Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia.

abstract：:This issue of Seminars in Immunopathology is devoted to the most recent developments in our understanding of the mechanisms leading to tissue injury in autoimmune diseases. These include rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, autoimmune liver diseases, inflammatory bowel diseases, autoimm...

journal_title：Seminars in immunopathology

authors： Eilat D

更新日期：2014-09-01 00:00:00

abstract：:Autophagy, a catabolic process involved in the sequestration and lysosomal degradation of cytoplasmic contents, is crucial for cellular homeostasis. The current literature supports that autophagy plays diverse roles in the development, maintenance, and progression of tumors. While genetic evidence indicates autophagy ...

journal_title：Seminars in immunopathology

authors： Roy S,Debnath J

更新日期：2010-12-01 00:00:00

abstract：:The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase of phagocytes is a multi-component electron transferase that uses cytoplasmic NADPH to convert molecular oxygen to superoxide anion, consequently delivering reactive oxygen species to the site of invading microorganisms. Together with soluble factors and ...

journal_title：Seminars in immunopathology

authors： Nauseef WM

更新日期：2008-07-01 00:00:00

abstract：:Asthma is a common, complex, multifaceted disease. It comprises multiple phenotypes, which might benefit from treatment with different types of innovative targeted therapies. Refining these phenotypes and understanding their underlying biological structure would help to apply precision medicine approaches. Using diffe...

journal_title：Seminars in immunopathology

authors： Abdel-Aziz MI,Neerincx AH,Vijverberg SJ,Kraneveld AD,Maitland-van der Zee AH

更新日期：2020-02-01 00:00:00

abstract：:Recent advances in DNA sequencing and mass spectrometry technologies have allowed us to collect more data on microbiome and metabolome to assess the influence of the gut microbiota on human health at a whole-systems level. Major advances in metagenomics and metabolomics technologies have shown that the gut microbiota ...

journal_title：Seminars in immunopathology

authors： Aw W,Fukuda S

更新日期：2015-01-01 00:00:00

abstract：:As predicted by the red queen hypothesis, microbial pathogens are probably the major reason for the evolution of the immune system (Paterson et al., Nature 464:275-278, 2010). In general, at the population level, i.e., for most of us, most of the time, the immune response to infection is highly effective. However, the...

journal_title：Seminars in immunopathology

authors： Garside P,Brewer J

更新日期：2010-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and seventh in women, accounting for 7 % of all cancers, and the third cause of cancer-related death worldwide. Nearly 90 to 95 % of all HCC occur in the context of known and often preventable risk factors, such as chronic viral hepatitis, alcohol a...

journal_title：Seminars in immunopathology

authors： Aghemo A,Colombo M

更新日期：2013-01-01 00:00:00

abstract：:Macrophages in lymphoid organs exhibit a wide variety of phenotypes and functions. These cells excel in the removal of apoptotic cells that arise during the generation of immune cells and are thereby essential for the prevention of auto-immune responses. In addition to this macrophages in the secondary lymphoid organs...

journal_title：Seminars in immunopathology

authors： den Haan JM,Martinez-Pomares L

更新日期：2013-09-01 00:00:00

abstract：:Acute inflammation, a physiologic response to protect cells from microbial infection and other noxious stimuli, is automatically terminated by endogenous anti-inflammatory and pro-resolving mediators to restore homeostatic conditions. However, if timely resolution of inflammation is failed, inflammation persists and c...

journal_title：Seminars in immunopathology

authors： Lee HN,Na HK,Surh YJ

更新日期：2013-03-01 00:00:00

abstract：:Checkpoint inhibitors blocking CTLA-4 (ipilimumab) and PD-1 (nivolumab, pembrolizumab) have transfigured our cancer treatment paradigm. However, these drugs can induce immune-related adverse events that share clinical and pathological characteristics with immune-mediated diseases. One of the most severe immune-related...

journal_title：Seminars in immunopathology

authors： Carbonnel F,Soularue E,Coutzac C,Chaput N,Mateus C,Lepage P,Robert C

更新日期：2017-04-01 00:00:00

abstract：:IgA nephropathy (IgAN) is the most common diagnosis amongst primary glomerular diseases in most countries where renal biopsies are regularly performed. Only a fraction of these patients is at high risk of losing glomerular filtration rate (GFR) in particular those with high grade proteinuria, uncontrolled hypertension...

