Abstract:
:Recent emergence of methicillin-resistant Staphylococcus aureus both within and outside healthcare settings has accelerated the use of once reserved last line antibiotics such as vancomycin. With increased use of antibiotics, there has been a rapid rise in the rate of resistance development to the anti-MRSA drugs. As the antibiotic pipeline becomes strained, alternative strategies are being sought for future treatment of S. aureus. Here, we review several novel anti-staphylococcal strategies that, unlike conventional antibiotics, do not target essential gene products elaborated by the pathogen. The approaches seek instead to weaken the S. aureus defense by neutralizing its virulence factors or boosting host immunity. Other strategies target commensal bacteria that naturally colonize the human host to inhibit S. aureus colonization. Ultimately, the aim is to shift the balance between host defense and pathogen virulence in favor of inhibition of S. aureus pathogenic activities.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Park B,Liu GYdoi
10.1007/s00281-011-0297-1subject
Has Abstractpub_date
2012-03-01 00:00:00pages
299-315issue
2eissn
1863-2297issn
1863-2300journal_volume
34pub_type
杂志文章,评审abstract::Dendritic cells (DCs) operate at the intersection of the innate and adaptive immune systems. DCs can promote or inhibit adaptive immune responses against neuroantigens. While DC intrinsic properties, i.e., their maturation state or the subset they belong to, are important determinants of the outcome of an autoimmune r...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-016-0608-7
更新日期:2017-02-01 00:00:00
abstract::The observation that embryonic stem cells (ESCs) expressed reduced levels of major histocompatibility (MHC) class I genes, no MHC class II or costimulatory molecules suggested early on that pluripotent stem cells (PSCs) could be "immune-privileged" and were unable to induce immune reactions. However, soon it became ap...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-011-0265-9
更新日期:2011-11-01 00:00:00
abstract::Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cer...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0526-0
更新日期:2016-05-01 00:00:00
abstract::Fibrosis is a multicellular wound healing process, where myofibroblasts that express extracellular matrix components extensively cross-talk with other cells resident in the liver or recruited from the bloodstream. Macrophages and infiltrating monocytes participate in the development of fibrosis via several mechanisms,...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-009-0169-0
更新日期:2009-09-01 00:00:00
abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by synaptic dysfunction and accumulation of amyloid-beta (Aβ) peptide, which are responsible for the progressive loss of memory. The mechanisms involved in neuron dysfunction in AD remain poorly understood. Recent evidence implicates th...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-013-0373-9
更新日期:2013-05-01 00:00:00
abstract::Translational research generally refers to a "bench to bedside" approach where basic science discoveries in models move to clinical trials in humans. However, a "bedside to bench to bedside" approach may be more promising with respect to clinical relevance, since it starts with a clinical observation that can serve as...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-016-0584-y
更新日期:2016-11-01 00:00:00
abstract::Immunity is not static but varies with age. The immune system of a newborn infant is not "defective" or "immature." Rather, there are distinct features of innate and adaptive immunity from fetal life to adulthood, which may alter the susceptibility of newborn infants to infections compared to adults. Increased protect...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-017-0641-1
更新日期:2017-11-01 00:00:00
abstract::Human pregnancy is a metabolic and immune challenge for the mother who has to accommodate in her womb a semi-allogeneic fetus whose energy needs increase tremendously with gestation. Recent compelling research has suggested that proper inflammatory changes and oxidative balance are a requisite for successful pregnancy...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-007-0071-6
更新日期:2007-06-01 00:00:00
abstract::A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine phosphatase (LYP), a critical ne...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-010-0201-4
更新日期:2010-06-01 00:00:00
abstract::The conventional perception asserts that immunology is the science of 'discrimination' between self and non-self. This concept is however no longer tenable as effector cells of the adaptive immune system are first conditioned to be tolerant to the body's own antigens, collectively known as self until now. Only then at...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-020-00831-y
更新日期:2021-01-07 00:00:00
abstract::IgA nephropathy (IgAN) is the most common diagnosis amongst primary glomerular diseases in most countries where renal biopsies are regularly performed. Only a fraction of these patients is at high risk of losing glomerular filtration rate (GFR) in particular those with high grade proteinuria, uncontrolled hypertension...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-013-0411-7
更新日期:2014-07-01 00:00:00
abstract::Lupus erythematosus (LE) is a multifactorial autoimmune disease with clinical manifestations of differing severity. The exact pathomechanisms and interactions resulting in the inflammatory and immunological processes of this heterogeneous disease remain elusive. Approaches in the understanding of the pathomechanisms r...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0550-0
更新日期:2016-01-01 00:00:00
abstract::Since life in a terrestrial environment threatens mammals continuously with desiccation, the structural, cellular, biochemical, and regulatory mechanisms that sustain permeability barrier homeostasis have justifiably comprised a major thrust of prior and recent research on epidermal barrier function. Yet, the epidermi...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-007-0060-9
更新日期:2007-04-01 00:00:00
abstract::Membranous nephropathy (MN) is a non-inflammatory organ-specific autoimmune disease which affects the kidney glomerulus, resulting in the formation of immune deposits on the outer aspect of the glomerular basement membrane, complement-mediated proteinuria, and severe renal failure in 30% of patients. In the last 10 ye...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-014-0423-y
更新日期:2014-07-01 00:00:00
abstract::Omega-3 fatty acids serve as the substrate for the formation of a group of lipid mediators that mediate the resolution of inflammation. The cardiovascular inflammatory response in atherosclerosis and vascular injury is characterized by a failure in the resolution of inflammation, resulting in a chronic inflammatory re...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-019-00767-y
更新日期:2019-11-01 00:00:00
abstract::This issue of Seminars in Immunopathology is devoted to the most recent developments in our understanding of the mechanisms leading to tissue injury in autoimmune diseases. These include rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, autoimmune liver diseases, inflammatory bowel diseases, autoimm...
