COPD immunopathology.


:The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a control group of age-matched smokers with normal lung function has provided novel insights on the potential pathogenetic role of the different cells of the innate and acquired immune responses and their pro/anti-inflammatory mediators and intracellular signalling pathways, contributing to a better knowledge of the immunopathology of COPD both during its stable phase and during its exacerbations. This also has provided a scientific rationale for new drugs discovery and targeting to the lower airways. This review summarises and discusses the immunopathology of COPD patients, of different severity, compared with control smokers with normal lung function.


Semin Immunopathol


Caramori G,Casolari P,Barczyk A,Durham AL,Di Stefano A,Adcock I




Has Abstract


2016-07-01 00:00:00














  • Resolution of Crohn's disease.

    abstract::Crohn's disease (CD) is characterized by chronic inflammation of the gastrointestinal tract and represents one of the main inflammatory bowel disease (IBD) forms. The infiltration of immune cells into the mucosa and uncontrolled production of pro-inflammatory cytokines and other mediators trigger the chronic inflammat...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Schmitt H,Neufert C,Neurath MF,Atreya R

    更新日期:2019-11-01 00:00:00

  • The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction.

    abstract::The central nervous system (CNS) is tightly sealed from the changeable milieu of blood by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB). While the BBB is considered to be localized at the level of the endothelial cells within CNS microvessels, the BCSFB is established by choroid...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Engelhardt B,Sorokin L

    更新日期:2009-11-01 00:00:00

  • Recipe for IBD: can we use food to control inflammatory bowel disease?

    abstract::The mucosal immune system and the microbiota in the intestinal tract have recently been shown to play a key role in the pathogenesis of inflammatory bowel disease (IBD). Both of these can be influenced by food. Thus, we propose dietary intervention as a therapeutic option for IBD. In this review, we discuss the intera...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Witkowski M,Witkowski M,Gagliani N,Huber S

    更新日期:2018-02-01 00:00:00

  • Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia.

    abstract::Human pregnancy is a metabolic and immune challenge for the mother who has to accommodate in her womb a semi-allogeneic fetus whose energy needs increase tremendously with gestation. Recent compelling research has suggested that proper inflammatory changes and oxidative balance are a requisite for successful pregnancy...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Rusterholz C,Hahn S,Holzgreve W

    更新日期:2007-06-01 00:00:00

  • Trp channels and itch.

    abstract::Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Sun S,Dong X

    更新日期:2016-05-01 00:00:00

  • Effector CD8 T cell immunity in microsporidial infection: a lone defense mechanism.

    abstract::Microsporidia is a group of pathogens, which can pose severe risks to the immunocompromised population such as HIV-infected individuals. The expertise to diagnose these pathogens is limited and therefore their prevalence is believed to be much higher than what is currently known. In a mouse model of infections, it has...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Moretto MM,Harrow DI,Khan IA

    更新日期:2015-05-01 00:00:00

  • Roles for major histocompatibility complex glycosylation in immune function.

    abstract::The major histocompatibility complex (MHC) glycoprotein family, also referred to as human leukocyte antigens, present endogenous and exogenous antigens to T lymphocytes for recognition and response. These molecules play a central role in enabling the immune system to distinguish self from non-self, which is the basis ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Ryan SO,Cobb BA

    更新日期:2012-05-01 00:00:00

  • Innate immunostimulatory properties of allergens and their relevance to food allergy.

    abstract::Food allergy is an increasingly prevalent disease of immune dysregulation directed to a small subset of proteins. Shared structural and functional features of allergens, such as glycosylation, lipid-binding and protease activity may provide insight into the mechanisms involved in the induction of primary Th2 immune re...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Ruiter B,Shreffler WG

    更新日期:2012-09-01 00:00:00

  • The role of sialic acid as a modulator of the anti-inflammatory activity of IgG.

    abstract::Immunoglobulin G (IgG) molecules can have two completely opposing activities. They can be very potent pro-inflammatory mediators on the one hand, directing the effector functions of the innate immune system towards infected cells, tumor cells or healthy tissues in the case of autoimmune diseases. On the other hand, a ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Böhm S,Schwab I,Lux A,Nimmerjahn F

    更新日期:2012-05-01 00:00:00

  • Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.

    abstract::LIGHT and herpes virus entry mediator (HVEM) comprise a ligand-receptor pair in the tumor necrosis factor superfamily. These molecules play an important role in regulating immunity, particularly in the intestinal mucosa. LIGHT also binds the lymphotoxin beta receptor, and HVEM can act as a ligand for immunoglobulin fa...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Steinberg MW,Shui JW,Ware CF,Kronenberg M

