Transcriptional regulation of mast cell and basophil lineage commitment.

abstract：:Ulcerative colitis designates an idiopathic chronic inflammatory bowel disease leading to bloody diarrhea and inflammatory alterations mostly restricted to the large intestine. Many studies continue to unravel important aspects of its etiopathogenesis, and recent pharmaceutical developments broaden the arsenal of ther...

journal_title：Seminars in immunopathology

authors： Neurath MF,Leppkes M

更新日期：2019-11-01 00:00:00

abstract：:Since life in a terrestrial environment threatens mammals continuously with desiccation, the structural, cellular, biochemical, and regulatory mechanisms that sustain permeability barrier homeostasis have justifiably comprised a major thrust of prior and recent research on epidermal barrier function. Yet, the epidermi...

journal_title：Seminars in immunopathology

authors： Elias PM

更新日期：2007-04-01 00:00:00

abstract：:Idiopathic change nephrotic syndrome (INS), the most frequent glomerular disease in children and young adults, is characterized by heavy proteinuria and a relapsing remitting course. Although the mechanisms underlying the pathophysiology of proteinuria remain unclear, clinical and experimental observations suggest tha...

journal_title：Seminars in immunopathology

authors： Sahali D,Sendeyo K,Mangier M,Audard V,Zhang SY,Lang P,Ollero M,Pawlak A

更新日期：2014-07-01 00:00:00

abstract：:Lupus erythematosus (LE) is a multifactorial autoimmune disease with clinical manifestations of differing severity. The exact pathomechanisms and interactions resulting in the inflammatory and immunological processes of this heterogeneous disease remain elusive. Approaches in the understanding of the pathomechanisms r...

journal_title：Seminars in immunopathology

authors： Kuhn A,Wenzel J,Bijl M

更新日期：2016-01-01 00:00:00

abstract：:The liver is the central metabolic organ of the organism and is thus constantly exposed to gut-derived dietary and microbial antigens. The liver maintains homoeostatic tolerance to these mostly harmless antigens. However, the liver also functions as a barrier organ to harmful pathogens and is thus permissive to liver ...

journal_title：Seminars in immunopathology

authors： Carambia A,Herkel J

更新日期：2018-02-01 00:00:00

abstract：:The profound alterations in the structure, cellular composition, and function of synovial tissue in rheumatoid arthritis (RA) are the basis for the persistent inflammation and cumulative joint destruction that are hallmarks of this disease. In RA, the synovium develops characteristics of a tertiary lymphoid organ, wit...

journal_title：Seminars in immunopathology

authors： Asif Amin M,Fox DA,Ruth JH

更新日期：2017-06-01 00:00:00

abstract：:Crohn's disease (CD) is characterized by chronic inflammation of the gastrointestinal tract and represents one of the main inflammatory bowel disease (IBD) forms. The infiltration of immune cells into the mucosa and uncontrolled production of pro-inflammatory cytokines and other mediators trigger the chronic inflammat...

journal_title：Seminars in immunopathology

authors： Schmitt H,Neufert C,Neurath MF,Atreya R

更新日期：2019-11-01 00:00:00

abstract：:Type 1 diabetes (T1D) is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta cells in the pancreatic islets in genetically susceptible subjects. The incidence of T1D has increased manifold in most developed countries after World W...

journal_title：Seminars in immunopathology

authors： Knip M,Luopajärvi K,Härkönen T

更新日期：2017-11-01 00:00:00

abstract：:Omega-3 fatty acids serve as the substrate for the formation of a group of lipid mediators that mediate the resolution of inflammation. The cardiovascular inflammatory response in atherosclerosis and vascular injury is characterized by a failure in the resolution of inflammation, resulting in a chronic inflammatory re...

journal_title：Seminars in immunopathology

authors： Carracedo M,Artiach G,Arnardottir H,Bäck M

更新日期：2019-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and seventh in women, accounting for 7 % of all cancers, and the third cause of cancer-related death worldwide. Nearly 90 to 95 % of all HCC occur in the context of known and often preventable risk factors, such as chronic viral hepatitis, alcohol a...

