Abstract:
:Lung transplantation is the only therapeutic option for patients with end-stage pulmonary disorders. Despite the improvements in surgical techniques and immunosuppressive therapy, allograft function and long-term survival are limited by the development of chronic lung transplant rejection. In this review, we focus on bronchiolitis obliterans syndrome (BOS) which is the major manifestation of chronic lung allograft rejection. We specifically review the effect of infection, a risk factor for BOS, cytokines/chemokines in the pathogenesis of BOS, and the potential link between the allograft microbiome and immune responses that may mediate the development of BOS. Understanding the allograft microbiome and how it relates to the pathologic mechanisms of BOS may suggest targeted therapies to improve long-term survival post-lung transplantation.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Nakajima T,Palchevsky V,Perkins DL,Belperio JA,Finn PWdoi
10.1007/s00281-011-0249-9subject
Has Abstractpub_date
2011-03-01 00:00:00pages
135-56issue
2eissn
1863-2297issn
1863-2300journal_volume
33pub_type
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