Abstract：
:The contact system is a plasma protease cascade that is initiated by coagulation factor XII activation on cardiovascular cells. The system starts procoagulant and proinflammatory reactions, via the intrinsic pathway of coagulation or the kallikrein-kinin system, respectively. The biochemistry of the contact system in vitro is well understood, however, its in vivo functions are just beginning to emerge. Data obtained in genetically engineered mice have revealed an essential function of the contact system for thrombus formation. Severe deficiency in contact system proteases impairs thrombus formation but does not reduce the hemostatic capacity of affected individuals. The system is activated by an inorganic polymer, polyphosphate that is released from activated platelets. Excessive inherited activation of the contact system causes a life-threatening swelling disorder, hereditary angioedema. Activation of the contact system by pathogens contributes to leakage in bacterial infections. Mast-cell-derived heparin triggers contact-system-mediated edema formation with implications for allergic disease states. Here we present an overview about the plasma contact system in occlusive and inflammatory disease and its contribution to health and pathology.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Renné Tdoi
10.1007/s00281-011-0288-2subject
Has Abstractpub_date
2012-01-01 00:00:00pages
31-41issue
1eissn
1863-2297issn
1863-2300journal_volume
34pub_type
杂志文章,评审abstract：:The cryopyrin-associated periodic syndrome (CAPS) is a severity spectrum of rare diseases. CAPS comprises the three conditions previously described as familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disorder (NOMID), also known as chronic infanti...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0491-7
更新日期：2015-07-01 00:00:00
abstract：:The profound alterations in the structure, cellular composition, and function of synovial tissue in rheumatoid arthritis (RA) are the basis for the persistent inflammation and cumulative joint destruction that are hallmarks of this disease. In RA, the synovium develops characteristics of a tertiary lymphoid organ, wit...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-017-0631-3
更新日期：2017-06-01 00:00:00
abstract：:Dendritic cells (DCs) operate at the intersection of the innate and adaptive immune systems. DCs can promote or inhibit adaptive immune responses against neuroantigens. While DC intrinsic properties, i.e., their maturation state or the subset they belong to, are important determinants of the outcome of an autoimmune r...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-016-0608-7
更新日期：2017-02-01 00:00:00
abstract：:Helicobacter pylori infection is an important factor for gastric carcinogenesis in human. In carcinogen-treated Mongolian gerbils, H. pylori infection enhances stomach carcinogenesis, while infection alone induced severe hyperplasia called heterotopic proliferative glands. A high-salt diet or early acquisition of the ...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-012-0357-1
更新日期：2013-03-01 00:00:00
abstract：:Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cer...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0526-0
更新日期：2016-05-01 00:00:00
abstract：:Preterm birth, defined as delivery at less than 37 weeks' gestation, increases maternal-fetal morbidity and mortality and places heavy financial and emotional burdens on families and society. Although premature cervical remodeling is a major factor in many preterm deliveries, how and why this occurs is poorly understo...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-020-00800-5
更新日期：2020-08-01 00:00:00
abstract：:Commensal microbiota shapes the intestinal immune system by regulating T helper (TH) cell lineage differentiation. For example, Bacteroides fragilis colonization not only optimizes the systemic TH1/TH2 balance, but also can induce regulatory T (Treg) cell differentiation in the gut. In addition, segmented filamentous ...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-014-0455-3
更新日期：2015-01-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and seventh in women, accounting for 7 % of all cancers, and the third cause of cancer-related death worldwide. Nearly 90 to 95 % of all HCC occur in the context of known and often preventable risk factors, such as chronic viral hepatitis, alcohol a...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-012-0330-z
更新日期：2013-01-01 00:00:00
abstract：:IgA nephropathy (IgAN) is the most common diagnosis amongst primary glomerular diseases in most countries where renal biopsies are regularly performed. Only a fraction of these patients is at high risk of losing glomerular filtration rate (GFR) in particular those with high grade proteinuria, uncontrolled hypertension...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-013-0411-7
更新日期：2014-07-01 00:00:00
abstract：:Omega-3 fatty acids serve as the substrate for the formation of a group of lipid mediators that mediate the resolution of inflammation. The cardiovascular inflammatory response in atherosclerosis and vascular injury is characterized by a failure in the resolution of inflammation, resulting in a chronic inflammatory re...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-019-00767-y
更新日期：2019-11-01 00:00:00
abstract：:Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0530-4
更新日期：2016-05-01 00:00:00
abstract：:The mucosal immune system and the microbiota in the intestinal tract have recently been shown to play a key role in the pathogenesis of inflammatory bowel disease (IBD). Both of these can be influenced by food. Thus, we propose dietary intervention as a therapeutic option for IBD. In this review, we discuss the intera...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-017-0658-5
更新日期：2018-02-01 00:00:00
abstract：:Immunoglobulin G (IgG) molecules can have two completely opposing activities. They can be very potent pro-inflammatory mediators on the one hand, directing the effector functions of the innate immune system towards infected cells, tumor cells or healthy tissues in the case of autoimmune diseases. On the other hand, a ...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-012-0308-x
更新日期：2012-05-01 00:00:00
abstract：:Why and how HIV makes people sick is highly debated. Recent evidence implicates heightened immune activation due to breakdown of the gastrointestinal barrier as a determining factor of lentiviral pathogenesis. HIV-mediated loss of Th17 cells from the gut-associated lymphoid tissue (GALT) impairs mucosal integrity and ...
