Drosophila as a model system to study autophagy.

abstract：:Stronger adaptive immune responses in females can be observed in different mammals, resulting in better control of infections compared to males. However, this presumably evolutionary difference likely also drives higher incidence of autoimmune diseases observed in humans. Here, we summarize sex differences in the most...

journal_title：Seminars in immunopathology

authors： Gold SM,Willing A,Leypoldt F,Paul F,Friese MA

更新日期：2019-03-01 00:00:00

abstract：:This issue of Seminars in Immunopathology is devoted to the most recent developments in our understanding of the mechanisms leading to tissue injury in autoimmune diseases. These include rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, autoimmune liver diseases, inflammatory bowel diseases, autoimm...

journal_title：Seminars in immunopathology

authors： Eilat D

更新日期：2014-09-01 00:00:00

abstract：:Autophagy, a catabolic process involved in the sequestration and lysosomal degradation of cytoplasmic contents, is crucial for cellular homeostasis. The current literature supports that autophagy plays diverse roles in the development, maintenance, and progression of tumors. While genetic evidence indicates autophagy ...

journal_title：Seminars in immunopathology

authors： Roy S,Debnath J

更新日期：2010-12-01 00:00:00

abstract：:Since life in a terrestrial environment threatens mammals continuously with desiccation, the structural, cellular, biochemical, and regulatory mechanisms that sustain permeability barrier homeostasis have justifiably comprised a major thrust of prior and recent research on epidermal barrier function. Yet, the epidermi...

journal_title：Seminars in immunopathology

authors： Elias PM

更新日期：2007-04-01 00:00:00

abstract：:Despite considerable advances in the research and treatment, the precise relationship between inflammation and cardiovascular (CV) disease remains incompletely understood. Therefore, understanding the immunoinflammatory processes underlying the initiation, progression, and exacerbation of many cardiovascular diseases ...

journal_title：Seminars in immunopathology

authors： Numata T,Takahashi K,Inoue R

更新日期：2016-05-01 00:00:00

abstract：:Malignant transformation of cells is often associated with changes in classical and non-classical HLA class I antigen, HLA class II antigen as well as NK cell activating ligand (NKCAL) expression. These changes are believed to play a role in the clinical course of the disease since these molecules are critical to the ...

journal_title：Seminars in immunopathology

authors： Campoli M,Ferrone S

更新日期：2011-07-01 00:00:00

abstract：:Lupus erythematosus (LE) is a multifactorial autoimmune disease with clinical manifestations of differing severity. The exact pathomechanisms and interactions resulting in the inflammatory and immunological processes of this heterogeneous disease remain elusive. Approaches in the understanding of the pathomechanisms r...

journal_title：Seminars in immunopathology

authors： Kuhn A,Wenzel J,Bijl M

更新日期：2016-01-01 00:00:00

abstract：:Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cer...

journal_title：Seminars in immunopathology

authors： Dai Y

更新日期：2016-05-01 00:00:00

abstract：:The major histocompatibility complex (MHC) glycoprotein family, also referred to as human leukocyte antigens, present endogenous and exogenous antigens to T lymphocytes for recognition and response. These molecules play a central role in enabling the immune system to distinguish self from non-self, which is the basis ...

journal_title：Seminars in immunopathology

authors： Ryan SO,Cobb BA

更新日期：2012-05-01 00:00:00

abstract：:Close association between chronic inflammation and cancer has been recently highlighted. Indeed, inflammatory bowel disease (IBD) has been strongly linked with an increased risk of development of colorectal cancer (CRC). Inflammatory cell-produced inflammatory mediators, such as proinflammatory cytokines and inducible...

journal_title：Seminars in immunopathology

authors： Tanaka T,Ishikawa H

更新日期：2013-03-01 00:00:00

abstract：:Activation and regulation of the cascade systems of the blood (the complement system, the coagulation/contact activation/kallikrein system, and the fibrinolytic system) occurs via activation of zymogen molecules to specific active proteolytic enzymes. Despite the fact that the generated proteases are all present toget...

