Abstract：
:The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched smokers with normal lung function has provided novel insights on the potential pathogenetic role of the different cells of the innate and acquired immune responses and their pro/anti-inflammatory mediators and intracellular signalling pathways, contributing to a better knowledge of the immunopathology of COPD both during its stable phase and during its exacerbations. This also has provided a scientific rationale for new drugs discovery and targeting to the lower airways. This review summarises and discusses the immunopathology of COPD patients, of different severity, compared with control smokers with normal lung function.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Caramori G,Casolari P,Barczyk A,Durham AL,Di Stefano A,Adcock Idoi
10.1007/s00281-016-0561-5subject
Has Abstractpub_date
2016-07-01 00:00:00pages
497-515issue
4eissn
1863-2297issn
1863-2300pii
10.1007/s00281-016-0561-5journal_volume
38pub_type
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