Recipe for IBD: can we use food to control inflammatory bowel disease?

abstract：:Immunoglobulin G (IgG) molecules can have two completely opposing activities. They can be very potent pro-inflammatory mediators on the one hand, directing the effector functions of the innate immune system towards infected cells, tumor cells or healthy tissues in the case of autoimmune diseases. On the other hand, a ...

journal_title：Seminars in immunopathology

authors： Böhm S,Schwab I,Lux A,Nimmerjahn F

更新日期：2012-05-01 00:00:00

abstract：:Recent advances in DNA sequencing and mass spectrometry technologies have allowed us to collect more data on microbiome and metabolome to assess the influence of the gut microbiota on human health at a whole-systems level. Major advances in metagenomics and metabolomics technologies have shown that the gut microbiota ...

journal_title：Seminars in immunopathology

authors： Aw W,Fukuda S

更新日期：2015-01-01 00:00:00

abstract：:Substantial epidemiologic data have shown an increased risk of cardiovascular (CV) disease in rheumatoid arthritis (RA) patients. Traditional CV risk factors may partly contribute to CV disease in RA; however, current evidence underlines the important role of inflammation in the pathogenesis of atherosclerosis and amp...

journal_title：Seminars in immunopathology

authors： Lauper K,Gabay C

更新日期：2017-06-01 00:00:00

abstract：:Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cer...

journal_title：Seminars in immunopathology

authors： Dai Y

更新日期：2016-05-01 00:00:00

abstract：:O-fucosylglycans on Notch extracellular domain epidermal growth factor (EGF) repeats are critical in modulating Notch signaling by altering the sensitivity of Notch receptors to activation by Notch ligands. Mice lacking Notch O-fucosylglycans display granulo-monocytic myeloproliferation, hematopoietic stem cell dysfun...

journal_title：Seminars in immunopathology

authors： Zhou L

更新日期：2012-05-01 00:00:00

abstract：:Implanted devices are mainly used to improve impaired function or to replace missing anatomic structures. They are made of synthetic material or devitalized biological structures. In contrast to vital transplants, they are not rejected by the body. However, the host reacts against these foreign bodies, a process which...

journal_title：Seminars in immunopathology

authors： Zimmerli W,Sendi P

更新日期：2011-05-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is an immune-mediated chronic cholestatic liver disease with a slowly progressive course. Without treatment, most patients eventually develop fibrosis and cirrhosis of the liver and may need liver transplantation in the late stage of disease. PBC primarily affects women (female preponde...

journal_title：Seminars in immunopathology

authors： Hohenester S,Oude-Elferink RP,Beuers U

更新日期：2009-09-01 00:00:00

abstract：:Despite considerable advances in the research and treatment, the precise relationship between inflammation and cardiovascular (CV) disease remains incompletely understood. Therefore, understanding the immunoinflammatory processes underlying the initiation, progression, and exacerbation of many cardiovascular diseases ...

journal_title：Seminars in immunopathology

authors： Numata T,Takahashi K,Inoue R

更新日期：2016-05-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically studied for its role in environmental chemical-mediated toxicity and carcinogenicity. In the last 5 years, however, it has become clear that the AhR, presumably activated by endogenous ligand(s), plays an important role in immu...

journal_title：Seminars in immunopathology

authors： Sherr DH,Monti S

更新日期：2013-11-01 00:00:00

abstract：:Recent studies have identified novel lymphocyte subsets named innate lymphoid cells (ILCs) lacking antigen-specific receptors. ILCs are present in a wide variety of epithelial compartments and occupy an intermediate position between acquired immune cells and myeloid cells. ILCs are now classified into three groups: gr...

journal_title：Seminars in immunopathology

authors： Moro K,Koyasu S

更新日期：2015-01-01 00:00:00

abstract：:In autoinflammatory disorders, dysregulation of the innate immune response leads to an excessive cytokine release. The disease course is often characterized by high morbidity and mortality, treatment is mostly difficult and therapeutic options are limited. In most cases, life-long control of ongoing inflammation is ne...

