Synovial cellular and molecular markers in rheumatoid arthritis.

abstract：:Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cer...

journal_title：Seminars in immunopathology

authors： Dai Y

更新日期：2016-05-01 00:00:00

abstract：:Crohn's disease (CD) is characterized by chronic inflammation of the gastrointestinal tract and represents one of the main inflammatory bowel disease (IBD) forms. The infiltration of immune cells into the mucosa and uncontrolled production of pro-inflammatory cytokines and other mediators trigger the chronic inflammat...

journal_title：Seminars in immunopathology

authors： Schmitt H,Neufert C,Neurath MF,Atreya R

更新日期：2019-11-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is an immune-mediated chronic cholestatic liver disease with a slowly progressive course. Without treatment, most patients eventually develop fibrosis and cirrhosis of the liver and may need liver transplantation in the late stage of disease. PBC primarily affects women (female preponde...

journal_title：Seminars in immunopathology

authors： Hohenester S,Oude-Elferink RP,Beuers U

更新日期：2009-09-01 00:00:00

abstract：:Since life in a terrestrial environment threatens mammals continuously with desiccation, the structural, cellular, biochemical, and regulatory mechanisms that sustain permeability barrier homeostasis have justifiably comprised a major thrust of prior and recent research on epidermal barrier function. Yet, the epidermi...

journal_title：Seminars in immunopathology

authors： Elias PM

更新日期：2007-04-01 00:00:00

abstract：:Recent advances in DNA sequencing and mass spectrometry technologies have allowed us to collect more data on microbiome and metabolome to assess the influence of the gut microbiota on human health at a whole-systems level. Major advances in metagenomics and metabolomics technologies have shown that the gut microbiota ...

journal_title：Seminars in immunopathology

authors： Aw W,Fukuda S

更新日期：2015-01-01 00:00:00

abstract：:Lupus erythematosus (LE) is a multifactorial autoimmune disease with clinical manifestations of differing severity. The exact pathomechanisms and interactions resulting in the inflammatory and immunological processes of this heterogeneous disease remain elusive. Approaches in the understanding of the pathomechanisms r...

journal_title：Seminars in immunopathology

authors： Kuhn A,Wenzel J,Bijl M

更新日期：2016-01-01 00:00:00

abstract：:Macrophages in lymphoid organs exhibit a wide variety of phenotypes and functions. These cells excel in the removal of apoptotic cells that arise during the generation of immune cells and are thereby essential for the prevention of auto-immune responses. In addition to this macrophages in the secondary lymphoid organs...

journal_title：Seminars in immunopathology

authors： den Haan JM,Martinez-Pomares L

更新日期：2013-09-01 00:00:00

abstract：:The cryopyrin-associated periodic syndrome (CAPS) is a severity spectrum of rare diseases. CAPS comprises the three conditions previously described as familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disorder (NOMID), also known as chronic infanti...

journal_title：Seminars in immunopathology

authors： Kuemmerle-Deschner JB

更新日期：2015-07-01 00:00:00

abstract：:The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world's population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation...

journal_title：Seminars in immunopathology

authors： Cohen Y,Stern-Ginossar N

更新日期：2014-11-01 00:00:00

abstract：:Preterm birth, defined as delivery at less than 37 weeks' gestation, increases maternal-fetal morbidity and mortality and places heavy financial and emotional burdens on families and society. Although premature cervical remodeling is a major factor in many preterm deliveries, how and why this occurs is poorly understo...

journal_title：Seminars in immunopathology

authors： Pizzella S,El Helou N,Chubiz J,Wang LV,Tuuli MG,England SK,Stout MJ

更新日期：2020-08-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gut. Although the precise cause of IBD remains unknown, the most accepted hypothesis of IBD pathogenesis to date is that an aberrant immune response against the gut microbiota is triggered by environmental factors in a genetically...

