Abstract：
:Macrophages in lymphoid organs exhibit a wide variety of phenotypes and functions. These cells excel in the removal of apoptotic cells that arise during the generation of immune cells and are thereby essential for the prevention of auto-immune responses. In addition to this macrophages in the secondary lymphoid organs form an important barrier for spreading of infections by phagocytosis of pathogens and the activation of both innate and adaptive immune responses. Thus, the remarkable ability of macrophages to phagocytose and handle a wide range of self and non-self material and to produce immunomediators is effectively exploited within lymphoid organs to regulate immune activation.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
den Haan JM,Martinez-Pomares Ldoi
10.1007/s00281-013-0378-4subject
Has Abstractpub_date
2013-09-01 00:00:00pages
541-52issue
5eissn
1863-2297issn
1863-2300journal_volume
35pub_type
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