journal_title：Seminars in immunopathology

authors： Huber-Lang M,Ekdahl KN,Wiegner R,Fromell K,Nilsson B

更新日期：2018-01-01 00:00:00

abstract：:Membranous nephropathy (MN) is a non-inflammatory organ-specific autoimmune disease which affects the kidney glomerulus, resulting in the formation of immune deposits on the outer aspect of the glomerular basement membrane, complement-mediated proteinuria, and severe renal failure in 30% of patients. In the last 10 ye...

journal_title：Seminars in immunopathology

authors： Debiec H,Ronco P

更新日期：2014-07-01 00:00:00

abstract：:Fibrosis is a multicellular wound healing process, where myofibroblasts that express extracellular matrix components extensively cross-talk with other cells resident in the liver or recruited from the bloodstream. Macrophages and infiltrating monocytes participate in the development of fibrosis via several mechanisms,...

journal_title：Seminars in immunopathology

authors： Marra F,Aleffi S,Galastri S,Provenzano A

更新日期：2009-09-01 00:00:00

abstract：:Intracellular pathogens need to develop sophisticated mechanisms to survive and thrive in the hostile environment within host cells. Unicellular, eukaryotic parasites from the Apicomplexa phylum have become masters of manipulating their host cells, exploiting signaling, and metabolic pathways to hijack host gene expre...

journal_title：Seminars in immunopathology

authors： Villares M,Berthelet J,Weitzman JB

更新日期：2020-04-01 00:00:00

abstract：:Asthma is a common, complex, multifaceted disease. It comprises multiple phenotypes, which might benefit from treatment with different types of innovative targeted therapies. Refining these phenotypes and understanding their underlying biological structure would help to apply precision medicine approaches. Using diffe...

journal_title：Seminars in immunopathology

authors： Abdel-Aziz MI,Neerincx AH,Vijverberg SJ,Kraneveld AD,Maitland-van der Zee AH

更新日期：2020-02-01 00:00:00

abstract：:The contact system is a plasma protease cascade that is initiated by coagulation factor XII activation on cardiovascular cells. The system starts procoagulant and proinflammatory reactions, via the intrinsic pathway of coagulation or the kallikrein-kinin system, respectively. The biochemistry of the contact system in ...

journal_title：Seminars in immunopathology

authors： Renné T

更新日期：2012-01-01 00:00:00

abstract：:Translational research generally refers to a "bench to bedside" approach where basic science discoveries in models move to clinical trials in humans. However, a "bedside to bench to bedside" approach may be more promising with respect to clinical relevance, since it starts with a clinical observation that can serve as...

journal_title：Seminars in immunopathology

authors： Gold SM,Voskuhl RR

更新日期：2016-11-01 00:00:00

abstract：:CD69 is an activation marker on leukocytes. Early studies showed that the CD69+ cells were detected in the lung of patients with asthmatic and eosinophilic pneumonia, suggesting that CD69 might play crucial roles in the pathogenesis of such inflammatory diseases, rather than simply being an activation marker. Intensiv...

journal_title：Seminars in immunopathology

authors： Kimura MY,Koyama-Nasu R,Yagi R,Nakayama T

更新日期：2019-05-01 00:00:00

abstract：:The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a...

journal_title：Seminars in immunopathology

authors： Caramori G,Casolari P,Barczyk A,Durham AL,Di Stefano A,Adcock I

更新日期：2016-07-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gut. Although the precise cause of IBD remains unknown, the most accepted hypothesis of IBD pathogenesis to date is that an aberrant immune response against the gut microbiota is triggered by environmental factors in a genetically...

journal_title：Seminars in immunopathology

authors： Matsuoka K,Kanai T

更新日期：2015-01-01 00:00:00

abstract：:Infection by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb) is a major cause of morbidity and mortality worldwide. Slow progress has been made in lessening the impact of tuberculosis (TB) on human health, especially in parts of the world where Mtb is endemic. Due to the complexity of TB disease,...

