Abstract:
:Close association between chronic inflammation and cancer has been recently highlighted. Indeed, inflammatory bowel disease (IBD) has been strongly linked with an increased risk of development of colorectal cancer (CRC). Inflammatory cell-produced inflammatory mediators, such as proinflammatory cytokines and inducible enzymes, contribute to this association. In an inflammatory microenvironment, infiltrating macrophages and mast cells mediate production of these inflammatory mediators to promote growth of tumors in target tissues. In contrast to macrophages, contribution of mast cells to CRC development in inflamed colon is not well understood. This study aimed to determine the role of mast cells in inflammation-associated colorectal carcinogenesis. CRC was induced by administration of the colonic carcinogen, azoxymethane (AOM), and the tumor promoter dextran sodium sulfate (DSS) in male mast cell-deficient WBBF(1)-kit (W/W-v) (W/W(v)) and mast cell-normal WBB6F(1)-+/+(WT) mice. At week 12, the W/W(v) mice had markedly lower inflammation scores in the colon when compared with WT mice. The mRNA levels of colonic proinflammatory cytokines and inducible enzymes were also decreased in W/W(V) mice at weeks 12 and 20, when compared with WT counterparts. Colorectal tumors, including CRC, were identified by histopathological analysis performed 20 weeks thereafter. Importantly, there were less neoplastic and preneoplastic colonic lesions in the W/W(v) mice compared with the WT mice. Thus, for the first time, our study shows that mice lacking mast cells are less susceptible to inflammation-associated colorectal carcinogenesis. Our findings also suggest that mast cells and their selected cytokines could play an important role in inflammation-mediated tumorigenesis through regulation of proinflammatory cytokines and inducible inflammatory enzymes.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Tanaka T,Ishikawa Hdoi
10.1007/s00281-012-0343-7subject
Has Abstractpub_date
2013-03-01 00:00:00pages
245-54issue
2eissn
1863-2297issn
1863-2300journal_volume
35pub_type
杂志文章abstract::Asthma is a common, complex, multifaceted disease. It comprises multiple phenotypes, which might benefit from treatment with different types of innovative targeted therapies. Refining these phenotypes and understanding their underlying biological structure would help to apply precision medicine approaches. Using diffe...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-019-00776-x
更新日期:2020-02-01 00:00:00
abstract::Idiopathic change nephrotic syndrome (INS), the most frequent glomerular disease in children and young adults, is characterized by heavy proteinuria and a relapsing remitting course. Although the mechanisms underlying the pathophysiology of proteinuria remain unclear, clinical and experimental observations suggest tha...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-013-0415-3
更新日期:2014-07-01 00:00:00
abstract::The major histocompatibility complex (MHC) glycoprotein family, also referred to as human leukocyte antigens, present endogenous and exogenous antigens to T lymphocytes for recognition and response. These molecules play a central role in enabling the immune system to distinguish self from non-self, which is the basis ...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-012-0309-9
更新日期:2012-05-01 00:00:00
abstract::The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world's population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-014-0443-7
更新日期:2014-11-01 00:00:00
abstract::The conventional perception asserts that immunology is the science of 'discrimination' between self and non-self. This concept is however no longer tenable as effector cells of the adaptive immune system are first conditioned to be tolerant to the body's own antigens, collectively known as self until now. Only then at...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-020-00831-y
更新日期:2021-01-07 00:00:00
abstract::Interleukin-9 is a cytokine classically related to type 2 immune responses whose cellular identity has been recently reevaluated to identify a new specialized T helper subset called Th9 and an innate source referred as innate lymphoid cell type 2. Over the past years, IL-9 has been associated with allergic responses, ...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-016-0606-9
更新日期:2017-01-01 00:00:00
abstract::Recent studies have identified novel lymphocyte subsets named innate lymphoid cells (ILCs) lacking antigen-specific receptors. ILCs are present in a wide variety of epithelial compartments and occupy an intermediate position between acquired immune cells and myeloid cells. ILCs are now classified into three groups: gr...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-014-0470-4
