::Microsporidia is a group of pathogens, which can pose severe risks to the immunocompromised population such as HIV-infected individuals. The expertise to diagnose these pathogens is limited and therefore their prevalence is believed to be much higher than what is currently known. In a mouse model of infections, it has...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-015-0482-8

    authors: Moretto MM,Harrow DI,Khan IA

    更新日期:2015-05-01 00:00:00

  • Pathogenesis of implant-associated infection: the role of the host.

    abstract::Implanted devices are mainly used to improve impaired function or to replace missing anatomic structures. They are made of synthetic material or devitalized biological structures. In contrast to vital transplants, they are not rejected by the body. However, the host reacts against these foreign bodies, a process which...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-011-0275-7

    authors: Zimmerli W,Sendi P

    更新日期:2011-05-01 00:00:00

  • Nox enzymes in immune cells.

    abstract::The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase of phagocytes is a multi-component electron transferase that uses cytoplasmic NADPH to convert molecular oxygen to superoxide anion, consequently delivering reactive oxygen species to the site of invading microorganisms. Together with soluble factors and ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-008-0117-4

    authors: Nauseef WM

    更新日期:2008-07-01 00:00:00

  • Recipe for IBD: can we use food to control inflammatory bowel disease?

    abstract::The mucosal immune system and the microbiota in the intestinal tract have recently been shown to play a key role in the pathogenesis of inflammatory bowel disease (IBD). Both of these can be influenced by food. Thus, we propose dietary intervention as a therapeutic option for IBD. In this review, we discuss the intera...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-017-0658-5

    authors: Witkowski M,Witkowski M,Gagliani N,Huber S

    更新日期:2018-02-01 00:00:00

  • Resolution of inflammation as a novel chemopreventive strategy.

    abstract::Acute inflammation, a physiologic response to protect cells from microbial infection and other noxious stimuli, is automatically terminated by endogenous anti-inflammatory and pro-resolving mediators to restore homeostatic conditions. However, if timely resolution of inflammation is failed, inflammation persists and c...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-013-0363-y

    authors: Lee HN,Na HK,Surh YJ

    更新日期:2013-03-01 00:00:00

  • Omics for the future in asthma.

    abstract::Asthma is a common, complex, multifaceted disease. It comprises multiple phenotypes, which might benefit from treatment with different types of innovative targeted therapies. Refining these phenotypes and understanding their underlying biological structure would help to apply precision medicine approaches. Using diffe...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-019-00776-x

    authors: Abdel-Aziz MI,Neerincx AH,Vijverberg SJ,Kraneveld AD,Maitland-van der Zee AH

    更新日期:2020-02-01 00:00:00

  • Inflammatory bowel disease and cancer response due to anti-CTLA-4: is it in the flora?

    abstract::Checkpoint inhibitors blocking CTLA-4 (ipilimumab) and PD-1 (nivolumab, pembrolizumab) have transfigured our cancer treatment paradigm. However, these drugs can induce immune-related adverse events that share clinical and pathological characteristics with immune-mediated diseases. One of the most severe immune-related...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-016-0613-x

    authors: Carbonnel F,Soularue E,Coutzac C,Chaput N,Mateus C,Lepage P,Robert C

    更新日期:2017-04-01 00:00:00

  • In vivo imaging of infection immunology--4I's!

    abstract::As predicted by the red queen hypothesis, microbial pathogens are probably the major reason for the evolution of the immune system (Paterson et al., Nature 464:275-278, 2010). In general, at the population level, i.e., for most of us, most of the time, the immune response to infection is highly effective. However, the...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-010-0215-y

    authors: Garside P,Brewer J

    更新日期:2010-09-01 00:00:00

  • In vitro immunogenicity of undifferentiated pluripotent stem cells (PSC) and derived lineages.

    abstract::The observation that embryonic stem cells (ESCs) expressed reduced levels of major histocompatibility (MHC) class I genes, no MHC class II or costimulatory molecules suggested early on that pluripotent stem cells (PSCs) could be "immune-privileged" and were unable to induce immune reactions. However, soon it became ap...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-011-0265-9

    authors: Kadereit S,Trounson A

    更新日期:2011-11-01 00:00:00

  • Regulating against the dysregulation: new treatment options in autoinflammation.