journal_title：Seminars in immunopathology

authors： Floege J,Moura IC,Daha MR

更新日期：2014-07-01 00:00:00

abstract：:Substantial epidemiologic data have shown an increased risk of cardiovascular (CV) disease in rheumatoid arthritis (RA) patients. Traditional CV risk factors may partly contribute to CV disease in RA; however, current evidence underlines the important role of inflammation in the pathogenesis of atherosclerosis and amp...

journal_title：Seminars in immunopathology

authors： Lauper K,Gabay C

更新日期：2017-06-01 00:00:00

abstract：:Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly...

journal_title：Seminars in immunopathology

authors： Sun S,Dong X

更新日期：2016-05-01 00:00:00

abstract：:Intracellular pathogens need to develop sophisticated mechanisms to survive and thrive in the hostile environment within host cells. Unicellular, eukaryotic parasites from the Apicomplexa phylum have become masters of manipulating their host cells, exploiting signaling, and metabolic pathways to hijack host gene expre...

journal_title：Seminars in immunopathology

authors： Villares M,Berthelet J,Weitzman JB

更新日期：2020-04-01 00:00:00

abstract：:Activation and regulation of the cascade systems of the blood (the complement system, the coagulation/contact activation/kallikrein system, and the fibrinolytic system) occurs via activation of zymogen molecules to specific active proteolytic enzymes. Despite the fact that the generated proteases are all present toget...

journal_title：Seminars in immunopathology

authors： Huber-Lang M,Ekdahl KN,Wiegner R,Fromell K,Nilsson B

更新日期：2018-01-01 00:00:00

abstract：:Why and how HIV makes people sick is highly debated. Recent evidence implicates heightened immune activation due to breakdown of the gastrointestinal barrier as a determining factor of lentiviral pathogenesis. HIV-mediated loss of Th17 cells from the gut-associated lymphoid tissue (GALT) impairs mucosal integrity and ...

journal_title：Seminars in immunopathology

authors： Hofer U,Speck RF

更新日期：2009-07-01 00:00:00

abstract：:The incidence of food allergy in developed countries is rising at a rate that cannot be attributed to genetic variation alone. In this review, we discuss the environmental factors that may contribute to the increasing prevalence of potentially fatal anaphylactic responses to food. Decreased exposure to enteric infecti...

journal_title：Seminars in immunopathology

authors： Feehley T,Stefka AT,Cao S,Nagler CR

更新日期：2012-09-01 00:00:00

abstract：:The intestine is normally colonized by a large and diverse commensal microbiota and is occasionally exposed to a variety of potential pathogens. In recent years, there has been substantial progress made in identifying molecular mechanisms that normally serve to protect the intestine from such enteric bacteria and whic...

journal_title：Seminars in immunopathology

authors： Vijay-Kumar M,Aitken JD,Gewirtz AT

更新日期：2008-02-01 00:00:00

abstract：:The observation that embryonic stem cells (ESCs) expressed reduced levels of major histocompatibility (MHC) class I genes, no MHC class II or costimulatory molecules suggested early on that pluripotent stem cells (PSCs) could be "immune-privileged" and were unable to induce immune reactions. However, soon it became ap...

journal_title：Seminars in immunopathology

authors： Kadereit S,Trounson A

更新日期：2011-11-01 00:00:00

abstract：:CD69 is an activation marker on leukocytes. Early studies showed that the CD69+ cells were detected in the lung of patients with asthmatic and eosinophilic pneumonia, suggesting that CD69 might play crucial roles in the pathogenesis of such inflammatory diseases, rather than simply being an activation marker. Intensiv...

journal_title：Seminars in immunopathology

authors： Kimura MY,Koyama-Nasu R,Yagi R,Nakayama T

更新日期：2019-05-01 00:00:00

abstract：:Food allergy is a harmful immune reaction driven by uncontrolled type 2 immune responses. Considerable evidence demonstrates the key roles of mast cells, IgE, and TH2 cytokines in mediating food allergy. However, this evidence provides limited insight into why only some, rather than all, food allergic individuals are ...