更新日期:2015-01-01 00:00:00
abstract::Aspergillus fumigatus is a saprotrophic filamentous fungus and also the most prevalent airborne fungal pathogen of humans. Depending on the host's immune status, the variety of diseases caused by A. fumigatus ranges from allergies in immunocompetent hosts to life-threatening invasive infections in patients with impair...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-014-0465-1
更新日期:2015-03-01 00:00:00
abstract::The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically studied for its role in environmental chemical-mediated toxicity and carcinogenicity. In the last 5 years, however, it has become clear that the AhR, presumably activated by endogenous ligand(s), plays an important role in immu...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-013-0390-8
更新日期:2013-11-01 00:00:00
abstract::The observation that embryonic stem cells (ESCs) expressed reduced levels of major histocompatibility (MHC) class I genes, no MHC class II or costimulatory molecules suggested early on that pluripotent stem cells (PSCs) could be "immune-privileged" and were unable to induce immune reactions. However, soon it became ap...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-011-0265-9
更新日期:2011-11-01 00:00:00
abstract::Staphylococcus epidermidis is the most important member of the coagulase-negative staphylococci and one of the most abundant colonizers of human skin. While for a long time regarded as innocuous, it has been identified as the most frequent cause of device-related infections occurring in the hospital setting and is the...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-011-0296-2
更新日期:2012-03-01 00:00:00
abstract::Primary biliary cirrhosis (PBC) is an immune-mediated chronic cholestatic liver disease with a slowly progressive course. Without treatment, most patients eventually develop fibrosis and cirrhosis of the liver and may need liver transplantation in the late stage of disease. PBC primarily affects women (female preponde...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-009-0164-5
更新日期:2009-09-01 00:00:00
abstract::The defining hallmark of IgA nephropathy (IgAN) is deposition of polymeric IgA1 in the glomerular mesangium accompanied by a mesangial proliferative glomerulonephritis. The mechanisms involved in mesangial polymeric IgA1 deposition and the initiation of inflammatory glomerular injury remain unclear. This lack of a com...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-007-0089-9
更新日期:2007-11-01 00:00:00
abstract::The intestine is normally colonized by a large and diverse commensal microbiota and is occasionally exposed to a variety of potential pathogens. In recent years, there has been substantial progress made in identifying molecular mechanisms that normally serve to protect the intestine from such enteric bacteria and whic...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-007-0100-5
更新日期:2008-02-01 00:00:00
abstract::Intracellular pathogens need to develop sophisticated mechanisms to survive and thrive in the hostile environment within host cells. Unicellular, eukaryotic parasites from the Apicomplexa phylum have become masters of manipulating their host cells, exploiting signaling, and metabolic pathways to hijack host gene expre...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-020-00779-z
更新日期:2020-04-01 00:00:00
abstract::Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cer...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0526-0
更新日期:2016-05-01 00:00:00
abstract::Dendritic cells (DCs) operate at the intersection of the innate and adaptive immune systems. DCs can promote or inhibit adaptive immune responses against neuroantigens. While DC intrinsic properties, i.e., their maturation state or the subset they belong to, are important determinants of the outcome of an autoimmune r...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-016-0608-7
更新日期:2017-02-01 00:00:00
abstract::Infection by the intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb) is a major cause of morbidity and mortality worldwide. Slow progress has been made in lessening the impact of tuberculosis (TB) on human health, especially in parts of the world where Mtb is endemic. Due to the complexity of TB disease,...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0537-x
更新日期:2016-03-01 00:00:00
abstract::Crohn's disease (CD) is characterized by chronic inflammation of the gastrointestinal tract and represents one of the main inflammatory bowel disease (IBD) forms. The infiltration of immune cells into the mucosa and uncontrolled production of pro-inflammatory cytokines and other mediators trigger the chronic inflammat...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-019-00756-1
