Abstract：
:CD69 is an activation marker on leukocytes. Early studies showed that the CD69+ cells were detected in the lung of patients with asthmatic and eosinophilic pneumonia, suggesting that CD69 might play crucial roles in the pathogenesis of such inflammatory diseases, rather than simply being an activation marker. Intensive studies using mouse models have since clarified that CD69 is a functional molecule regulating the immune responses. We discovered that Myosin light chain 9, 12a, 12b (Myl9/12) are ligands for CD69 and that platelet-derived Myl9 forms a net-like structure (Myl9 nets) that is strongly detected inside blood vessels in inflamed lung. CD69-expressing activated T cells attached to the Myl9 nets can thereby migrate into the inflamed tissues through a system known as the CD69-Myl9 system. In this review, we summarize the discovery of the CD69-Myl9 system and discuss how this system is important in inflammatory immune responses. In addition, we discuss our recent finding that CD69 controls the exhaustion status of tumor-infiltrating T cells and that the blockade of the CD69 function enhances anti-tumor immunity. Finally, we discuss the possibility of CD69 as a new therapeutic target for patients with intractable inflammatory disorders and tumors.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Kimura MY,Koyama-Nasu R,Yagi R,Nakayama Tdoi
10.1007/s00281-019-00734-7subject
Has Abstractpub_date
2019-05-01 00:00:00pages
349-358issue
3eissn
1863-2297issn
1863-2300pii
10.1007/s00281-019-00734-7journal_volume
41pub_type
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-008-0117-4
更新日期：2008-07-01 00:00:00
abstract：:The mucosal immune system and the microbiota in the intestinal tract have recently been shown to play a key role in the pathogenesis of inflammatory bowel disease (IBD). Both of these can be influenced by food. Thus, we propose dietary intervention as a therapeutic option for IBD. In this review, we discuss the intera...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-017-0658-5
更新日期：2018-02-01 00:00:00
abstract：:Type 1 diabetes (T1D) is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta cells in the pancreatic islets in genetically susceptible subjects. The incidence of T1D has increased manifold in most developed countries after World W...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-017-0665-6
更新日期：2017-11-01 00:00:00
abstract：:As predicted by the red queen hypothesis, microbial pathogens are probably the major reason for the evolution of the immune system (Paterson et al., Nature 464:275-278, 2010). In general, at the population level, i.e., for most of us, most of the time, the immune response to infection is highly effective. However, the...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-010-0215-y
更新日期：2010-09-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-017-0659-4
更新日期：2018-02-01 00:00:00
abstract：:Infection by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb) is a major cause of morbidity and mortality worldwide. Slow progress has been made in lessening the impact of tuberculosis (TB) on human health, especially in parts of the world where Mtb is endemic. Due to the complexity of TB disease,...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0537-x
更新日期：2016-03-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0491-7
更新日期：2015-07-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-020-00800-5
更新日期：2020-08-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-020-00779-z
更新日期：2020-04-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-017-0632-2
更新日期：2017-06-01 00:00:00
abstract：:Food allergy is a harmful immune reaction driven by uncontrolled type 2 immune responses. Considerable evidence demonstrates the key roles of mast cells, IgE, and TH2 cytokines in mediating food allergy. However, this evidence provides limited insight into why only some, rather than all, food allergic individuals are ...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-016-0605-x
更新日期：2017-01-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0526-0
更新日期：2016-05-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-017-0646-9
更新日期：2018-01-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-007-0100-5
更新日期：2008-02-01 00:00:00
abstract：:Aspergillus fumigatus is a saprotrophic filamentous fungus and also the most prevalent airborne fungal pathogen of humans. Depending on the host's immune status, the variety of diseases caused by A. fumigatus ranges from allergies in immunocompetent hosts to life-threatening invasive infections in patients with impair...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-014-0465-1
更新日期：2015-03-01 00:00:00
abstract：:Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell failure is a major component of the pathogenesis of type 2 diabetes. It is now well established that increased numbers of innate immune cells, cytokines, and chemokines have detrimental effects on islets in these chronic conditi...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-019-00745-4
更新日期：2019-07-01 00:00:00
abstract：:Close association between chronic inflammation and cancer has been recently highlighted. Indeed, inflammatory bowel disease (IBD) has been strongly linked with an increased risk of development of colorectal cancer (CRC). Inflammatory cell-produced inflammatory mediators, such as proinflammatory cytokines and inducible...
journal_title：Seminars in immunopathology
pub_type： 杂志文章
doi：10.1007/s00281-012-0343-7
更新日期：2013-03-01 00:00:00
abstract：:Microsporidia is a group of pathogens, which can pose severe risks to the immunocompromised population such as HIV-infected individuals. The expertise to diagnose these pathogens is limited and therefore their prevalence is believed to be much higher than what is currently known. In a mouse model of infections, it has...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0482-8
更新日期：2015-05-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-009-0164-5
更新日期：2009-09-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-011-0275-7
更新日期：2011-05-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 社论
doi：10.1007/s00281-014-0446-4
更新日期：2014-09-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-019-00756-1
更新日期：2019-11-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-014-0463-3
更新日期：2015-03-01 00:00:00
abstract：:The major histocompatibility complex (MHC) glycoprotein family, also referred to as human leukocyte antigens, present endogenous and exogenous antigens to T lymphocytes for recognition and response. These molecules play a central role in enabling the immune system to distinguish self from non-self, which is the basis ...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-012-0309-9
更新日期：2012-05-01 00:00:00
abstract：:Membranous nephropathy (MN) is a non-inflammatory organ-specific autoimmune disease which affects the kidney glomerulus, resulting in the formation of immune deposits on the outer aspect of the glomerular basement membrane, complement-mediated proteinuria, and severe renal failure in 30% of patients. In the last 10 ye...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-014-0423-y
更新日期：2014-07-01 00:00:00
abstract：:The incidence of food allergy in developed countries is rising at a rate that cannot be attributed to genetic variation alone. In this review, we discuss the environmental factors that may contribute to the increasing prevalence of potentially fatal anaphylactic responses to food. Decreased exposure to enteric infecti...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-012-0337-5
更新日期：2012-09-01 00:00:00
abstract：:The recent rise in obesity-related diseases, such as nonalcoholic fatty liver disease and its strong association with microbiota, has elicited interest in the underlying mechanisms of these pathologies. Experimental models have highlighted several mechanisms connecting microbiota to the development of liver dysfunctio...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-013-0404-6
更新日期：2014-01-01 00:00:00
abstract：:Dendritic cells (DCs) lie at the heart of the innate immune system, specialised at recognising danger signals in many forms including foreign material, infection or tissue damage and initiating powerful adaptive immune and inflammatory responses. In barrier sites such as the lung, the instrumental role that DCs play a...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-016-0571-3
更新日期：2016-07-01 00:00:00
abstract：:Staphylococcus epidermidis is the most important member of the coagulase-negative staphylococci and one of the most abundant colonizers of human skin. While for a long time regarded as innocuous, it has been identified as the most frequent cause of device-related infections occurring in the hospital setting and is the...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-011-0296-2
更新日期：2012-03-01 00:00:00
abstract：:O-fucosylglycans on Notch extracellular domain epidermal growth factor (EGF) repeats are critical in modulating Notch signaling by altering the sensitivity of Notch receptors to activation by Notch ligands. Mice lacking Notch O-fucosylglycans display granulo-monocytic myeloproliferation, hematopoietic stem cell dysfun...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-012-0303-2
更新日期：2012-05-01 00:00:00