journal_title：Seminars in immunopathology

authors： Shik D,Tomar S,Lee JB,Chen CY,Smith A,Wang YH

更新日期：2017-01-01 00:00:00

abstract：:Cystein-rich protein 61 (CYR61/CCN1) is a component of the extracellular matrix, which is produced and secreted by several cell types including endothelial cells, fibroblasts and smooth muscle cells. CCN1 has been implicated in leukocyte migration and the inflammatory process, but it is also involved in cardiovascular...

journal_title：Seminars in immunopathology

authors： Emre Y,Imhof BA

更新日期：2014-03-01 00:00:00

abstract：:In autoinflammatory disorders, dysregulation of the innate immune response leads to an excessive cytokine release. The disease course is often characterized by high morbidity and mortality, treatment is mostly difficult and therapeutic options are limited. In most cases, life-long control of ongoing inflammation is ne...

journal_title：Seminars in immunopathology

authors： Kallinich T

更新日期：2015-07-01 00:00:00

abstract：:Translational research generally refers to a "bench to bedside" approach where basic science discoveries in models move to clinical trials in humans. However, a "bedside to bench to bedside" approach may be more promising with respect to clinical relevance, since it starts with a clinical observation that can serve as...

journal_title：Seminars in immunopathology

authors： Gold SM,Voskuhl RR

更新日期：2016-11-01 00:00:00

abstract：:The mucosal immune system and the microbiota in the intestinal tract have recently been shown to play a key role in the pathogenesis of inflammatory bowel disease (IBD). Both of these can be influenced by food. Thus, we propose dietary intervention as a therapeutic option for IBD. In this review, we discuss the intera...

journal_title：Seminars in immunopathology

authors： Witkowski M,Witkowski M,Gagliani N,Huber S

更新日期：2018-02-01 00:00:00

abstract：:Helicobacter pylori infection is an important factor for gastric carcinogenesis in human. In carcinogen-treated Mongolian gerbils, H. pylori infection enhances stomach carcinogenesis, while infection alone induced severe hyperplasia called heterotopic proliferative glands. A high-salt diet or early acquisition of the ...

journal_title：Seminars in immunopathology

authors： Tsukamoto T,Toyoda T,Mizoshita T,Tatematsu M

更新日期：2013-03-01 00:00:00

abstract：:The recent rise in obesity-related diseases, such as nonalcoholic fatty liver disease and its strong association with microbiota, has elicited interest in the underlying mechanisms of these pathologies. Experimental models have highlighted several mechanisms connecting microbiota to the development of liver dysfunctio...

journal_title：Seminars in immunopathology

authors： Imajo K,Yoneda M,Ogawa Y,Wada K,Nakajima A

更新日期：2014-01-01 00:00:00

abstract：:Systemic sclerosis (SSc, scleroderma) is a devastating, immune-mediated, multisystem disorder characterized by microvasculature damage, circulating autoantibodies, and fibroblast activation, leading to massive fibrosis of skin, vessels, muscles, and visceral organs. Scleroderma causes disability and death as the resul...

journal_title：Seminars in immunopathology

authors： Gabrielli A,Svegliati S,Moroncini G,Pomponio G,Santillo M,Avvedimento EV

更新日期：2008-07-01 00:00:00

abstract：:Microsporidia is a group of pathogens, which can pose severe risks to the immunocompromised population such as HIV-infected individuals. The expertise to diagnose these pathogens is limited and therefore their prevalence is believed to be much higher than what is currently known. In a mouse model of infections, it has...

journal_title：Seminars in immunopathology

authors： Moretto MM,Harrow DI,Khan IA

更新日期：2015-05-01 00:00:00

abstract：:Obesity represents a serious health problem as it is rapidly increasing worldwide. Obesity is associated with reduced healthspan and lifespan, decreased responses to infections and vaccination, and increased frequency of inflammatory conditions typical of old age. Obesity is characterized by increased fat mass and rem...

journal_title：Seminars in immunopathology

authors： Frasca D,Blomberg BB

更新日期：2020-10-01 00:00:00