journal_title：Seminars in immunopathology

authors： Aghemo A,Colombo M

更新日期：2013-01-01 00:00:00

abstract：:Translational research generally refers to a "bench to bedside" approach where basic science discoveries in models move to clinical trials in humans. However, a "bedside to bench to bedside" approach may be more promising with respect to clinical relevance, since it starts with a clinical observation that can serve as...

journal_title：Seminars in immunopathology

authors： Gold SM,Voskuhl RR

更新日期：2016-11-01 00:00:00

abstract：:The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette smoking. In the last quarter of the century, the analysis of specimens obtained from the lower airways of COPD patients compared with those from a...

journal_title：Seminars in immunopathology

authors： Caramori G,Casolari P,Barczyk A,Durham AL,Di Stefano A,Adcock I

更新日期：2016-07-01 00:00:00

abstract：:The intestine is normally colonized by a large and diverse commensal microbiota and is occasionally exposed to a variety of potential pathogens. In recent years, there has been substantial progress made in identifying molecular mechanisms that normally serve to protect the intestine from such enteric bacteria and whic...

journal_title：Seminars in immunopathology

authors： Vijay-Kumar M,Aitken JD,Gewirtz AT

更新日期：2008-02-01 00:00:00

abstract：:Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly...

journal_title：Seminars in immunopathology

authors： Sun S,Dong X

更新日期：2016-05-01 00:00:00

abstract：:The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world's population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation...

journal_title：Seminars in immunopathology

authors： Cohen Y,Stern-Ginossar N

更新日期：2014-11-01 00:00:00

abstract：:CD69 is an activation marker on leukocytes. Early studies showed that the CD69+ cells were detected in the lung of patients with asthmatic and eosinophilic pneumonia, suggesting that CD69 might play crucial roles in the pathogenesis of such inflammatory diseases, rather than simply being an activation marker. Intensiv...

journal_title：Seminars in immunopathology

authors： Kimura MY,Koyama-Nasu R,Yagi R,Nakayama T

更新日期：2019-05-01 00:00:00

abstract：:Immunoglobulin G (IgG) molecules can have two completely opposing activities. They can be very potent pro-inflammatory mediators on the one hand, directing the effector functions of the innate immune system towards infected cells, tumor cells or healthy tissues in the case of autoimmune diseases. On the other hand, a ...

journal_title：Seminars in immunopathology

authors： Böhm S,Schwab I,Lux A,Nimmerjahn F

更新日期：2012-05-01 00:00:00

abstract：:This issue of Seminars in Immunopathology is devoted to the most recent developments in our understanding of the mechanisms leading to tissue injury in autoimmune diseases. These include rheumatoid arthritis, systemic lupus erythematosus, type I diabetes, autoimmune liver diseases, inflammatory bowel diseases, autoimm...

journal_title：Seminars in immunopathology

authors： Eilat D

更新日期：2014-09-01 00:00:00

abstract：:Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cer...

journal_title：Seminars in immunopathology

authors： Dai Y

更新日期：2016-05-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically studied for its role in environmental chemical-mediated toxicity and carcinogenicity. In the last 5 years, however, it has become clear that the AhR, presumably activated by endogenous ligand(s), plays an important role in immu...

journal_title：Seminars in immunopathology

authors： Sherr DH,Monti S

更新日期：2013-11-01 00:00:00

abstract：:IL-9 was initially identified as a T cell growth factor with a potential oncogenic activity. Accordingly, IL-9 drives tumor growth in most hematological cancers. However, the links between IL-9 and cancer progression have been recently revisited following the discovery of TH9 cells. TH9 cells, which have been characte...