更新日期:2019-11-01 00:00:00
abstract::Since life in a terrestrial environment threatens mammals continuously with desiccation, the structural, cellular, biochemical, and regulatory mechanisms that sustain permeability barrier homeostasis have justifiably comprised a major thrust of prior and recent research on epidermal barrier function. Yet, the epidermi...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-007-0060-9
更新日期:2007-04-01 00:00:00
abstract::Food allergy is an increasingly prevalent disease of immune dysregulation directed to a small subset of proteins. Shared structural and functional features of allergens, such as glycosylation, lipid-binding and protease activity may provide insight into the mechanisms involved in the induction of primary Th2 immune re...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-012-0334-8
更新日期:2012-09-01 00:00:00
abstract::Fibrosis is a multicellular wound healing process, where myofibroblasts that express extracellular matrix components extensively cross-talk with other cells resident in the liver or recruited from the bloodstream. Macrophages and infiltrating monocytes participate in the development of fibrosis via several mechanisms,...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-009-0169-0
更新日期:2009-09-01 00:00:00
abstract::Dendritic cells (DCs) lie at the heart of the innate immune system, specialised at recognising danger signals in many forms including foreign material, infection or tissue damage and initiating powerful adaptive immune and inflammatory responses. In barrier sites such as the lung, the instrumental role that DCs play a...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-016-0571-3
更新日期:2016-07-01 00:00:00
abstract::Despite considerable advances in the research and treatment, the precise relationship between inflammation and cardiovascular (CV) disease remains incompletely understood. Therefore, understanding the immunoinflammatory processes underlying the initiation, progression, and exacerbation of many cardiovascular diseases ...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0536-y
更新日期:2016-05-01 00:00:00
abstract::In asthma and allergy genetics, a trend towards a few main topics developed over the last 2 years. First, a number of studies have been published recently which focus on overlapping and/or very specific phenotypes: within the allergy spectrum but also reaching beyond, looking for common genetic traits shared between d...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-019-00777-w
更新日期:2020-02-01 00:00:00
abstract::Obesity represents a serious health problem as it is rapidly increasing worldwide. Obesity is associated with reduced healthspan and lifespan, decreased responses to infections and vaccination, and increased frequency of inflammatory conditions typical of old age. Obesity is characterized by increased fat mass and rem...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-020-00812-1
更新日期:2020-10-01 00:00:00
abstract::The contact system is a plasma protease cascade that is initiated by coagulation factor XII activation on cardiovascular cells. The system starts procoagulant and proinflammatory reactions, via the intrinsic pathway of coagulation or the kallikrein-kinin system, respectively. The biochemistry of the contact system in ...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-011-0288-2
更新日期:2012-01-01 00:00:00
abstract::Membranous nephropathy (MN) is a non-inflammatory organ-specific autoimmune disease which affects the kidney glomerulus, resulting in the formation of immune deposits on the outer aspect of the glomerular basement membrane, complement-mediated proteinuria, and severe renal failure in 30% of patients. In the last 10 ye...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-014-0423-y
更新日期:2014-07-01 00:00:00
abstract::This issue of Seminars in Immunopathology is devoted to the most recent developments in our understanding of the mechanisms leading to tissue injury in autoimmune diseases. These include rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, autoimmune liver diseases, inflammatory bowel diseases, autoimm...
journal_title:Seminars in immunopathology
pub_type: 社论
doi:10.1007/s00281-014-0446-4
更新日期:2014-09-01 00:00:00
abstract::Substantial epidemiologic data have shown an increased risk of cardiovascular (CV) disease in rheumatoid arthritis (RA) patients. Traditional CV risk factors may partly contribute to CV disease in RA; however, current evidence underlines the important role of inflammation in the pathogenesis of atherosclerosis and amp...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-017-0632-2
更新日期:2017-06-01 00:00:00