Abstract：
:IL-9 was initially identified as a T cell growth factor with a potential oncogenic activity. Accordingly, IL-9 drives tumor growth in most hematological cancers. However, the links between IL-9 and cancer progression have been recently revisited following the discovery of TH9 cells. TH9 cells, which have been characterized in 2008 as a proinflammatory CD4 T cell subset that promotes protection against parasites and drives tissue inflammation in colitis, actually harbor potent IL-9-dependent anti-cancer properties in solid tumors and especially melanoma. While the molecular mechanisms underlying these observations are still being investigated, TH9 cells were demonstrated to activate both innate and adaptive immune responses, thereby favoring anti-cancer immunity and tumor elimination. Human TH9 cells have also been identified in cancer tissues, but their functions remain elusive. The present review aims to discuss the anti-cancer potential of TH9 cells and their possible clinical relevance for cancer immunotherapy.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Rivera Vargas T,Humblin E,Végran F,Ghiringhelli F,Apetoh Ldoi
10.1007/s00281-016-0599-4subject
Has Abstractpub_date
2017-01-01 00:00:00pages
39-46issue
1eissn
1863-2297issn
1863-2300pii
10.1007/s00281-016-0599-4journal_volume
39pub_type
杂志文章,评审abstract：:Immunity is not static but varies with age. The immune system of a newborn infant is not "defective" or "immature." Rather, there are distinct features of innate and adaptive immunity from fetal life to adulthood, which may alter the susceptibility of newborn infants to infections compared to adults. Increased protect...
journal_title：Seminars in immunopathology
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更新日期：2017-11-01 00:00:00
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journal_title：Seminars in immunopathology
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更新日期：2010-12-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0491-7
更新日期：2015-07-01 00:00:00
abstract：:Dendritic cells (DCs) operate at the intersection of the innate and adaptive immune systems. DCs can promote or inhibit adaptive immune responses against neuroantigens. While DC intrinsic properties, i.e., their maturation state or the subset they belong to, are important determinants of the outcome of an autoimmune r...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-016-0608-7
更新日期：2017-02-01 00:00:00
abstract：:Autophagy, a catabolic process involved in the sequestration and lysosomal degradation of cytoplasmic contents, is crucial for cellular homeostasis. The current literature supports that autophagy plays diverse roles in the development, maintenance, and progression of tumors. While genetic evidence indicates autophagy ...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-010-0213-0
更新日期：2010-12-01 00:00:00
abstract：:Recent advances in DNA sequencing and mass spectrometry technologies have allowed us to collect more data on microbiome and metabolome to assess the influence of the gut microbiota on human health at a whole-systems level. Major advances in metagenomics and metabolomics technologies have shown that the gut microbiota ...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-014-0456-2
更新日期：2015-01-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-017-0632-2
更新日期：2017-06-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0537-x
更新日期：2016-03-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-019-00745-4
更新日期：2019-07-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-016-0584-y
更新日期：2016-11-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-011-0288-2
更新日期：2012-01-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-016-0605-x
更新日期：2017-01-01 00:00:00
abstract：:The defining hallmark of IgA nephropathy (IgAN) is deposition of polymeric IgA1 in the glomerular mesangium accompanied by a mesangial proliferative glomerulonephritis. The mechanisms involved in mesangial polymeric IgA1 deposition and the initiation of inflammatory glomerular injury remain unclear. This lack of a com...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-007-0089-9
更新日期：2007-11-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章
doi：10.1007/s00281-013-0378-4
更新日期：2013-09-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-014-0420-1
更新日期：2014-03-01 00:00:00
abstract：:The observation that embryonic stem cells (ESCs) expressed reduced levels of major histocompatibility (MHC) class I genes, no MHC class II or costimulatory molecules suggested early on that pluripotent stem cells (PSCs) could be "immune-privileged" and were unable to induce immune reactions. However, soon it became ap...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-011-0265-9
更新日期：2011-11-01 00:00:00
abstract：:Acute inflammation, a physiologic response to protect cells from microbial infection and other noxious stimuli, is automatically terminated by endogenous anti-inflammatory and pro-resolving mediators to restore homeostatic conditions. However, if timely resolution of inflammation is failed, inflammation persists and c...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-013-0363-y
更新日期：2013-03-01 00:00:00
abstract：:Malignant transformation of cells is often associated with changes in classical and non-classical HLA class I antigen, HLA class II antigen as well as NK cell activating ligand (NKCAL) expression. These changes are believed to play a role in the clinical course of the disease since these molecules are critical to the ...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-011-0270-z
更新日期：2011-07-01 00:00:00
abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by synaptic dysfunction and accumulation of amyloid-beta (Aβ) peptide, which are responsible for the progressive loss of memory. The mechanisms involved in neuron dysfunction in AD remain poorly understood. Recent evidence implicates th...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-013-0373-9
更新日期：2013-05-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-010-0215-y
更新日期：2010-09-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-017-0631-3
更新日期：2017-06-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-019-00751-6
更新日期：2019-11-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-012-0309-9
更新日期：2012-05-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-011-0297-1
更新日期：2012-03-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0530-4
更新日期：2016-05-01 00:00:00
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journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-019-00734-7
更新日期：2019-05-01 00:00:00
abstract：:Primary biliary cirrhosis (PBC) is an immune-mediated chronic cholestatic liver disease with a slowly progressive course. Without treatment, most patients eventually develop fibrosis and cirrhosis of the liver and may need liver transplantation in the late stage of disease. PBC primarily affects women (female preponde...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-009-0164-5
更新日期：2009-09-01 00:00:00
abstract：:In autoinflammatory disorders, dysregulation of the innate immune response leads to an excessive cytokine release. The disease course is often characterized by high morbidity and mortality, treatment is mostly difficult and therapeutic options are limited. In most cases, life-long control of ongoing inflammation is ne...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-015-0501-9
更新日期：2015-07-01 00:00:00
abstract：:Preterm birth, defined as delivery at less than 37 weeks' gestation, increases maternal-fetal morbidity and mortality and places heavy financial and emotional burdens on families and society. Although premature cervical remodeling is a major factor in many preterm deliveries, how and why this occurs is poorly understo...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-020-00800-5
更新日期：2020-08-01 00:00:00
abstract：:The liver is the central metabolic organ of the organism and is thus constantly exposed to gut-derived dietary and microbial antigens. The liver maintains homoeostatic tolerance to these mostly harmless antigens. However, the liver also functions as a barrier organ to harmful pathogens and is thus permissive to liver ...
journal_title：Seminars in immunopathology
pub_type： 杂志文章,评审
doi：10.1007/s00281-017-0659-4
更新日期：2018-02-01 00:00:00
