Cytokines in the immunopathology of systemic sclerosis.

abstract：:Obesity represents a serious health problem as it is rapidly increasing worldwide. Obesity is associated with reduced healthspan and lifespan, decreased responses to infections and vaccination, and increased frequency of inflammatory conditions typical of old age. Obesity is characterized by increased fat mass and rem...

journal_title：Seminars in immunopathology

authors： Frasca D,Blomberg BB

更新日期：2020-10-01 00:00:00

abstract：:The liver is the central metabolic organ of the organism and is thus constantly exposed to gut-derived dietary and microbial antigens. The liver maintains homoeostatic tolerance to these mostly harmless antigens. However, the liver also functions as a barrier organ to harmful pathogens and is thus permissive to liver ...

journal_title：Seminars in immunopathology

authors： Carambia A,Herkel J

更新日期：2018-02-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically studied for its role in environmental chemical-mediated toxicity and carcinogenicity. In the last 5 years, however, it has become clear that the AhR, presumably activated by endogenous ligand(s), plays an important role in immu...

journal_title：Seminars in immunopathology

authors： Sherr DH,Monti S

更新日期：2013-11-01 00:00:00

abstract：:The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase of phagocytes is a multi-component electron transferase that uses cytoplasmic NADPH to convert molecular oxygen to superoxide anion, consequently delivering reactive oxygen species to the site of invading microorganisms. Together with soluble factors and ...

journal_title：Seminars in immunopathology

authors： Nauseef WM

更新日期：2008-07-01 00:00:00

abstract：:CD69 is an activation marker on leukocytes. Early studies showed that the CD69+ cells were detected in the lung of patients with asthmatic and eosinophilic pneumonia, suggesting that CD69 might play crucial roles in the pathogenesis of such inflammatory diseases, rather than simply being an activation marker. Intensiv...

journal_title：Seminars in immunopathology

authors： Kimura MY,Koyama-Nasu R,Yagi R,Nakayama T

更新日期：2019-05-01 00:00:00

abstract：:Infection by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb) is a major cause of morbidity and mortality worldwide. Slow progress has been made in lessening the impact of tuberculosis (TB) on human health, especially in parts of the world where Mtb is endemic. Due to the complexity of TB disease,...

journal_title：Seminars in immunopathology

authors： Kiran D,Podell BK,Chambers M,Basaraba RJ

更新日期：2016-03-01 00:00:00

abstract：:The central nervous system (CNS) is tightly sealed from the changeable milieu of blood by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB). While the BBB is considered to be localized at the level of the endothelial cells within CNS microvessels, the BCSFB is established by choroid...

journal_title：Seminars in immunopathology

authors： Engelhardt B,Sorokin L

更新日期：2009-11-01 00:00:00

abstract：:Substantial epidemiologic data have shown an increased risk of cardiovascular (CV) disease in rheumatoid arthritis (RA) patients. Traditional CV risk factors may partly contribute to CV disease in RA; however, current evidence underlines the important role of inflammation in the pathogenesis of atherosclerosis and amp...

journal_title：Seminars in immunopathology

authors： Lauper K,Gabay C

更新日期：2017-06-01 00:00:00

abstract：:Microsporidia is a group of pathogens, which can pose severe risks to the immunocompromised population such as HIV-infected individuals. The expertise to diagnose these pathogens is limited and therefore their prevalence is believed to be much higher than what is currently known. In a mouse model of infections, it has...

journal_title：Seminars in immunopathology

authors： Moretto MM,Harrow DI,Khan IA

更新日期：2015-05-01 00:00:00

abstract：:The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a...

journal_title：Seminars in immunopathology

authors： Caramori G,Casolari P,Barczyk A,Durham AL,Di Stefano A,Adcock I

更新日期：2016-07-01 00:00:00

abstract：:Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are two severe autoimmune bullous diseases of the mucosae and/or skin associated with autoantibodies directed against desmoglein (Dsg) 3 and/or Dsg1. These two desmosomal cadherins, typifying stratified epithelia, are components of cell adhesion complexes called des...

journal_title：Seminars in immunopathology

authors： Di Zenzo G,Amber KT,Sayar BS,Müller EJ,Borradori L

更新日期：2016-01-01 00:00:00

abstract：:Close association between chronic inflammation and cancer has been recently highlighted. Indeed, inflammatory bowel disease (IBD) has been strongly linked with an increased risk of development of colorectal cancer (CRC). Inflammatory cell-produced inflammatory mediators, such as proinflammatory cytokines and inducible...

journal_title：Seminars in immunopathology

authors： Tanaka T,Ishikawa H

更新日期：2013-03-01 00:00:00

abstract：:Translational research generally refers to a "bench to bedside" approach where basic science discoveries in models move to clinical trials in humans. However, a "bedside to bench to bedside" approach may be more promising with respect to clinical relevance, since it starts with a clinical observation that can serve as...

journal_title：Seminars in immunopathology

authors： Gold SM,Voskuhl RR

更新日期：2016-11-01 00:00:00

abstract：:The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world's population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation...

journal_title：Seminars in immunopathology

authors： Cohen Y,Stern-Ginossar N

更新日期：2014-11-01 00:00:00

abstract：:The cryopyrin-associated periodic syndrome (CAPS) is a severity spectrum of rare diseases. CAPS comprises the three conditions previously described as familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disorder (NOMID), also known as chronic infanti...

journal_title：Seminars in immunopathology

authors： Kuemmerle-Deschner JB

更新日期：2015-07-01 00:00:00

abstract：:Type 1 diabetes (T1D) is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta cells in the pancreatic islets in genetically susceptible subjects. The incidence of T1D has increased manifold in most developed countries after World W...

