Abstract:
:The theoretical physicist and Nobel laureate Richard Feynman outlined in his 1959 lecture, "There's plenty of room at the bottom", the enormous possibility of producing and visualising things at smaller scales. The advent of advanced scanning and transmission electron microscopy and high-resolution microscopy has begun to open the door to visualise host-pathogen interactions at smaller scales, and spinning disc confocal and two-photon microscopy has improved our ability to study these events in real time in three dimensions. The aim of this review is to illustrate some of the advances in understanding host-fungal interactions that have been made in recent years in particular those relating to the interactions of live fungal pathogens with phagocytes. Dynamic imaging of host-pathogen interactions has recently revealed novel detail and unsuspected mechanistic insights, facilitating the dissection of the phagocytic process into its component parts. Here, we will highlight advances in our knowledge of host-fungal pathogen interactions, including the specific effects of fungal cell viability, cell wall composition and morphogenesis on the phagocytic process and try to define the relative contributions of neutrophils and macrophages to the clearance of fungal pathogens in vitro and the infected host.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Bain J,Gow NA,Erwig LPdoi
10.1007/s00281-014-0463-3subject
Has Abstractpub_date
2015-03-01 00:00:00pages
131-9issue
2eissn
1863-2297issn
1863-2300journal_volume
37pub_type
杂志文章,评审abstract::The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a...
journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-014-0456-2
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abstract::LIGHT and herpes virus entry mediator (HVEM) comprise a ligand-receptor pair in the tumor necrosis factor superfamily. These molecules play an important role in regulating immunity, particularly in the intestinal mucosa. LIGHT also binds the lymphotoxin beta receptor, and HVEM can act as a ligand for immunoglobulin fa...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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更新日期:2016-07-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
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doi:10.1007/s00281-020-00800-5
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-011-0297-1
更新日期:2012-03-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-012-0309-9
更新日期:2012-05-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-012-0303-2
更新日期:2012-05-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-013-0415-3
更新日期:2014-07-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-016-0608-7
更新日期:2017-02-01 00:00:00
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.1007/s00281-019-00756-1
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-007-0089-9
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-017-0665-6
更新日期:2017-11-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-013-0373-9
更新日期:2013-05-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-013-0404-6
更新日期:2014-01-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-014-0420-1
更新日期:2014-03-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0526-0
更新日期:2016-05-01 00:00:00
abstract::Cytokines and growth factors are key regulators of immune activation, vascular alteration and excessive production of extracellular matrix which are hallmark events in the pathogenesis of systemic sclerosis (SSc). They modulate cell-cell and cell-matrix interactions. In particular, cytokines play a central role in the...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0511-7
更新日期:2015-09-01 00:00:00