    abstract::In autoinflammatory disorders, dysregulation of the innate immune response leads to an excessive cytokine release. The disease course is often characterized by high morbidity and mortality, treatment is mostly difficult and therapeutic options are limited. In most cases, life-long control of ongoing inflammation is ne...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-015-0501-9

    authors: Kallinich T

    更新日期:2015-07-01 00:00:00

  • Auxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions.

    abstract::Activation and regulation of the cascade systems of the blood (the complement system, the coagulation/contact activation/kallikrein system, and the fibrinolytic system) occurs via activation of zymogen molecules to specific active proteolytic enzymes. Despite the fact that the generated proteases are all present toget...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-017-0646-9

    authors: Huber-Lang M,Ekdahl KN,Wiegner R,Fromell K,Nilsson B

    更新日期:2018-01-01 00:00:00

  • Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.

    abstract::A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine phosphatase (LYP), a critical ne...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-010-0201-4

    authors: Stanford SM,Mustelin TM,Bottini N

    更新日期:2010-06-01 00:00:00

  • Immunopathogenesis of membranous nephropathy: an update.

    abstract::Membranous nephropathy (MN) is a non-inflammatory organ-specific autoimmune disease which affects the kidney glomerulus, resulting in the formation of immune deposits on the outer aspect of the glomerular basement membrane, complement-mediated proteinuria, and severe renal failure in 30% of patients. In the last 10 ye...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-014-0423-y

    authors: Debiec H,Ronco P

    更新日期:2014-07-01 00:00:00

  • Sex differences in autoimmune disorders of the central nervous system.

    abstract::Stronger adaptive immune responses in females can be observed in different mammals, resulting in better control of infections compared to males. However, this presumably evolutionary difference likely also drives higher incidence of autoimmune diseases observed in humans. Here, we summarize sex differences in the most...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-018-0723-8

    authors: Gold SM,Willing A,Leypoldt F,Paul F,Friese MA

    更新日期:2019-03-01 00:00:00

  • Roles for major histocompatibility complex glycosylation in immune function.

    abstract::The major histocompatibility complex (MHC) glycoprotein family, also referred to as human leukocyte antigens, present endogenous and exogenous antigens to T lymphocytes for recognition and response. These molecules play a central role in enabling the immune system to distinguish self from non-self, which is the basis ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-012-0309-9

    authors: Ryan SO,Cobb BA

    更新日期:2012-05-01 00:00:00

  • Commensal microbiota regulates T cell fate decision in the gut.

    abstract::Commensal microbiota shapes the intestinal immune system by regulating T helper (TH) cell lineage differentiation. For example, Bacteroides fragilis colonization not only optimizes the systemic TH1/TH2 balance, but also can induce regulatory T (Treg) cell differentiation in the gut. In addition, segmented filamentous ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-014-0455-3

    authors: Furusawa Y,Obata Y,Hase K

    更新日期:2015-01-01 00:00:00

  • IL-9-producing cells in the development of IgE-mediated food allergy.

    abstract::Food allergy is a harmful immune reaction driven by uncontrolled type 2 immune responses. Considerable evidence demonstrates the key roles of mast cells, IgE, and TH2 cytokines in mediating food allergy. However, this evidence provides limited insight into why only some, rather than all, food allergic individuals are ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-016-0605-x

    authors: Shik D,Tomar S,Lee JB,Chen CY,Smith A,Wang YH

    更新日期:2017-01-01 00:00:00

  • The gut microbiota and inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gut. Although the precise cause of IBD remains unknown, the most accepted hypothesis of IBD pathogenesis to date is that an aberrant immune response against the gut microbiota is triggered by environmental factors in a genetically...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-014-0454-4

    authors: Matsuoka K,Kanai T

    更新日期:2015-01-01 00:00:00

  • Lupus erythematosus revisited.

