Abstract:
:The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world's population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation. Identifying the pathways that the virus relies on or subverts is of great interest as they have the potential to provide new therapeutic targets and to reveal novel principles in cell biology. Over the past years, high-throughput analyses have profoundly broadened our understanding of the processes that occur during HCMV infection. In this review, we will discuss these new findings and how they impact our understanding of the biology of HCMV.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Cohen Y,Stern-Ginossar Ndoi
10.1007/s00281-014-0443-7subject
Has Abstractpub_date
2014-11-01 00:00:00pages
651-8issue
6eissn
1863-2297issn
1863-2300journal_volume
36pub_type
杂志文章,评审abstract::Acute inflammation, a physiologic response to protect cells from microbial infection and other noxious stimuli, is automatically terminated by endogenous anti-inflammatory and pro-resolving mediators to restore homeostatic conditions. However, if timely resolution of inflammation is failed, inflammation persists and c...
journal_title:Seminars in immunopathology
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abstract::Systemic sclerosis (SSc, scleroderma) is a devastating, immune-mediated, multisystem disorder characterized by microvasculature damage, circulating autoantibodies, and fibroblast activation, leading to massive fibrosis of skin, vessels, muscles, and visceral organs. Scleroderma causes disability and death as the resul...
journal_title:Seminars in immunopathology
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abstract::Basophils and mast cells have long been known to play critical roles in allergic disease and in immunity against parasitic infection. Accumulated evidence also supports that basophils and mast cells have important roles in immune regulations, host defense against bacteria and viruses, and autoimmune diseases. However,...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0536-y
更新日期:2016-05-01 00:00:00
abstract::Crohn's disease (CD) is characterized by chronic inflammation of the gastrointestinal tract and represents one of the main inflammatory bowel disease (IBD) forms. The infiltration of immune cells into the mucosa and uncontrolled production of pro-inflammatory cytokines and other mediators trigger the chronic inflammat...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-019-00756-1
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0491-7
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abstract::Close association between chronic inflammation and cancer has been recently highlighted. Indeed, inflammatory bowel disease (IBD) has been strongly linked with an increased risk of development of colorectal cancer (CRC). Inflammatory cell-produced inflammatory mediators, such as proinflammatory cytokines and inducible...
journal_title:Seminars in immunopathology
pub_type: 杂志文章
doi:10.1007/s00281-012-0343-7
更新日期:2013-03-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0541-1
更新日期:2016-01-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-012-0357-1
更新日期:2013-03-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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更新日期:2019-11-01 00:00:00
abstract::Why and how HIV makes people sick is highly debated. Recent evidence implicates heightened immune activation due to breakdown of the gastrointestinal barrier as a determining factor of lentiviral pathogenesis. HIV-mediated loss of Th17 cells from the gut-associated lymphoid tissue (GALT) impairs mucosal integrity and ...
journal_title:Seminars in immunopathology
pub_type: 杂志文章
doi:10.1007/s00281-009-0158-3
更新日期:2009-07-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-019-00777-w
更新日期:2020-02-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-009-0164-5
更新日期:2009-09-01 00:00:00
abstract::Staphylococcus epidermidis is the most important member of the coagulase-negative staphylococci and one of the most abundant colonizers of human skin. While for a long time regarded as innocuous, it has been identified as the most frequent cause of device-related infections occurring in the hospital setting and is the...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-011-0296-2
更新日期:2012-03-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-019-00776-x
更新日期:2020-02-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-017-0641-1
更新日期:2017-11-01 00:00:00
abstract::LIGHT and herpes virus entry mediator (HVEM) comprise a ligand-receptor pair in the tumor necrosis factor superfamily. These molecules play an important role in regulating immunity, particularly in the intestinal mucosa. LIGHT also binds the lymphotoxin beta receptor, and HVEM can act as a ligand for immunoglobulin fa...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-009-0157-4
更新日期:2009-07-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-016-0571-3
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0482-8
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-007-0060-9
更新日期:2007-04-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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更新日期:2010-12-01 00:00:00
abstract::The defining hallmark of IgA nephropathy (IgAN) is deposition of polymeric IgA1 in the glomerular mesangium accompanied by a mesangial proliferative glomerulonephritis. The mechanisms involved in mesangial polymeric IgA1 deposition and the initiation of inflammatory glomerular injury remain unclear. This lack of a com...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-007-0089-9
更新日期:2007-11-01 00:00:00
abstract::The central nervous system (CNS) is tightly sealed from the changeable milieu of blood by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB). While the BBB is considered to be localized at the level of the endothelial cells within CNS microvessels, the BCSFB is established by choroid...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-009-0177-0
更新日期:2009-11-01 00:00:00
abstract::Implanted devices are mainly used to improve impaired function or to replace missing anatomic structures. They are made of synthetic material or devitalized biological structures. In contrast to vital transplants, they are not rejected by the body. However, the host reacts against these foreign bodies, a process which...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-011-0275-7
更新日期:2011-05-01 00:00:00
abstract::The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically studied for its role in environmental chemical-mediated toxicity and carcinogenicity. In the last 5 years, however, it has become clear that the AhR, presumably activated by endogenous ligand(s), plays an important role in immu...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-013-0390-8
更新日期:2013-11-01 00:00:00
abstract::Macrophages in lymphoid organs exhibit a wide variety of phenotypes and functions. These cells excel in the removal of apoptotic cells that arise during the generation of immune cells and are thereby essential for the prevention of auto-immune responses. In addition to this macrophages in the secondary lymphoid organs...
journal_title:Seminars in immunopathology
pub_type: 杂志文章
doi:10.1007/s00281-013-0378-4
更新日期:2013-09-01 00:00:00
abstract::The mucosal immune system and the microbiota in the intestinal tract have recently been shown to play a key role in the pathogenesis of inflammatory bowel disease (IBD). Both of these can be influenced by food. Thus, we propose dietary intervention as a therapeutic option for IBD. In this review, we discuss the intera...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-017-0658-5
更新日期:2018-02-01 00:00:00
abstract::Activation and regulation of the cascade systems of the blood (the complement system, the coagulation/contact activation/kallikrein system, and the fibrinolytic system) occurs via activation of zymogen molecules to specific active proteolytic enzymes. Despite the fact that the generated proteases are all present toget...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-017-0646-9
更新日期:2018-01-01 00:00:00