Abstract:
:Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly understood until recently. The goal of the present review is to summarize our current understanding of the mechanisms of acute as well as chronic itch and classifications of the primary itch populations in relationship to transient receptor potential (Trp) channels, which play pivotal roles in multiple somatosensations. The convergent involvement of Trp channels in diverse itch signaling pathways suggests that Trp channels may serve as promising targets for chronic itch treatments.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Sun S,Dong Xdoi
10.1007/s00281-015-0530-4subject
Has Abstractpub_date
2016-05-01 00:00:00pages
293-307issue
3eissn
1863-2297issn
1863-2300pii
10.1007/s00281-015-0530-4journal_volume
38pub_type
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
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