Abstract:
:Dendritic cells (DCs) lie at the heart of the innate immune system, specialised at recognising danger signals in many forms including foreign material, infection or tissue damage and initiating powerful adaptive immune and inflammatory responses. In barrier sites such as the lung, the instrumental role that DCs play at the interface between the environment and the host places them in a pivotal position in determining the severity of inflammatory disease. The past few years has seen a significant increase in our fundamental understanding of the subsets of DCs involved in pulmonary immunity, as well as the mechanisms by which they are activated and which they may use to coordinate downstream inflammation and pathology. In this review, we will summarise current understanding of the multi-faceted role that DCs play in the induction, maintenance and regulation of lung immunopathology, with an emphasis on allergic pulmonary disease.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Cook PC,MacDonald ASdoi
10.1007/s00281-016-0571-3subject
Has Abstractpub_date
2016-07-01 00:00:00pages
449-60issue
4eissn
1863-2297issn
1863-2300pii
10.1007/s00281-016-0571-3journal_volume
38pub_type
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journal_title:Seminars in immunopathology
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2015-03-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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更新日期:2017-06-01 00:00:00
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journal_title:Seminars in immunopathology
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