journal_title：Seminars in immunopathology

authors： Matsuoka K,Kanai T

更新日期：2015-01-01 00:00:00

abstract：:The central nervous system (CNS) is tightly sealed from the changeable milieu of blood by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB). While the BBB is considered to be localized at the level of the endothelial cells within CNS microvessels, the BCSFB is established by choroid...

journal_title：Seminars in immunopathology

authors： Engelhardt B,Sorokin L

更新日期：2009-11-01 00:00:00

abstract：:Recent emergence of methicillin-resistant Staphylococcus aureus both within and outside healthcare settings has accelerated the use of once reserved last line antibiotics such as vancomycin. With increased use of antibiotics, there has been a rapid rise in the rate of resistance development to the anti-MRSA drugs. As ...

journal_title：Seminars in immunopathology

authors： Park B,Liu GY

更新日期：2012-03-01 00:00:00

abstract：:In autoinflammatory disorders, dysregulation of the innate immune response leads to an excessive cytokine release. The disease course is often characterized by high morbidity and mortality, treatment is mostly difficult and therapeutic options are limited. In most cases, life-long control of ongoing inflammation is ne...

journal_title：Seminars in immunopathology

authors： Kallinich T

更新日期：2015-07-01 00:00:00

abstract：:Membranous nephropathy (MN) is a non-inflammatory organ-specific autoimmune disease which affects the kidney glomerulus, resulting in the formation of immune deposits on the outer aspect of the glomerular basement membrane, complement-mediated proteinuria, and severe renal failure in 30% of patients. In the last 10 ye...

journal_title：Seminars in immunopathology

authors： Debiec H,Ronco P

更新日期：2014-07-01 00:00:00

abstract：:Food allergy is a harmful immune reaction driven by uncontrolled type 2 immune responses. Considerable evidence demonstrates the key roles of mast cells, IgE, and TH2 cytokines in mediating food allergy. However, this evidence provides limited insight into why only some, rather than all, food allergic individuals are ...

journal_title：Seminars in immunopathology

authors： Shik D,Tomar S,Lee JB,Chen CY,Smith A,Wang YH

更新日期：2017-01-01 00:00:00

abstract：:Omega-3 fatty acids serve as the substrate for the formation of a group of lipid mediators that mediate the resolution of inflammation. The cardiovascular inflammatory response in atherosclerosis and vascular injury is characterized by a failure in the resolution of inflammation, resulting in a chronic inflammatory re...

journal_title：Seminars in immunopathology

authors： Carracedo M,Artiach G,Arnardottir H,Bäck M

更新日期：2019-11-01 00:00:00

abstract：:A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine phosphatase (LYP), a critical ne...

journal_title：Seminars in immunopathology

authors： Stanford SM,Mustelin TM,Bottini N

更新日期：2010-06-01 00:00:00

abstract：:Dendritic cells (DCs) lie at the heart of the innate immune system, specialised at recognising danger signals in many forms including foreign material, infection or tissue damage and initiating powerful adaptive immune and inflammatory responses. In barrier sites such as the lung, the instrumental role that DCs play a...

journal_title：Seminars in immunopathology

authors： Cook PC,MacDonald AS

更新日期：2016-07-01 00:00:00

abstract：:Cytokines and growth factors are key regulators of immune activation, vascular alteration and excessive production of extracellular matrix which are hallmark events in the pathogenesis of systemic sclerosis (SSc). They modulate cell-cell and cell-matrix interactions. In particular, cytokines play a central role in the...

journal_title：Seminars in immunopathology

authors： Raja J,Denton CP

更新日期：2015-09-01 00:00:00

abstract：:CD69 is an activation marker on leukocytes. Early studies showed that the CD69+ cells were detected in the lung of patients with asthmatic and eosinophilic pneumonia, suggesting that CD69 might play crucial roles in the pathogenesis of such inflammatory diseases, rather than simply being an activation marker. Intensiv...

