Abstract：
:Staphylococcus epidermidis is the most important member of the coagulase-negative staphylococci and one of the most abundant colonizers of human skin. While for a long time regarded as innocuous, it has been identified as the most frequent cause of device-related infections occurring in the hospital setting and is therefore now recognized as an important opportunistic pathogen. S. epidermidis produces a series of molecules that provide protection from host defenses. Specifically, many proteins and exopolymers, such as the exopolysaccharide PIA, contribute to biofilm formation and inhibit phagocytosis and the activity of human antimicrobial peptides. Furthermore, recent research has identified a family of pro-inflammatory peptides in S. epidermidis, the phenol-soluble modulins (PSMs), which have multiple functions in immune evasion and biofilm development, and may be cytolytic. However, in accordance with the relatively benign relationship that S. epidermidis has with its host, production of aggressive members of the PSM family is kept at a low level. Interestingly, in contrast to S. aureus with its large arsenal of toxins developed for causing infection in the human host, most if not all "virulence factors" of S. epidermidis appear to have original functions in the commensal lifestyle of this bacterium.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Otto Mdoi
10.1007/s00281-011-0296-2subject
Has Abstractpub_date
2012-03-01 00:00:00pages
201-14issue
2eissn
1863-2297issn
1863-2300journal_volume
34pub_type
杂志文章,评审abstract：:Aspergillus fumigatus is a saprotrophic filamentous fungus and also the most prevalent airborne fungal pathogen of humans. Depending on the host's immune status, the variety of diseases caused by A. fumigatus ranges from allergies in immunocompetent hosts to life-threatening invasive infections in patients with impair...
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journal_title：Seminars in immunopathology
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journal_title：Seminars in immunopathology
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更新日期：2011-07-01 00:00:00
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journal_title：Seminars in immunopathology
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
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更新日期：2008-07-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-03-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
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