journal_title：Seminars in immunopathology

authors： Kallinich T

更新日期：2015-07-01 00:00:00

abstract：:Omega-3 fatty acids serve as the substrate for the formation of a group of lipid mediators that mediate the resolution of inflammation. The cardiovascular inflammatory response in atherosclerosis and vascular injury is characterized by a failure in the resolution of inflammation, resulting in a chronic inflammatory re...

journal_title：Seminars in immunopathology

authors： Carracedo M,Artiach G,Arnardottir H,Bäck M

更新日期：2019-11-01 00:00:00

abstract：:Immunity is not static but varies with age. The immune system of a newborn infant is not "defective" or "immature." Rather, there are distinct features of innate and adaptive immunity from fetal life to adulthood, which may alter the susceptibility of newborn infants to infections compared to adults. Increased protect...

journal_title：Seminars in immunopathology

authors： Hong M,Bertoletti A

更新日期：2017-11-01 00:00:00

abstract：:Basophils and mast cells have long been known to play critical roles in allergic disease and in immunity against parasitic infection. Accumulated evidence also supports that basophils and mast cells have important roles in immune regulations, host defense against bacteria and viruses, and autoimmune diseases. However,...

journal_title：Seminars in immunopathology

authors： Huang H,Li Y,Liu B

更新日期：2016-09-01 00:00:00

abstract：:Ulcerative colitis designates an idiopathic chronic inflammatory bowel disease leading to bloody diarrhea and inflammatory alterations mostly restricted to the large intestine. Many studies continue to unravel important aspects of its etiopathogenesis, and recent pharmaceutical developments broaden the arsenal of ther...

journal_title：Seminars in immunopathology

authors： Neurath MF,Leppkes M

更新日期：2019-11-01 00:00:00

abstract：:Helicobacter pylori infection is an important factor for gastric carcinogenesis in human. In carcinogen-treated Mongolian gerbils, H. pylori infection enhances stomach carcinogenesis, while infection alone induced severe hyperplasia called heterotopic proliferative glands. A high-salt diet or early acquisition of the ...

journal_title：Seminars in immunopathology

authors： Tsukamoto T,Toyoda T,Mizoshita T,Tatematsu M

更新日期：2013-03-01 00:00:00

abstract：:The observation that embryonic stem cells (ESCs) expressed reduced levels of major histocompatibility (MHC) class I genes, no MHC class II or costimulatory molecules suggested early on that pluripotent stem cells (PSCs) could be "immune-privileged" and were unable to induce immune reactions. However, soon it became ap...

journal_title：Seminars in immunopathology

authors： Kadereit S,Trounson A

更新日期：2011-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and seventh in women, accounting for 7 % of all cancers, and the third cause of cancer-related death worldwide. Nearly 90 to 95 % of all HCC occur in the context of known and often preventable risk factors, such as chronic viral hepatitis, alcohol a...

journal_title：Seminars in immunopathology

authors： Aghemo A,Colombo M

更新日期：2013-01-01 00:00:00

abstract：:Preterm birth, defined as delivery at less than 37 weeks' gestation, increases maternal-fetal morbidity and mortality and places heavy financial and emotional burdens on families and society. Although premature cervical remodeling is a major factor in many preterm deliveries, how and why this occurs is poorly understo...

journal_title：Seminars in immunopathology

authors： Pizzella S,El Helou N,Chubiz J,Wang LV,Tuuli MG,England SK,Stout MJ

更新日期：2020-08-01 00:00:00

abstract：:Allergic asthma is a chronic inflammatory disease of the lower airways that affects millions of people worldwide. Allergic asthma is a T helper 2 cell (Th2)-mediated disease, in which Th2 cytokines interleukin (IL)-4, IL-5, and IL-13 are closely associated with the symptoms. IL-4 is needed by B cells to switch toward ...

