Abstract：
:Membranous nephropathy (MN) is a non-inflammatory organ-specific autoimmune disease which affects the kidney glomerulus, resulting in the formation of immune deposits on the outer aspect of the glomerular basement membrane, complement-mediated proteinuria, and severe renal failure in 30% of patients. In the last 10 years, substantial advances have been made in the understanding of the molecular bases of MN, with the identification of several antigens and predisposing genes in children and adults. These ground-breaking findings already have a major impact on diagnosis and monitoring and to some extent on therapies. However, there is evidence that the disease is more complex and involves a variety of antigen-antibody systems and genes involved in immune response, progression, recovery, and protective mechanisms. We herein review these recent findings which open new perspectives of research. Understanding the complex pathogenesis of MN will offer many opportunities for future therapeutic interventions and will hopefully have a major impact on patient care. New insights into the molecular mechanisms of MN may also enlighten the pathogenesis of organ-specific autoimmune diseases.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Debiec H,Ronco Pdoi
10.1007/s00281-014-0423-ysubject
Has Abstractpub_date
2014-07-01 00:00:00pages
381-97issue
4eissn
1863-2297issn
1863-2300journal_volume
36pub_type
杂志文章,评审abstract：:The conventional perception asserts that immunology is the science of 'discrimination' between self and non-self. This concept is however no longer tenable as effector cells of the adaptive immune system are first conditioned to be tolerant to the body's own antigens, collectively known as self until now. Only then at...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-020-00831-y
更新日期：2021-01-07 00:00:00
abstract：:A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine phosphatase (LYP), a critical ne...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-010-0201-4
更新日期：2010-06-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-008-0117-4
更新日期：2008-07-01 00:00:00
abstract：:This issue of Seminars in Immunopathology is devoted to the most recent developments in our understanding of the mechanisms leading to tissue injury in autoimmune diseases. These include rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, autoimmune liver diseases, inflammatory bowel diseases, autoimm...
journal_title：Seminars in immunopathology
pub_type： 社论
doi：10.1007/s00281-014-0446-4
更新日期：2014-09-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0537-x
更新日期：2016-03-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-011-0270-z
更新日期：2011-07-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
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更新日期：2019-03-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-007-0089-9
更新日期：2007-11-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
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更新日期：2018-02-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-016-0556-2
更新日期：2016-07-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0511-7
更新日期：2015-09-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-010-0215-y
更新日期：2010-09-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
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更新日期：2020-08-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1007/s00281-017-0631-3
更新日期：2017-06-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-016-0608-7
更新日期：2017-02-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-014-0456-2
更新日期：2015-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Seminars in immunopathology
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pub_type： 杂志文章,评审
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
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更新日期：2008-02-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
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更新日期：2015-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
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更新日期：2009-09-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2019-11-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-010-0213-0
更新日期：2010-12-01 00:00:00
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pub_type： 杂志文章,评审
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