Resolution of ulcerative colitis.

abstract：:Cytokines and growth factors are key regulators of immune activation, vascular alteration and excessive production of extracellular matrix which are hallmark events in the pathogenesis of systemic sclerosis (SSc). They modulate cell-cell and cell-matrix interactions. In particular, cytokines play a central role in the...

journal_title：Seminars in immunopathology

authors： Raja J,Denton CP

更新日期：2015-09-01 00:00:00

abstract：:The major histocompatibility complex (MHC) glycoprotein family, also referred to as human leukocyte antigens, present endogenous and exogenous antigens to T lymphocytes for recognition and response. These molecules play a central role in enabling the immune system to distinguish self from non-self, which is the basis ...

journal_title：Seminars in immunopathology

authors： Ryan SO,Cobb BA

更新日期：2012-05-01 00:00:00

abstract：:Crohn's disease (CD) is characterized by chronic inflammation of the gastrointestinal tract and represents one of the main inflammatory bowel disease (IBD) forms. The infiltration of immune cells into the mucosa and uncontrolled production of pro-inflammatory cytokines and other mediators trigger the chronic inflammat...

journal_title：Seminars in immunopathology

authors： Schmitt H,Neufert C,Neurath MF,Atreya R

更新日期：2019-11-01 00:00:00

abstract：:Cystein-rich protein 61 (CYR61/CCN1) is a component of the extracellular matrix, which is produced and secreted by several cell types including endothelial cells, fibroblasts and smooth muscle cells. CCN1 has been implicated in leukocyte migration and the inflammatory process, but it is also involved in cardiovascular...

journal_title：Seminars in immunopathology

authors： Emre Y,Imhof BA

更新日期：2014-03-01 00:00:00

abstract：:Food allergy is a harmful immune reaction driven by uncontrolled type 2 immune responses. Considerable evidence demonstrates the key roles of mast cells, IgE, and TH2 cytokines in mediating food allergy. However, this evidence provides limited insight into why only some, rather than all, food allergic individuals are ...

journal_title：Seminars in immunopathology

authors： Shik D,Tomar S,Lee JB,Chen CY,Smith A,Wang YH

更新日期：2017-01-01 00:00:00

abstract：:Translational research generally refers to a "bench to bedside" approach where basic science discoveries in models move to clinical trials in humans. However, a "bedside to bench to bedside" approach may be more promising with respect to clinical relevance, since it starts with a clinical observation that can serve as...

journal_title：Seminars in immunopathology

authors： Gold SM,Voskuhl RR

更新日期：2016-11-01 00:00:00

abstract：:Stronger adaptive immune responses in females can be observed in different mammals, resulting in better control of infections compared to males. However, this presumably evolutionary difference likely also drives higher incidence of autoimmune diseases observed in humans. Here, we summarize sex differences in the most...

journal_title：Seminars in immunopathology

authors： Gold SM,Willing A,Leypoldt F,Paul F,Friese MA

更新日期：2019-03-01 00:00:00

abstract：:Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are two severe autoimmune bullous diseases of the mucosae and/or skin associated with autoantibodies directed against desmoglein (Dsg) 3 and/or Dsg1. These two desmosomal cadherins, typifying stratified epithelia, are components of cell adhesion complexes called des...

journal_title：Seminars in immunopathology

authors： Di Zenzo G,Amber KT,Sayar BS,Müller EJ,Borradori L

更新日期：2016-01-01 00:00:00

abstract：:Malignant transformation of cells is often associated with changes in classical and non-classical HLA class I antigen, HLA class II antigen as well as NK cell activating ligand (NKCAL) expression. These changes are believed to play a role in the clinical course of the disease since these molecules are critical to the ...

journal_title：Seminars in immunopathology

authors： Campoli M,Ferrone S

更新日期：2011-07-01 00:00:00

abstract：:Microsporidia is a group of pathogens, which can pose severe risks to the immunocompromised population such as HIV-infected individuals. The expertise to diagnose these pathogens is limited and therefore their prevalence is believed to be much higher than what is currently known. In a mouse model of infections, it has...