journal_title：Seminars in immunopathology

authors： Rivera Vargas T,Humblin E,Végran F,Ghiringhelli F,Apetoh L

更新日期：2017-01-01 00:00:00

abstract：:Human pregnancy is a metabolic and immune challenge for the mother who has to accommodate in her womb a semi-allogeneic fetus whose energy needs increase tremendously with gestation. Recent compelling research has suggested that proper inflammatory changes and oxidative balance are a requisite for successful pregnancy...

journal_title：Seminars in immunopathology

authors： Rusterholz C,Hahn S,Holzgreve W

更新日期：2007-06-01 00:00:00

abstract：:The mucosal immune system and the microbiota in the intestinal tract have recently been shown to play a key role in the pathogenesis of inflammatory bowel disease (IBD). Both of these can be influenced by food. Thus, we propose dietary intervention as a therapeutic option for IBD. In this review, we discuss the intera...

journal_title：Seminars in immunopathology

authors： Witkowski M,Witkowski M,Gagliani N,Huber S

更新日期：2018-02-01 00:00:00

abstract：:The defining hallmark of IgA nephropathy (IgAN) is deposition of polymeric IgA1 in the glomerular mesangium accompanied by a mesangial proliferative glomerulonephritis. The mechanisms involved in mesangial polymeric IgA1 deposition and the initiation of inflammatory glomerular injury remain unclear. This lack of a com...

journal_title：Seminars in immunopathology

authors： Barratt J,Smith AC,Molyneux K,Feehally J

更新日期：2007-11-01 00:00:00

abstract：:Recent emergence of methicillin-resistant Staphylococcus aureus both within and outside healthcare settings has accelerated the use of once reserved last line antibiotics such as vancomycin. With increased use of antibiotics, there has been a rapid rise in the rate of resistance development to the anti-MRSA drugs. As ...

journal_title：Seminars in immunopathology

authors： Park B,Liu GY

更新日期：2012-03-01 00:00:00

abstract：:Macrophages in lymphoid organs exhibit a wide variety of phenotypes and functions. These cells excel in the removal of apoptotic cells that arise during the generation of immune cells and are thereby essential for the prevention of auto-immune responses. In addition to this macrophages in the secondary lymphoid organs...

journal_title：Seminars in immunopathology

authors： den Haan JM,Martinez-Pomares L

更新日期：2013-09-01 00:00:00

abstract：:In autoinflammatory disorders, dysregulation of the innate immune response leads to an excessive cytokine release. The disease course is often characterized by high morbidity and mortality, treatment is mostly difficult and therapeutic options are limited. In most cases, life-long control of ongoing inflammation is ne...

journal_title：Seminars in immunopathology

authors： Kallinich T

更新日期：2015-07-01 00:00:00

abstract：:Helicobacter pylori infection is an important factor for gastric carcinogenesis in human. In carcinogen-treated Mongolian gerbils, H. pylori infection enhances stomach carcinogenesis, while infection alone induced severe hyperplasia called heterotopic proliferative glands. A high-salt diet or early acquisition of the ...

journal_title：Seminars in immunopathology

authors： Tsukamoto T,Toyoda T,Mizoshita T,Tatematsu M

更新日期：2013-03-01 00:00:00

abstract：:Recent studies have identified novel lymphocyte subsets named innate lymphoid cells (ILCs) lacking antigen-specific receptors. ILCs are present in a wide variety of epithelial compartments and occupy an intermediate position between acquired immune cells and myeloid cells. ILCs are now classified into three groups: gr...

journal_title：Seminars in immunopathology

authors： Moro K,Koyasu S

更新日期：2015-01-01 00:00:00

abstract：:A relatively large number of protein tyrosine phosphatases (PTPs) are known to regulate signaling through the T cell receptor (TCR). Recent human genetics studies have shown that several of these PTPs are encoded by major autoimmunity genes. Here, we will focus on the lymphoid tyrosine phosphatase (LYP), a critical ne...

journal_title：Seminars in immunopathology

authors： Stanford SM,Mustelin TM,Bottini N

更新日期：2010-06-01 00:00:00