journal_title：Seminars in immunopathology

authors： Kimura MY,Koyama-Nasu R,Yagi R,Nakayama T

更新日期：2019-05-01 00:00:00

abstract：:Commensal microbiota shapes the intestinal immune system by regulating T helper (TH) cell lineage differentiation. For example, Bacteroides fragilis colonization not only optimizes the systemic TH1/TH2 balance, but also can induce regulatory T (Treg) cell differentiation in the gut. In addition, segmented filamentous ...

journal_title：Seminars in immunopathology

authors： Furusawa Y,Obata Y,Hase K

更新日期：2015-01-01 00:00:00

abstract：:The conventional perception asserts that immunology is the science of 'discrimination' between self and non-self. This concept is however no longer tenable as effector cells of the adaptive immune system are first conditioned to be tolerant to the body's own antigens, collectively known as self until now. Only then at...

journal_title：Seminars in immunopathology

authors： Geenen V

更新日期：2021-01-07 00:00:00

abstract：:Infection by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb) is a major cause of morbidity and mortality worldwide. Slow progress has been made in lessening the impact of tuberculosis (TB) on human health, especially in parts of the world where Mtb is endemic. Due to the complexity of TB disease,...

journal_title：Seminars in immunopathology

authors： Kiran D,Podell BK,Chambers M,Basaraba RJ

更新日期：2016-03-01 00:00:00

abstract：:The defining hallmark of IgA nephropathy (IgAN) is deposition of polymeric IgA1 in the glomerular mesangium accompanied by a mesangial proliferative glomerulonephritis. The mechanisms involved in mesangial polymeric IgA1 deposition and the initiation of inflammatory glomerular injury remain unclear. This lack of a com...

journal_title：Seminars in immunopathology

authors： Barratt J,Smith AC,Molyneux K,Feehally J

更新日期：2007-11-01 00:00:00

abstract：:The major histocompatibility complex (MHC) glycoprotein family, also referred to as human leukocyte antigens, present endogenous and exogenous antigens to T lymphocytes for recognition and response. These molecules play a central role in enabling the immune system to distinguish self from non-self, which is the basis ...

journal_title：Seminars in immunopathology

authors： Ryan SO,Cobb BA

更新日期：2012-05-01 00:00:00

abstract：:Idiopathic change nephrotic syndrome (INS), the most frequent glomerular disease in children and young adults, is characterized by heavy proteinuria and a relapsing remitting course. Although the mechanisms underlying the pathophysiology of proteinuria remain unclear, clinical and experimental observations suggest tha...

journal_title：Seminars in immunopathology

authors： Sahali D,Sendeyo K,Mangier M,Audard V,Zhang SY,Lang P,Ollero M,Pawlak A

更新日期：2014-07-01 00:00:00

abstract：:Acute inflammation, a physiologic response to protect cells from microbial infection and other noxious stimuli, is automatically terminated by endogenous anti-inflammatory and pro-resolving mediators to restore homeostatic conditions. However, if timely resolution of inflammation is failed, inflammation persists and c...

journal_title：Seminars in immunopathology

authors： Lee HN,Na HK,Surh YJ

更新日期：2013-03-01 00:00:00

abstract：:Immunity is not static but varies with age. The immune system of a newborn infant is not "defective" or "immature." Rather, there are distinct features of innate and adaptive immunity from fetal life to adulthood, which may alter the susceptibility of newborn infants to infections compared to adults. Increased protect...

journal_title：Seminars in immunopathology

authors： Hong M,Bertoletti A

更新日期：2017-11-01 00:00:00

abstract：:The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase of phagocytes is a multi-component electron transferase that uses cytoplasmic NADPH to convert molecular oxygen to superoxide anion, consequently delivering reactive oxygen species to the site of invading microorganisms. Together with soluble factors and ...

journal_title：Seminars in immunopathology

authors： Nauseef WM

更新日期：2008-07-01 00:00:00