journal_title：Seminars in immunopathology

authors： Knip M,Luopajärvi K,Härkönen T

更新日期：2017-11-01 00:00:00

abstract：:Recent emergence of methicillin-resistant Staphylococcus aureus both within and outside healthcare settings has accelerated the use of once reserved last line antibiotics such as vancomycin. With increased use of antibiotics, there has been a rapid rise in the rate of resistance development to the anti-MRSA drugs. As ...

journal_title：Seminars in immunopathology

authors： Park B,Liu GY

更新日期：2012-03-01 00:00:00

abstract：:Autophagy, a catabolic process involved in the sequestration and lysosomal degradation of cytoplasmic contents, is crucial for cellular homeostasis. The current literature supports that autophagy plays diverse roles in the development, maintenance, and progression of tumors. While genetic evidence indicates autophagy ...

journal_title：Seminars in immunopathology

authors： Roy S,Debnath J

更新日期：2010-12-01 00:00:00

abstract：:Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell failure is a major component of the pathogenesis of type 2 diabetes. It is now well established that increased numbers of innate immune cells, cytokines, and chemokines have detrimental effects on islets in these chronic conditi...

journal_title：Seminars in immunopathology

authors： Böni-Schnetzler M,Meier DT

更新日期：2019-07-01 00:00:00

abstract：:Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly...

journal_title：Seminars in immunopathology

authors： Sun S,Dong X

更新日期：2016-05-01 00:00:00

abstract：:Commensal microbiota shapes the intestinal immune system by regulating T helper (TH) cell lineage differentiation. For example, Bacteroides fragilis colonization not only optimizes the systemic TH1/TH2 balance, but also can induce regulatory T (Treg) cell differentiation in the gut. In addition, segmented filamentous ...

journal_title：Seminars in immunopathology

authors： Furusawa Y,Obata Y,Hase K

更新日期：2015-01-01 00:00:00

abstract：:Dendritic cells (DCs) lie at the heart of the innate immune system, specialised at recognising danger signals in many forms including foreign material, infection or tissue damage and initiating powerful adaptive immune and inflammatory responses. In barrier sites such as the lung, the instrumental role that DCs play a...

journal_title：Seminars in immunopathology

authors： Cook PC,MacDonald AS

更新日期：2016-07-01 00:00:00

abstract：:Membranous nephropathy (MN) is a non-inflammatory organ-specific autoimmune disease which affects the kidney glomerulus, resulting in the formation of immune deposits on the outer aspect of the glomerular basement membrane, complement-mediated proteinuria, and severe renal failure in 30% of patients. In the last 10 ye...

journal_title：Seminars in immunopathology

authors： Debiec H,Ronco P

更新日期：2014-07-01 00:00:00

abstract：:Helicobacter pylori infection is an important factor for gastric carcinogenesis in human. In carcinogen-treated Mongolian gerbils, H. pylori infection enhances stomach carcinogenesis, while infection alone induced severe hyperplasia called heterotopic proliferative glands. A high-salt diet or early acquisition of the ...

journal_title：Seminars in immunopathology

authors： Tsukamoto T,Toyoda T,Mizoshita T,Tatematsu M

更新日期：2013-03-01 00:00:00

abstract：:Originally identified as a response to starvation in yeast, autophagy is now understood to fulfill a variety of roles in higher eukaryotes, from the maintenance of cellular homeostasis to the cellular response to stress, starvation, and infection. Although genetics and biochemical studies in yeast have identified many...

journal_title：Seminars in immunopathology

authors： Zirin J,Perrimon N

更新日期：2010-12-01 00:00:00

abstract：:O-fucosylglycans on Notch extracellular domain epidermal growth factor (EGF) repeats are critical in modulating Notch signaling by altering the sensitivity of Notch receptors to activation by Notch ligands. Mice lacking Notch O-fucosylglycans display granulo-monocytic myeloproliferation, hematopoietic stem cell dysfun...

journal_title：Seminars in immunopathology

authors： Zhou L

更新日期：2012-05-01 00:00:00

abstract：:In autoinflammatory disorders, dysregulation of the innate immune response leads to an excessive cytokine release. The disease course is often characterized by high morbidity and mortality, treatment is mostly difficult and therapeutic options are limited. In most cases, life-long control of ongoing inflammation is ne...

journal_title：Seminars in immunopathology

authors： Kallinich T

更新日期：2015-07-01 00:00:00

abstract：:The intestine is normally colonized by a large and diverse commensal microbiota and is occasionally exposed to a variety of potential pathogens. In recent years, there has been substantial progress made in identifying molecular mechanisms that normally serve to protect the intestine from such enteric bacteria and whic...

journal_title：Seminars in immunopathology

authors： Vijay-Kumar M,Aitken JD,Gewirtz AT

更新日期：2008-02-01 00:00:00

abstract：:Implanted devices are mainly used to improve impaired function or to replace missing anatomic structures. They are made of synthetic material or devitalized biological structures. In contrast to vital transplants, they are not rejected by the body. However, the host reacts against these foreign bodies, a process which...

journal_title：Seminars in immunopathology

authors： Zimmerli W,Sendi P

更新日期：2011-05-01 00:00:00

abstract：:Since life in a terrestrial environment threatens mammals continuously with desiccation, the structural, cellular, biochemical, and regulatory mechanisms that sustain permeability barrier homeostasis have justifiably comprised a major thrust of prior and recent research on epidermal barrier function. Yet, the epidermi...

journal_title：Seminars in immunopathology

authors： Elias PM

更新日期：2007-04-01 00:00:00