    abstract::Lupus erythematosus (LE) is a multifactorial autoimmune disease with clinical manifestations of differing severity. The exact pathomechanisms and interactions resulting in the inflammatory and immunological processes of this heterogeneous disease remain elusive. Approaches in the understanding of the pathomechanisms r...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-015-0550-0

    authors: Kuhn A,Wenzel J,Bijl M

    更新日期:2016-01-01 00:00:00

  • Targeting the host-pathogen interface for treatment of Staphylococcus aureus infection.

    abstract::Recent emergence of methicillin-resistant Staphylococcus aureus both within and outside healthcare settings has accelerated the use of once reserved last line antibiotics such as vancomycin. With increased use of antibiotics, there has been a rapid rise in the rate of resistance development to the anti-MRSA drugs. As ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-011-0297-1

    authors: Park B,Liu GY

    更新日期:2012-03-01 00:00:00

  • Oxidative stress and the pathogenesis of scleroderma: the Murrell's hypothesis revisited.

    abstract::Systemic sclerosis (SSc, scleroderma) is a devastating, immune-mediated, multisystem disorder characterized by microvasculature damage, circulating autoantibodies, and fibroblast activation, leading to massive fibrosis of skin, vessels, muscles, and visceral organs. Scleroderma causes disability and death as the resul...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-008-0125-4

    authors: Gabrielli A,Svegliati S,Moroncini G,Pomponio G,Santillo M,Avvedimento EV

    更新日期:2008-07-01 00:00:00

  • Primary biliary cirrhosis.

    abstract::Primary biliary cirrhosis (PBC) is an immune-mediated chronic cholestatic liver disease with a slowly progressive course. Without treatment, most patients eventually develop fibrosis and cirrhosis of the liver and may need liver transplantation in the late stage of disease. PBC primarily affects women (female preponde...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-009-0164-5

    authors: Hohenester S,Oude-Elferink RP,Beuers U

    更新日期:2009-09-01 00:00:00

  • Interference of Aspergillus fumigatus with the immune response.

    abstract::Aspergillus fumigatus is a saprotrophic filamentous fungus and also the most prevalent airborne fungal pathogen of humans. Depending on the host's immune status, the variety of diseases caused by A. fumigatus ranges from allergies in immunocompetent hosts to life-threatening invasive infections in patients with impair...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-014-0465-1

    authors: Heinekamp T,Schmidt H,Lapp K,Pähtz V,Shopova I,Köster-Eiserfunke N,Krüger T,Kniemeyer O,Brakhage AA

    更新日期:2015-03-01 00:00:00

  • Introduction: mechanisms of tissue injury in autoimmune diseases.

    abstract::This issue of Seminars in Immunopathology is devoted to the most recent developments in our understanding of the mechanisms leading to tissue injury in autoimmune diseases. These include rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, autoimmune liver diseases, inflammatory bowel diseases, autoimm...

    journal_title:Seminars in immunopathology

    pub_type: 社论

    doi:10.1007/s00281-014-0446-4

    authors: Eilat D

    更新日期:2014-09-01 00:00:00

  • Dendritic cells in lung immunopathology.

    abstract::Dendritic cells (DCs) lie at the heart of the innate immune system, specialised at recognising danger signals in many forms including foreign material, infection or tissue damage and initiating powerful adaptive immune and inflammatory responses. In barrier sites such as the lung, the instrumental role that DCs play a...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-016-0571-3

    authors: Cook PC,MacDonald AS

    更新日期:2016-07-01 00:00:00

  • Autophagy and tumorigenesis.

    abstract::Autophagy, a catabolic process involved in the sequestration and lysosomal degradation of cytoplasmic contents, is crucial for cellular homeostasis. The current literature supports that autophagy plays diverse roles in the development, maintenance, and progression of tumors. While genetic evidence indicates autophagy ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-010-0213-0

    authors: Roy S,Debnath J

    更新日期:2010-12-01 00:00:00

  • Early life origin of type 1 diabetes.

    abstract::Type 1 diabetes (T1D) is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta cells in the pancreatic islets in genetically susceptible subjects. The incidence of T1D has increased manifold in most developed countries after World W...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-017-0665-6

    authors: Knip M,Luopajärvi K,Härkönen T

    更新日期:2017-11-01 00:00:00