journal_title：Seminars in immunopathology
pub_type： 杂志文章
doi：10.1007/s00281-009-0158-3
更新日期：2009-07-01 00:00:00
abstract：:The theoretical physicist and Nobel laureate Richard Feynman outlined in his 1959 lecture, "There's plenty of room at the bottom", the enormous possibility of producing and visualising things at smaller scales. The advent of advanced scanning and transmission electron microscopy and high-resolution microscopy has begu...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-014-0463-3
更新日期：2015-03-01 00:00:00
abstract：:Malignant transformation of cells is often associated with changes in classical and non-classical HLA class I antigen, HLA class II antigen as well as NK cell activating ligand (NKCAL) expression. These changes are believed to play a role in the clinical course of the disease since these molecules are critical to the ...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-011-0270-z
更新日期：2011-07-01 00:00:00
abstract：:Unfortunately, an error occurred in the following passus of the article. The word "receptor" was missing in the sentence "Because T cells do not express GM-CSF receptor [41], GM-CSF affects non-T cells." ...
journal_title：Seminars in immunopathology
pub_type： 已发布勘误
doi：10.1007/s00281-019-00746-3
更新日期：2019-05-01 00:00:00
abstract：:Close association between chronic inflammation and cancer has been recently highlighted. Indeed, inflammatory bowel disease (IBD) has been strongly linked with an increased risk of development of colorectal cancer (CRC). Inflammatory cell-produced inflammatory mediators, such as proinflammatory cytokines and inducible...
journal_title：Seminars in immunopathology
pub_type： 杂志文章
doi：10.1007/s00281-012-0343-7
更新日期：2013-03-01 00:00:00
abstract：:Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are two severe autoimmune bullous diseases of the mucosae and/or skin associated with autoantibodies directed against desmoglein (Dsg) 3 and/or Dsg1. These two desmosomal cadherins, typifying stratified epithelia, are components of cell adhesion complexes called des...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0541-1
更新日期：2016-01-01 00:00:00
abstract：:Recent advances in DNA sequencing and mass spectrometry technologies have allowed us to collect more data on microbiome and metabolome to assess the influence of the gut microbiota on human health at a whole-systems level. Major advances in metagenomics and metabolomics technologies have shown that the gut microbiota ...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-014-0456-2
更新日期：2015-01-01 00:00:00
abstract：:Substantial epidemiologic data have shown an increased risk of cardiovascular (CV) disease in rheumatoid arthritis (RA) patients. Traditional CV risk factors may partly contribute to CV disease in RA; however, current evidence underlines the important role of inflammation in the pathogenesis of atherosclerosis and amp...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-017-0632-2
更新日期：2017-06-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-008-0117-4
更新日期：2008-07-01 00:00:00
abstract：:CD69 is an activation marker on leukocytes. Early studies showed that the CD69+ cells were detected in the lung of patients with asthmatic and eosinophilic pneumonia, suggesting that CD69 might play crucial roles in the pathogenesis of such inflammatory diseases, rather than simply being an activation marker. Intensiv...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-019-00734-7
更新日期：2019-05-01 00:00:00
abstract：:Type 1 diabetes (T1D) is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta cells in the pancreatic islets in genetically susceptible subjects. The incidence of T1D has increased manifold in most developed countries after World W...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-017-0665-6
更新日期：2017-11-01 00:00:00
abstract：:The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world's population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-014-0443-7
更新日期：2014-11-01 00:00:00
abstract：:Crohn's disease (CD) is characterized by chronic inflammation of the gastrointestinal tract and represents one of the main inflammatory bowel disease (IBD) forms. The infiltration of immune cells into the mucosa and uncontrolled production of pro-inflammatory cytokines and other mediators trigger the chronic inflammat...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-019-00756-1
更新日期：2019-11-01 00:00:00
abstract：:Lupus erythematosus (LE) is a multifactorial autoimmune disease with clinical manifestations of differing severity. The exact pathomechanisms and interactions resulting in the inflammatory and immunological processes of this heterogeneous disease remain elusive. Approaches in the understanding of the pathomechanisms r...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0550-0
更新日期：2016-01-01 00:00:00
abstract：:Basophils and mast cells have long been known to play critical roles in allergic disease and in immunity against parasitic infection. Accumulated evidence also supports that basophils and mast cells have important roles in immune regulations, host defense against bacteria and viruses, and autoimmune diseases. However,...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-016-0562-4
更新日期：2016-09-01 00:00:00
abstract：:Acute inflammation, a physiologic response to protect cells from microbial infection and other noxious stimuli, is automatically terminated by endogenous anti-inflammatory and pro-resolving mediators to restore homeostatic conditions. However, if timely resolution of inflammation is failed, inflammation persists and c...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-013-0363-y
更新日期：2013-03-01 00:00:00
abstract：:IL-9 was initially identified as a T cell growth factor with a potential oncogenic activity. Accordingly, IL-9 drives tumor growth in most hematological cancers. However, the links between IL-9 and cancer progression have been recently revisited following the discovery of TH9 cells. TH9 cells, which have been characte...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-016-0599-4
更新日期：2017-01-01 00:00:00