journal_title：Seminars in immunopathology

authors： Kiran D,Podell BK,Chambers M,Basaraba RJ

更新日期：2016-03-01 00:00:00

abstract：:Allergic asthma is a chronic inflammatory disease of the lower airways that affects millions of people worldwide. Allergic asthma is a T helper 2 cell (Th2)-mediated disease, in which Th2 cytokines interleukin (IL)-4, IL-5, and IL-13 are closely associated with the symptoms. IL-4 is needed by B cells to switch toward ...

journal_title：Seminars in immunopathology

authors： van Rijt L,von Richthofen H,van Ree R

更新日期：2016-07-01 00:00:00

abstract：:Obesity represents a serious health problem as it is rapidly increasing worldwide. Obesity is associated with reduced healthspan and lifespan, decreased responses to infections and vaccination, and increased frequency of inflammatory conditions typical of old age. Obesity is characterized by increased fat mass and rem...

journal_title：Seminars in immunopathology

authors： Frasca D,Blomberg BB

更新日期：2020-10-01 00:00:00

abstract：:Commensal microbiota shapes the intestinal immune system by regulating T helper (TH) cell lineage differentiation. For example, Bacteroides fragilis colonization not only optimizes the systemic TH1/TH2 balance, but also can induce regulatory T (Treg) cell differentiation in the gut. In addition, segmented filamentous ...

journal_title：Seminars in immunopathology

authors： Furusawa Y,Obata Y,Hase K

更新日期：2015-01-01 00:00:00

abstract：:Aspergillus fumigatus is a saprotrophic filamentous fungus and also the most prevalent airborne fungal pathogen of humans. Depending on the host's immune status, the variety of diseases caused by A. fumigatus ranges from allergies in immunocompetent hosts to life-threatening invasive infections in patients with impair...

journal_title：Seminars in immunopathology

authors： Heinekamp T,Schmidt H,Lapp K,Pähtz V,Shopova I,Köster-Eiserfunke N,Krüger T,Kniemeyer O,Brakhage AA

更新日期：2015-03-01 00:00:00

abstract：:Preterm birth, defined as delivery at less than 37 weeks' gestation, increases maternal-fetal morbidity and mortality and places heavy financial and emotional burdens on families and society. Although premature cervical remodeling is a major factor in many preterm deliveries, how and why this occurs is poorly understo...

journal_title：Seminars in immunopathology

authors： Pizzella S,El Helou N,Chubiz J,Wang LV,Tuuli MG,England SK,Stout MJ

更新日期：2020-08-01 00:00:00

abstract：:The cryopyrin-associated periodic syndrome (CAPS) is a severity spectrum of rare diseases. CAPS comprises the three conditions previously described as familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disorder (NOMID), also known as chronic infanti...

journal_title：Seminars in immunopathology

authors： Kuemmerle-Deschner JB

更新日期：2015-07-01 00:00:00

abstract：:Microsporidia is a group of pathogens, which can pose severe risks to the immunocompromised population such as HIV-infected individuals. The expertise to diagnose these pathogens is limited and therefore their prevalence is believed to be much higher than what is currently known. In a mouse model of infections, it has...

journal_title：Seminars in immunopathology

authors： Moretto MM,Harrow DI,Khan IA

更新日期：2015-05-01 00:00:00

abstract：:The intestine is normally colonized by a large and diverse commensal microbiota and is occasionally exposed to a variety of potential pathogens. In recent years, there has been substantial progress made in identifying molecular mechanisms that normally serve to protect the intestine from such enteric bacteria and whic...

journal_title：Seminars in immunopathology

authors： Vijay-Kumar M,Aitken JD,Gewirtz AT

更新日期：2008-02-01 00:00:00

abstract：:Acute inflammation, a physiologic response to protect cells from microbial infection and other noxious stimuli, is automatically terminated by endogenous anti-inflammatory and pro-resolving mediators to restore homeostatic conditions. However, if timely resolution of inflammation is failed, inflammation persists and c...

journal_title：Seminars in immunopathology

authors： Lee HN,Na HK,Surh YJ

更新日期：2013-03-01 00:00:00