    更新日期:2009-07-01 00:00:00

  • Dietary and metabolic modulators of hepatic immunity.

    abstract::The liver is the central metabolic organ of the organism and is thus constantly exposed to gut-derived dietary and microbial antigens. The liver maintains homoeostatic tolerance to these mostly harmless antigens. However, the liver also functions as a barrier organ to harmful pathogens and is thus permissive to liver ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Carambia A,Herkel J

    更新日期:2018-02-01 00:00:00

  • Primary biliary cirrhosis.

    abstract::Primary biliary cirrhosis (PBC) is an immune-mediated chronic cholestatic liver disease with a slowly progressive course. Without treatment, most patients eventually develop fibrosis and cirrhosis of the liver and may need liver transplantation in the late stage of disease. PBC primarily affects women (female preponde...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Hohenester S,Oude-Elferink RP,Beuers U

    更新日期:2009-09-01 00:00:00

  • Matricellular protein CCN1/CYR61: a new player in inflammation and leukocyte trafficking.

    abstract::Cystein-rich protein 61 (CYR61/CCN1) is a component of the extracellular matrix, which is produced and secreted by several cell types including endothelial cells, fibroblasts and smooth muscle cells. CCN1 has been implicated in leukocyte migration and the inflammatory process, but it is also involved in cardiovascular...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Emre Y,Imhof BA

    更新日期:2014-03-01 00:00:00

  • Myeloproliferation and hematopoietic stem cell dysfunction due to defective Notch receptor modification by O-fucose glycans.

    abstract::O-fucosylglycans on Notch extracellular domain epidermal growth factor (EGF) repeats are critical in modulating Notch signaling by altering the sensitivity of Notch receptors to activation by Notch ligands. Mice lacking Notch O-fucosylglycans display granulo-monocytic myeloproliferation, hematopoietic stem cell dysfun...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Zhou L

    更新日期:2012-05-01 00:00:00

  • Islet inflammation in type 2 diabetes.

    abstract::Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell failure is a major component of the pathogenesis of type 2 diabetes. It is now well established that increased numbers of innate immune cells, cytokines, and chemokines have detrimental effects on islets in these chronic conditi...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Böni-Schnetzler M,Meier DT

    更新日期:2019-07-01 00:00:00

  • Omics for the future in asthma.

    abstract::Asthma is a common, complex, multifaceted disease. It comprises multiple phenotypes, which might benefit from treatment with different types of innovative targeted therapies. Refining these phenotypes and understanding their underlying biological structure would help to apply precision medicine approaches. Using diffe...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Abdel-Aziz MI,Neerincx AH,Vijverberg SJ,Kraneveld AD,Maitland-van der Zee AH

    更新日期:2020-02-01 00:00:00

  • Hepatocellular carcinoma in chronic hepatitis C: from bench to bedside.

    abstract::Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and seventh in women, accounting for 7 % of all cancers, and the third cause of cancer-related death worldwide. Nearly 90 to 95 % of all HCC occur in the context of known and often preventable risk factors, such as chronic viral hepatitis, alcohol a...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Aghemo A,Colombo M

    更新日期:2013-01-01 00:00:00

  • Pregnancy and multiple sclerosis: from molecular mechanisms to clinical application.

    abstract::Translational research generally refers to a "bench to bedside" approach where basic science discoveries in models move to clinical trials in humans. However, a "bedside to bench to bedside" approach may be more promising with respect to clinical relevance, since it starts with a clinical observation that can serve as...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Gold SM,Voskuhl RR

    更新日期:2016-11-01 00:00:00

  • Evolving cervical imaging technologies to predict preterm birth.

    abstract::Preterm birth, defined as delivery at less than 37 weeks' gestation, increases maternal-fetal morbidity and mortality and places heavy financial and emotional burdens on families and society. Although premature cervical remodeling is a major factor in many preterm deliveries, how and why this occurs is poorly understo...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Pizzella S,El Helou N,Chubiz J,Wang LV,Tuuli MG,England SK,Stout MJ

    更新日期:2020-08-01 00:00:00

  • The procoagulant and proinflammatory plasma contact system.

    abstract::The contact system is a plasma protease cascade that is initiated by coagulation factor XII activation on cardiovascular cells. The system starts procoagulant and proinflammatory reactions, via the intrinsic pathway of coagulation or the kallikrein-kinin system, respectively. The biochemistry of the contact system in ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Renné T

