Abstract:
:LIGHT and herpes virus entry mediator (HVEM) comprise a ligand-receptor pair in the tumor necrosis factor superfamily. These molecules play an important role in regulating immunity, particularly in the intestinal mucosa. LIGHT also binds the lymphotoxin beta receptor, and HVEM can act as a ligand for immunoglobulin family molecules, including B- and T-lymphocyte attenuator, which suppresses immune responses. Complexity in this pivotal system arises from several factors, including the non-monogamous pairing of ligands and receptors, and reverse signaling or the ability of some ligands to serve as receptors. As a result, recognition events in this fascinating network of interacting molecules can have pro- or anti-inflammatory consequences. Despite complexity, experiments we and others are carrying out are establishing rules for understanding when and in what cell types these molecules contribute to intestinal inflammation.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Steinberg MW,Shui JW,Ware CF,Kronenberg Mdoi
10.1007/s00281-009-0157-4subject
Has Abstractpub_date
2009-07-01 00:00:00pages
207-21issue
2eissn
1863-2297issn
1863-2300journal_volume
31pub_type
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
pub_type: 已发布勘误
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-016-0606-9
更新日期:2017-01-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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更新日期:2020-02-01 00:00:00
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pub_type: 杂志文章,评审
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