journal_title：Seminars in immunopathology

authors： Moretto MM,Harrow DI,Khan IA

更新日期：2015-05-01 00:00:00

abstract：:Originally identified as a response to starvation in yeast, autophagy is now understood to fulfill a variety of roles in higher eukaryotes, from the maintenance of cellular homeostasis to the cellular response to stress, starvation, and infection. Although genetics and biochemical studies in yeast have identified many...

journal_title：Seminars in immunopathology

authors： Zirin J,Perrimon N

更新日期：2010-12-01 00:00:00

abstract：:Food allergy is an increasingly prevalent disease of immune dysregulation directed to a small subset of proteins. Shared structural and functional features of allergens, such as glycosylation, lipid-binding and protease activity may provide insight into the mechanisms involved in the induction of primary Th2 immune re...

journal_title：Seminars in immunopathology

authors： Ruiter B,Shreffler WG

更新日期：2012-09-01 00:00:00

abstract：:Macrophages in lymphoid organs exhibit a wide variety of phenotypes and functions. These cells excel in the removal of apoptotic cells that arise during the generation of immune cells and are thereby essential for the prevention of auto-immune responses. In addition to this macrophages in the secondary lymphoid organs...

journal_title：Seminars in immunopathology

authors： den Haan JM,Martinez-Pomares L

更新日期：2013-09-01 00:00:00

abstract：:Substantial epidemiologic data have shown an increased risk of cardiovascular (CV) disease in rheumatoid arthritis (RA) patients. Traditional CV risk factors may partly contribute to CV disease in RA; however, current evidence underlines the important role of inflammation in the pathogenesis of atherosclerosis and amp...

journal_title：Seminars in immunopathology

authors： Lauper K,Gabay C

更新日期：2017-06-01 00:00:00

abstract：:Recent emergence of methicillin-resistant Staphylococcus aureus both within and outside healthcare settings has accelerated the use of once reserved last line antibiotics such as vancomycin. With increased use of antibiotics, there has been a rapid rise in the rate of resistance development to the anti-MRSA drugs. As ...

journal_title：Seminars in immunopathology

authors： Park B,Liu GY

更新日期：2012-03-01 00:00:00

abstract：:Staphylococcus epidermidis is the most important member of the coagulase-negative staphylococci and one of the most abundant colonizers of human skin. While for a long time regarded as innocuous, it has been identified as the most frequent cause of device-related infections occurring in the hospital setting and is the...

journal_title：Seminars in immunopathology

authors： Otto M

更新日期：2012-03-01 00:00:00

abstract：:Immunity is not static but varies with age. The immune system of a newborn infant is not "defective" or "immature." Rather, there are distinct features of innate and adaptive immunity from fetal life to adulthood, which may alter the susceptibility of newborn infants to infections compared to adults. Increased protect...

journal_title：Seminars in immunopathology

authors： Hong M,Bertoletti A

更新日期：2017-11-01 00:00:00

abstract：:IL-9 was initially identified as a T cell growth factor with a potential oncogenic activity. Accordingly, IL-9 drives tumor growth in most hematological cancers. However, the links between IL-9 and cancer progression have been recently revisited following the discovery of TH9 cells. TH9 cells, which have been characte...

journal_title：Seminars in immunopathology

authors： Rivera Vargas T,Humblin E,Végran F,Ghiringhelli F,Apetoh L

更新日期：2017-01-01 00:00:00

abstract：:The incidence of food allergy in developed countries is rising at a rate that cannot be attributed to genetic variation alone. In this review, we discuss the environmental factors that may contribute to the increasing prevalence of potentially fatal anaphylactic responses to food. Decreased exposure to enteric infecti...

journal_title：Seminars in immunopathology

authors： Feehley T,Stefka AT,Cao S,Nagler CR

更新日期：2012-09-01 00:00:00

abstract：:Unfortunately, an error occurred in the following passus of the article. The word "receptor" was missing in the sentence "Because T cells do not express GM-CSF receptor [41], GM-CSF affects non-T cells." ...