journal_title：Seminars in immunopathology

authors： van Rijt L,von Richthofen H,van Ree R

更新日期：2016-07-01 00:00:00

abstract：:The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a...

journal_title：Seminars in immunopathology

authors： Caramori G,Casolari P,Barczyk A,Durham AL,Di Stefano A,Adcock I

更新日期：2016-07-01 00:00:00

abstract：:The contact system is a plasma protease cascade that is initiated by coagulation factor XII activation on cardiovascular cells. The system starts procoagulant and proinflammatory reactions, via the intrinsic pathway of coagulation or the kallikrein-kinin system, respectively. The biochemistry of the contact system in ...

journal_title：Seminars in immunopathology

authors： Renné T

更新日期：2012-01-01 00:00:00

abstract：:Membranous nephropathy (MN) is a non-inflammatory organ-specific autoimmune disease which affects the kidney glomerulus, resulting in the formation of immune deposits on the outer aspect of the glomerular basement membrane, complement-mediated proteinuria, and severe renal failure in 30% of patients. In the last 10 ye...

journal_title：Seminars in immunopathology

authors： Debiec H,Ronco P

更新日期：2014-07-01 00:00:00

abstract：:The defining hallmark of IgA nephropathy (IgAN) is deposition of polymeric IgA1 in the glomerular mesangium accompanied by a mesangial proliferative glomerulonephritis. The mechanisms involved in mesangial polymeric IgA1 deposition and the initiation of inflammatory glomerular injury remain unclear. This lack of a com...

journal_title：Seminars in immunopathology

authors： Barratt J,Smith AC,Molyneux K,Feehally J

更新日期：2007-11-01 00:00:00

abstract：:Commensal microbiota shapes the intestinal immune system by regulating T helper (TH) cell lineage differentiation. For example, Bacteroides fragilis colonization not only optimizes the systemic TH1/TH2 balance, but also can induce regulatory T (Treg) cell differentiation in the gut. In addition, segmented filamentous ...

journal_title：Seminars in immunopathology

authors： Furusawa Y,Obata Y,Hase K

更新日期：2015-01-01 00:00:00

abstract：:Staphylococcus epidermidis is the most important member of the coagulase-negative staphylococci and one of the most abundant colonizers of human skin. While for a long time regarded as innocuous, it has been identified as the most frequent cause of device-related infections occurring in the hospital setting and is the...

journal_title：Seminars in immunopathology

authors： Otto M

更新日期：2012-03-01 00:00:00

abstract：:This issue of Seminars in Immunopathology is devoted to the most recent developments in our understanding of the mechanisms leading to tissue injury in autoimmune diseases. These include rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, autoimmune liver diseases, inflammatory bowel diseases, autoimm...

journal_title：Seminars in immunopathology

authors： Eilat D

更新日期：2014-09-01 00:00:00

abstract：:In asthma and allergy genetics, a trend towards a few main topics developed over the last 2 years. First, a number of studies have been published recently which focus on overlapping and/or very specific phenotypes: within the allergy spectrum but also reaching beyond, looking for common genetic traits shared between d...

journal_title：Seminars in immunopathology

authors： Kabesch M,Tost J

更新日期：2020-02-01 00:00:00

abstract：:Infection by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb) is a major cause of morbidity and mortality worldwide. Slow progress has been made in lessening the impact of tuberculosis (TB) on human health, especially in parts of the world where Mtb is endemic. Due to the complexity of TB disease,...

journal_title：Seminars in immunopathology

authors： Kiran D,Podell BK,Chambers M,Basaraba RJ

更新日期：2016-03-01 00:00:00

abstract：:Cytokines and growth factors are key regulators of immune activation, vascular alteration and excessive production of extracellular matrix which are hallmark events in the pathogenesis of systemic sclerosis (SSc). They modulate cell-cell and cell-matrix interactions. In particular, cytokines play a central role in the...

journal_title：Seminars in immunopathology

authors： Raja J,Denton CP

更新日期：2015-09-01 00:00:00