Dendritic cells in central nervous system autoimmunity.

Abstract:

:Dendritic cells (DCs) operate at the intersection of the innate and adaptive immune systems. DCs can promote or inhibit adaptive immune responses against neuroantigens. While DC intrinsic properties, i.e., their maturation state or the subset they belong to, are important determinants of the outcome of an autoimmune reaction, tissue-specific cues might also be relevant for the function of DCs. Thus, a better understanding of the performance of distinct DC subsets in specific anatomical niches, not only in lymphoid tissue but also in non-lymphoid tissues such as the meninges, the choroid plexus, and the inflamed CNS parenchyma, will be instrumental for the design of immune intervention strategies to chronic inflammatory diseases that do not put at risk basic surveillance functions of the immune system in the CNS. Here, we will review modern concepts of DC biology in steady state and during autoimmune neuroinflammation.

journal_name

Semin Immunopathol

authors

Sie C,Korn T

doi

10.1007/s00281-016-0608-7

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

99-111

issue

2

eissn

1863-2297

issn

1863-2300

pii

10.1007/s00281-016-0608-7

journal_volume

39

pub_type

杂志文章,评审
  • Oxidative stress and the pathogenesis of scleroderma: the Murrell's hypothesis revisited.

    abstract::Systemic sclerosis (SSc, scleroderma) is a devastating, immune-mediated, multisystem disorder characterized by microvasculature damage, circulating autoantibodies, and fibroblast activation, leading to massive fibrosis of skin, vessels, muscles, and visceral organs. Scleroderma causes disability and death as the resul...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-008-0125-4

    authors: Gabrielli A,Svegliati S,Moroncini G,Pomponio G,Santillo M,Avvedimento EV

    更新日期:2008-07-01 00:00:00

  • Toward the comprehensive understanding of the gut ecosystem via metabolomics-based integrated omics approach.

    abstract::Recent advances in DNA sequencing and mass spectrometry technologies have allowed us to collect more data on microbiome and metabolome to assess the influence of the gut microbiota on human health at a whole-systems level. Major advances in metagenomics and metabolomics technologies have shown that the gut microbiota ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-014-0456-2

    authors: Aw W,Fukuda S

    更新日期:2015-01-01 00:00:00

  • Pathogenesis of implant-associated infection: the role of the host.

    abstract::Implanted devices are mainly used to improve impaired function or to replace missing anatomic structures. They are made of synthetic material or devitalized biological structures. In contrast to vital transplants, they are not rejected by the body. However, the host reacts against these foreign bodies, a process which...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-011-0275-7

    authors: Zimmerli W,Sendi P

    更新日期:2011-05-01 00:00:00

  • Recent findings in the genetics and epigenetics of asthma and allergy.

    abstract::In asthma and allergy genetics, a trend towards a few main topics developed over the last 2 years. First, a number of studies have been published recently which focus on overlapping and/or very specific phenotypes: within the allergy spectrum but also reaching beyond, looking for common genetic traits shared between d...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-019-00777-w

    authors: Kabesch M,Tost J

    更新日期:2020-02-01 00:00:00

  • Immune response in pemphigus and beyond: progresses and emerging concepts.

    abstract::Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are two severe autoimmune bullous diseases of the mucosae and/or skin associated with autoantibodies directed against desmoglein (Dsg) 3 and/or Dsg1. These two desmosomal cadherins, typifying stratified epithelia, are components of cell adhesion complexes called des...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-015-0541-1

    authors: Di Zenzo G,Amber KT,Sayar BS,Müller EJ,Borradori L

    更新日期:2016-01-01 00:00:00

  • Tolerance and immunity to pathogens in early life: insights from HBV infection.

    abstract::Immunity is not static but varies with age. The immune system of a newborn infant is not "defective" or "immature." Rather, there are distinct features of innate and adaptive immunity from fetal life to adulthood, which may alter the susceptibility of newborn infants to infections compared to adults. Increased protect...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-017-0641-1

    authors: Hong M,Bertoletti A

    更新日期:2017-11-01 00:00:00

  • "TRP inflammation" relationship in cardiovascular system.

    abstract::Despite considerable advances in the research and treatment, the precise relationship between inflammation and cardiovascular (CV) disease remains incompletely understood. Therefore, understanding the immunoinflammatory processes underlying the initiation, progression, and exacerbation of many cardiovascular diseases ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-015-0536-y

    authors: Numata T,Takahashi K,Inoue R

    更新日期:2016-05-01 00:00:00

  • Manipulation of host pathways by human cytomegalovirus: insights from genome-wide studies.

    abstract::The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world's population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-014-0443-7

    authors: Cohen Y,Stern-Ginossar N

    更新日期:2014-11-01 00:00:00

  • Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia.