journal_title:Seminars in immunopathology
pub_type: 社论
doi:10.1007/s00281-014-0446-4
更新日期:2014-09-01 00:00:00
abstract::Originally identified as a response to starvation in yeast, autophagy is now understood to fulfill a variety of roles in higher eukaryotes, from the maintenance of cellular homeostasis to the cellular response to stress, starvation, and infection. Although genetics and biochemical studies in yeast have identified many...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-010-0223-y
更新日期:2010-12-01 00:00:00
abstract::CD69 is an activation marker on leukocytes. Early studies showed that the CD69+ cells were detected in the lung of patients with asthmatic and eosinophilic pneumonia, suggesting that CD69 might play crucial roles in the pathogenesis of such inflammatory diseases, rather than simply being an activation marker. Intensiv...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-019-00734-7
更新日期:2019-05-01 00:00:00
abstract::IL-9 was initially identified as a T cell growth factor with a potential oncogenic activity. Accordingly, IL-9 drives tumor growth in most hematological cancers. However, the links between IL-9 and cancer progression have been recently revisited following the discovery of TH9 cells. TH9 cells, which have been characte...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-016-0599-4
更新日期:2017-01-01 00:00:00
abstract::In asthma and allergy genetics, a trend towards a few main topics developed over the last 2 years. First, a number of studies have been published recently which focus on overlapping and/or very specific phenotypes: within the allergy spectrum but also reaching beyond, looking for common genetic traits shared between d...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-019-00777-w
更新日期:2020-02-01 00:00:00
abstract::Preterm birth, defined as delivery at less than 37 weeks' gestation, increases maternal-fetal morbidity and mortality and places heavy financial and emotional burdens on families and society. Although premature cervical remodeling is a major factor in many preterm deliveries, how and why this occurs is poorly understo...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-020-00800-5
更新日期:2020-08-01 00:00:00
abstract::Checkpoint inhibitors blocking CTLA-4 (ipilimumab) and PD-1 (nivolumab, pembrolizumab) have transfigured our cancer treatment paradigm. However, these drugs can induce immune-related adverse events that share clinical and pathological characteristics with immune-mediated diseases. One of the most severe immune-related...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-016-0613-x
更新日期:2017-04-01 00:00:00
abstract::Lung transplantation is the only therapeutic option for patients with end-stage pulmonary disorders. Despite the improvements in surgical techniques and immunosuppressive therapy, allograft function and long-term survival are limited by the development of chronic lung transplant rejection. In this review, we focus on ...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-011-0249-9
更新日期:2011-03-01 00:00:00
abstract::Systemic sclerosis (SSc, scleroderma) is a devastating, immune-mediated, multisystem disorder characterized by microvasculature damage, circulating autoantibodies, and fibroblast activation, leading to massive fibrosis of skin, vessels, muscles, and visceral organs. Scleroderma causes disability and death as the resul...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-008-0125-4
更新日期:2008-07-01 00:00:00
abstract::Microsporidia is a group of pathogens, which can pose severe risks to the immunocompromised population such as HIV-infected individuals. The expertise to diagnose these pathogens is limited and therefore their prevalence is believed to be much higher than what is currently known. In a mouse model of infections, it has...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0482-8
更新日期:2015-05-01 00:00:00
abstract::Malignant transformation of cells is often associated with changes in classical and non-classical HLA class I antigen, HLA class II antigen as well as NK cell activating ligand (NKCAL) expression. These changes are believed to play a role in the clinical course of the disease since these molecules are critical to the ...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-011-0270-z
更新日期:2011-07-01 00:00:00
abstract::Cytokines and growth factors are key regulators of immune activation, vascular alteration and excessive production of extracellular matrix which are hallmark events in the pathogenesis of systemic sclerosis (SSc). They modulate cell-cell and cell-matrix interactions. In particular, cytokines play a central role in the...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0511-7
更新日期:2015-09-01 00:00:00
abstract::Type 1 diabetes (T1D) is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta cells in the pancreatic islets in genetically susceptible subjects. The incidence of T1D has increased manifold in most developed countries after World W...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-017-0665-6
更新日期:2017-11-01 00:00:00
abstract::As predicted by the red queen hypothesis, microbial pathogens are probably the major reason for the evolution of the immune system (Paterson et al., Nature 464:275-278, 2010). In general, at the population level, i.e., for most of us, most of the time, the immune response to infection is highly effective. However, the...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-010-0215-y
更新日期:2010-09-01 00:00:00
abstract::In autoinflammatory disorders, dysregulation of the innate immune response leads to an excessive cytokine release. The disease course is often characterized by high morbidity and mortality, treatment is mostly difficult and therapeutic options are limited. In most cases, life-long control of ongoing inflammation is ne...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0501-9
更新日期:2015-07-01 00:00:00