Abstract:
:Recent studies have identified novel lymphocyte subsets named innate lymphoid cells (ILCs) lacking antigen-specific receptors. ILCs are present in a wide variety of epithelial compartments and occupy an intermediate position between acquired immune cells and myeloid cells. ILCs are now classified into three groups: group 1 ILC, group 2 ILC, and group 3 ILC based on their cytokine production patterns that correspond to the helper T cell subsets Th1, Th2, and Th17, respectively. ILCs play important roles in protection against various invading microbes including multicellular parasites, and in the maintenance of homeostasis and repair of epithelial layers. Excessive activation of ILCs, however, leads to various inflammatory disease conditions. ILCs have thus attracted interests of many researchers in the fields of infectious immunity, inflammatory diseases, and allergic diseases. Because epithelial cells sense alterations in environmental cues, it is important to understand the functional interaction between epithelial cells, ILCs, and environmental factors such as commensal microbiota. We discuss in this review developmental pathways of ILCs, their functions, and contribution of commensal microbiota to the differentiation and function of ILCs.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Moro K,Koyasu Sdoi
10.1007/s00281-014-0470-4subject
Has Abstractpub_date
2015-01-01 00:00:00pages
27-37issue
1eissn
1863-2297issn
1863-2300journal_volume
37pub_type
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
pub_type: 已发布勘误
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更新日期:2019-05-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2017-06-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
pub_type: 杂志文章
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journal_title:Seminars in immunopathology
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更新日期:2015-09-01 00:00:00
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