    abstract::Human pregnancy is a metabolic and immune challenge for the mother who has to accommodate in her womb a semi-allogeneic fetus whose energy needs increase tremendously with gestation. Recent compelling research has suggested that proper inflammatory changes and oxidative balance are a requisite for successful pregnancy...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-007-0071-6

    authors: Rusterholz C,Hahn S,Holzgreve W

    更新日期:2007-06-01 00:00:00

  • The role of sialic acid as a modulator of the anti-inflammatory activity of IgG.

    abstract::Immunoglobulin G (IgG) molecules can have two completely opposing activities. They can be very potent pro-inflammatory mediators on the one hand, directing the effector functions of the innate immune system towards infected cells, tumor cells or healthy tissues in the case of autoimmune diseases. On the other hand, a ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-012-0308-x

    authors: Böhm S,Schwab I,Lux A,Nimmerjahn F

    更新日期:2012-05-01 00:00:00

  • Innate lymphoid cells, possible interaction with microbiota.

    abstract::Recent studies have identified novel lymphocyte subsets named innate lymphoid cells (ILCs) lacking antigen-specific receptors. ILCs are present in a wide variety of epithelial compartments and occupy an intermediate position between acquired immune cells and myeloid cells. ILCs are now classified into three groups: gr...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-014-0470-4

    authors: Moro K,Koyasu S

    更新日期:2015-01-01 00:00:00

  • Helicobacter pylori infection and gastric carcinogenesis in rodent models.

    abstract::Helicobacter pylori infection is an important factor for gastric carcinogenesis in human. In carcinogen-treated Mongolian gerbils, H. pylori infection enhances stomach carcinogenesis, while infection alone induced severe hyperplasia called heterotopic proliferative glands. A high-salt diet or early acquisition of the ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-012-0357-1

    authors: Tsukamoto T,Toyoda T,Mizoshita T,Tatematsu M

    更新日期:2013-03-01 00:00:00

  • The role of the aryl hydrocarbon receptor in normal and malignant B cell development.

    abstract::The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically studied for its role in environmental chemical-mediated toxicity and carcinogenicity. In the last 5 years, however, it has become clear that the AhR, presumably activated by endogenous ligand(s), plays an important role in immu...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-013-0390-8

    authors: Sherr DH,Monti S

    更新日期:2013-11-01 00:00:00

  • Toll like receptor-5: protecting the gut from enteric microbes.

    abstract::The intestine is normally colonized by a large and diverse commensal microbiota and is occasionally exposed to a variety of potential pathogens. In recent years, there has been substantial progress made in identifying molecular mechanisms that normally serve to protect the intestine from such enteric bacteria and whic...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-007-0100-5

    authors: Vijay-Kumar M,Aitken JD,Gewirtz AT

    更新日期:2008-02-01 00:00:00

  • Lupus erythematosus revisited.

    abstract::Lupus erythematosus (LE) is a multifactorial autoimmune disease with clinical manifestations of differing severity. The exact pathomechanisms and interactions resulting in the inflammatory and immunological processes of this heterogeneous disease remain elusive. Approaches in the understanding of the pathomechanisms r...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-015-0550-0

    authors: Kuhn A,Wenzel J,Bijl M

    更新日期:2016-01-01 00:00:00

  • Dietary and metabolic modulators of hepatic immunity.

    abstract::The liver is the central metabolic organ of the organism and is thus constantly exposed to gut-derived dietary and microbial antigens. The liver maintains homoeostatic tolerance to these mostly harmless antigens. However, the liver also functions as a barrier organ to harmful pathogens and is thus permissive to liver ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-017-0659-4

    authors: Carambia A,Herkel J

    更新日期:2018-02-01 00:00:00

  • TRPs and pain.

    abstract::Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cer...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-015-0526-0

    authors: Dai Y

    更新日期:2016-05-01 00:00:00

  • The procoagulant and proinflammatory plasma contact system.

    abstract::The contact system is a plasma protease cascade that is initiated by coagulation factor XII activation on cardiovascular cells. The system starts procoagulant and proinflammatory reactions, via the intrinsic pathway of coagulation or the kallikrein-kinin system, respectively. The biochemistry of the contact system in ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-011-0288-2

    authors: Renné T

    更新日期:2012-01-01 00:00:00

  • Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.

    abstract::A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine phosphatase (LYP), a critical ne...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-010-0201-4

    authors: Stanford SM,Mustelin TM,Bottini N

    更新日期:2010-06-01 00:00:00

  • Islet inflammation in type 2 diabetes.