journal_title：Seminars in immunopathology

authors： Yasuda K,Takeuchi Y,Hirota K

更新日期：2019-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and seventh in women, accounting for 7 % of all cancers, and the third cause of cancer-related death worldwide. Nearly 90 to 95 % of all HCC occur in the context of known and often preventable risk factors, such as chronic viral hepatitis, alcohol a...

journal_title：Seminars in immunopathology

authors： Aghemo A,Colombo M

更新日期：2013-01-01 00:00:00

abstract：:LIGHT and herpes virus entry mediator (HVEM) comprise a ligand-receptor pair in the tumor necrosis factor superfamily. These molecules play an important role in regulating immunity, particularly in the intestinal mucosa. LIGHT also binds the lymphotoxin beta receptor, and HVEM can act as a ligand for immunoglobulin fa...

journal_title：Seminars in immunopathology

authors： Steinberg MW,Shui JW,Ware CF,Kronenberg M

更新日期：2009-07-01 00:00:00

abstract：:Interleukin-9 is a cytokine classically related to type 2 immune responses whose cellular identity has been recently reevaluated to identify a new specialized T helper subset called Th9 and an innate source referred as innate lymphoid cell type 2. Over the past years, IL-9 has been associated with allergic responses, ...

journal_title：Seminars in immunopathology

authors： Licona-Limón P,Arias-Rojas A,Olguín-Martínez E

更新日期：2017-01-01 00:00:00

abstract：:The defining hallmark of IgA nephropathy (IgAN) is deposition of polymeric IgA1 in the glomerular mesangium accompanied by a mesangial proliferative glomerulonephritis. The mechanisms involved in mesangial polymeric IgA1 deposition and the initiation of inflammatory glomerular injury remain unclear. This lack of a com...

journal_title：Seminars in immunopathology

authors： Barratt J,Smith AC,Molyneux K,Feehally J

更新日期：2007-11-01 00:00:00

abstract：:Lupus erythematosus (LE) is a multifactorial autoimmune disease with clinical manifestations of differing severity. The exact pathomechanisms and interactions resulting in the inflammatory and immunological processes of this heterogeneous disease remain elusive. Approaches in the understanding of the pathomechanisms r...

journal_title：Seminars in immunopathology

authors： Kuhn A,Wenzel J,Bijl M

更新日期：2016-01-01 00:00:00

abstract：:The contact system is a plasma protease cascade that is initiated by coagulation factor XII activation on cardiovascular cells. The system starts procoagulant and proinflammatory reactions, via the intrinsic pathway of coagulation or the kallikrein-kinin system, respectively. The biochemistry of the contact system in ...

journal_title：Seminars in immunopathology

authors： Renné T

更新日期：2012-01-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically studied for its role in environmental chemical-mediated toxicity and carcinogenicity. In the last 5 years, however, it has become clear that the AhR, presumably activated by endogenous ligand(s), plays an important role in immu...

journal_title：Seminars in immunopathology

authors： Sherr DH,Monti S

更新日期：2013-11-01 00:00:00

abstract：:The observation that embryonic stem cells (ESCs) expressed reduced levels of major histocompatibility (MHC) class I genes, no MHC class II or costimulatory molecules suggested early on that pluripotent stem cells (PSCs) could be "immune-privileged" and were unable to induce immune reactions. However, soon it became ap...

journal_title：Seminars in immunopathology

authors： Kadereit S,Trounson A

更新日期：2011-11-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gut. Although the precise cause of IBD remains unknown, the most accepted hypothesis of IBD pathogenesis to date is that an aberrant immune response against the gut microbiota is triggered by environmental factors in a genetically...

journal_title：Seminars in immunopathology

authors： Matsuoka K,Kanai T

更新日期：2015-01-01 00:00:00

abstract：:The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world's population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation...

journal_title：Seminars in immunopathology

authors： Cohen Y,Stern-Ginossar N

更新日期：2014-11-01 00:00:00