Abstract：
:Substantial epidemiologic data have shown an increased risk of cardiovascular (CV) disease in rheumatoid arthritis (RA) patients. Traditional CV risk factors may partly contribute to CV disease in RA; however, current evidence underlines the important role of inflammation in the pathogenesis of atherosclerosis and amplification of CV risk. Interplays between inflammation and lipid metabolism in the development of atherosclerosis have been established by recent scientific advances. Atherosclerosis is currently viewed as an inflammatory disease, and modifications of lipoproteins during inflammation accelerate atherogenesis. The role of inflammation in the increased CV risk in RA has been further demonstrated by the CV protective effect of methotrexate and TNF antagonists, particularly in patients responding to these treatments. The management of CV risk in RA should include the use of effective disease-modifying anti-rheumatic drugs to control disease activity and the treatment of traditional CV risk factors.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Lauper K,Gabay Cdoi
10.1007/s00281-017-0632-2subject
Has Abstractpub_date
2017-06-01 00:00:00pages
447-459issue
4eissn
1863-2297issn
1863-2300pii
10.1007/s00281-017-0632-2journal_volume
39pub_type
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