    abstract::Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell failure is a major component of the pathogenesis of type 2 diabetes. It is now well established that increased numbers of innate immune cells, cytokines, and chemokines have detrimental effects on islets in these chronic conditi...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-019-00745-4

    authors: Böni-Schnetzler M,Meier DT

    更新日期:2019-07-01 00:00:00

  • Drosophila as a model system to study autophagy.

    abstract::Originally identified as a response to starvation in yeast, autophagy is now understood to fulfill a variety of roles in higher eukaryotes, from the maintenance of cellular homeostasis to the cellular response to stress, starvation, and infection. Although genetics and biochemical studies in yeast have identified many...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-010-0223-y

    authors: Zirin J,Perrimon N

    更新日期:2010-12-01 00:00:00

  • The gut microbiota and inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gut. Although the precise cause of IBD remains unknown, the most accepted hypothesis of IBD pathogenesis to date is that an aberrant immune response against the gut microbiota is triggered by environmental factors in a genetically...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-014-0454-4

    authors: Matsuoka K,Kanai T

    更新日期:2015-01-01 00:00:00

  • CAPS--pathogenesis, presentation and treatment of an autoinflammatory disease.

    abstract::The cryopyrin-associated periodic syndrome (CAPS) is a severity spectrum of rare diseases. CAPS comprises the three conditions previously described as familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disorder (NOMID), also known as chronic infanti...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-015-0491-7

    authors: Kuemmerle-Deschner JB

    更新日期:2015-07-01 00:00:00

  • Type 2 innate lymphoid cells: at the cross-roads in allergic asthma.

    abstract::Allergic asthma is a chronic inflammatory disease of the lower airways that affects millions of people worldwide. Allergic asthma is a T helper 2 cell (Th2)-mediated disease, in which Th2 cytokines interleukin (IL)-4, IL-5, and IL-13 are closely associated with the symptoms. IL-4 is needed by B cells to switch toward ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-016-0556-2

    authors: van Rijt L,von Richthofen H,van Ree R

    更新日期:2016-07-01 00:00:00

  • Mononuclear cells in liver fibrosis.

    abstract::Fibrosis is a multicellular wound healing process, where myofibroblasts that express extracellular matrix components extensively cross-talk with other cells resident in the liver or recruited from the bloodstream. Macrophages and infiltrating monocytes participate in the development of fibrosis via several mechanisms,...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-009-0169-0

    authors: Marra F,Aleffi S,Galastri S,Provenzano A

    更新日期:2009-09-01 00:00:00

  • The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction.

    abstract::The central nervous system (CNS) is tightly sealed from the changeable milieu of blood by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB). While the BBB is considered to be localized at the level of the endothelial cells within CNS microvessels, the BCSFB is established by choroid...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-009-0177-0

    authors: Engelhardt B,Sorokin L

    更新日期:2009-11-01 00:00:00

  • Autophagy and tumorigenesis.

    abstract::Autophagy, a catabolic process involved in the sequestration and lysosomal degradation of cytoplasmic contents, is crucial for cellular homeostasis. The current literature supports that autophagy plays diverse roles in the development, maintenance, and progression of tumors. While genetic evidence indicates autophagy ...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-010-0213-0

    authors: Roy S,Debnath J

    更新日期:2010-12-01 00:00:00

  • Cytokines in the immunopathology of systemic sclerosis.

    abstract::Cytokines and growth factors are key regulators of immune activation, vascular alteration and excessive production of extracellular matrix which are hallmark events in the pathogenesis of systemic sclerosis (SSc). They modulate cell-cell and cell-matrix interactions. In particular, cytokines play a central role in the...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-015-0511-7

    authors: Raja J,Denton CP

    更新日期:2015-09-01 00:00:00

  • Resolution of ulcerative colitis.

    abstract::Ulcerative colitis designates an idiopathic chronic inflammatory bowel disease leading to bloody diarrhea and inflammatory alterations mostly restricted to the large intestine. Many studies continue to unravel important aspects of its etiopathogenesis, and recent pharmaceutical developments broaden the arsenal of ther...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-019-00751-6

    authors: Neurath MF,Leppkes M

    更新日期:2019-11-01 00:00:00

  • Immunopathogenesis of idiopathic nephrotic syndrome with relapse.

    abstract::Idiopathic change nephrotic syndrome (INS), the most frequent glomerular disease in children and young adults, is characterized by heavy proteinuria and a relapsing remitting course. Although the mechanisms underlying the pathophysiology of proteinuria remain unclear, clinical and experimental observations suggest tha...

    journal_title:Seminars in immunopathology

    pub_type: 杂志文章,评审

    doi:10.1007/s00281-013-0415-3

    authors: Sahali D,Sendeyo K,Mangier M,Audard V,Zhang SY,Lang P,Ollero M,Pawlak A

    更新日期:2014-07-01 00:00:00