    更新日期:2012-01-01 00:00:00

  • Immunopathogenesis of membranous nephropathy: an update.

    abstract::Membranous nephropathy (MN) is a non-inflammatory organ-specific autoimmune disease which affects the kidney glomerulus, resulting in the formation of immune deposits on the outer aspect of the glomerular basement membrane, complement-mediated proteinuria, and severe renal failure in 30% of patients. In the last 10 ye...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Debiec H,Ronco P

    更新日期:2014-07-01 00:00:00

  • Pathogenesis of implant-associated infection: the role of the host.

    abstract::Implanted devices are mainly used to improve impaired function or to replace missing anatomic structures. They are made of synthetic material or devitalized biological structures. In contrast to vital transplants, they are not rejected by the body. However, the host reacts against these foreign bodies, a process which...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Zimmerli W,Sendi P

    更新日期:2011-05-01 00:00:00

  • Oxidative stress and the pathogenesis of scleroderma: the Murrell's hypothesis revisited.

    abstract::Systemic sclerosis (SSc, scleroderma) is a devastating, immune-mediated, multisystem disorder characterized by microvasculature damage, circulating autoantibodies, and fibroblast activation, leading to massive fibrosis of skin, vessels, muscles, and visceral organs. Scleroderma causes disability and death as the resul...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Gabrielli A,Svegliati S,Moroncini G,Pomponio G,Santillo M,Avvedimento EV

    更新日期:2008-07-01 00:00:00

  • "TRP inflammation" relationship in cardiovascular system.

    abstract::Despite considerable advances in the research and treatment, the precise relationship between inflammation and cardiovascular (CV) disease remains incompletely understood. Therefore, understanding the immunoinflammatory processes underlying the initiation, progression, and exacerbation of many cardiovascular diseases ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Numata T,Takahashi K,Inoue R

    更新日期:2016-05-01 00:00:00

  • Type 2 innate lymphoid cells: at the cross-roads in allergic asthma.

    abstract::Allergic asthma is a chronic inflammatory disease of the lower airways that affects millions of people worldwide. Allergic asthma is a T helper 2 cell (Th2)-mediated disease, in which Th2 cytokines interleukin (IL)-4, IL-5, and IL-13 are closely associated with the symptoms. IL-4 is needed by B cells to switch toward ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: van Rijt L,von Richthofen H,van Ree R

    更新日期:2016-07-01 00:00:00

  • Helicobacter pylori infection and gastric carcinogenesis in rodent models.

    abstract::Helicobacter pylori infection is an important factor for gastric carcinogenesis in human. In carcinogen-treated Mongolian gerbils, H. pylori infection enhances stomach carcinogenesis, while infection alone induced severe hyperplasia called heterotopic proliferative glands. A high-salt diet or early acquisition of the ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Tsukamoto T,Toyoda T,Mizoshita T,Tatematsu M

    更新日期:2013-03-01 00:00:00

  • Introduction: mechanisms of tissue injury in autoimmune diseases.

    abstract::This issue of Seminars in Immunopathology is devoted to the most recent developments in our understanding of the mechanisms leading to tissue injury in autoimmune diseases. These include rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, autoimmune liver diseases, inflammatory bowel diseases, autoimm...

    journal_title:Seminars in immunopathology

    pub_type: 社论


    authors: Eilat D

    更新日期:2014-09-01 00:00:00

  • Immunopathogenesis of idiopathic nephrotic syndrome with relapse.

    abstract::Idiopathic change nephrotic syndrome (INS), the most frequent glomerular disease in children and young adults, is characterized by heavy proteinuria and a relapsing remitting course. Although the mechanisms underlying the pathophysiology of proteinuria remain unclear, clinical and experimental observations suggest tha...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Sahali D,Sendeyo K,Mangier M,Audard V,Zhang SY,Lang P,Ollero M,Pawlak A

    更新日期:2014-07-01 00:00:00

  • Cardiovascular risk in patients with rheumatoid arthritis.

    abstract::Substantial epidemiologic data have shown an increased risk of cardiovascular (CV) disease in rheumatoid arthritis (RA) patients. Traditional CV risk factors may partly contribute to CV disease in RA; however, current evidence underlines the important role of inflammation in the pathogenesis of atherosclerosis and amp...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Lauper K,Gabay C

    更新日期:2017-06-01 00:00:00

  • Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.

    abstract::A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine phosphatase (LYP), a critical ne...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审


    authors: Stanford SM,Mustelin TM,Bottini N

    更新日期:2010-06-01 00:00:00