Abstract:
:The intestine is normally colonized by a large and diverse commensal microbiota and is occasionally exposed to a variety of potential pathogens. In recent years, there has been substantial progress made in identifying molecular mechanisms that normally serve to protect the intestine from such enteric bacteria and which may go awry in chronic idiopathic inflammatory diseases of the gut. One specific molecular interaction that appears to play a key role in governing bacterial-intestinal interactions is that of the bacterial protein flagellin with toll-like receptor 5. This article reviews studies performed in vitro, in mice, and in humans that indicate an important role for the flagellin-TLR5 interaction in regulating both the innate and adaptive immune responses in the intestine.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Vijay-Kumar M,Aitken JD,Gewirtz ATdoi
10.1007/s00281-007-0100-5subject
Has Abstractpub_date
2008-02-01 00:00:00pages
11-21issue
1eissn
1863-2297issn
1863-2300journal_volume
30pub_type
杂志文章,评审abstract::Hepatocellular carcinoma (HCC) is the fifth most common cancer in men and seventh in women, accounting for 7 % of all cancers, and the third cause of cancer-related death worldwide. Nearly 90 to 95 % of all HCC occur in the context of known and often preventable risk factors, such as chronic viral hepatitis, alcohol a...
journal_title:Seminars in immunopathology
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doi:10.1007/s00281-012-0330-z
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abstract::Lupus erythematosus (LE) is a multifactorial autoimmune disease with clinical manifestations of differing severity. The exact pathomechanisms and interactions resulting in the inflammatory and immunological processes of this heterogeneous disease remain elusive. Approaches in the understanding of the pathomechanisms r...
journal_title:Seminars in immunopathology
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abstract::Originally identified as a response to starvation in yeast, autophagy is now understood to fulfill a variety of roles in higher eukaryotes, from the maintenance of cellular homeostasis to the cellular response to stress, starvation, and infection. Although genetics and biochemical studies in yeast have identified many...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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更新日期:2018-02-01 00:00:00
abstract::Systemic sclerosis (SSc, scleroderma) is a devastating, immune-mediated, multisystem disorder characterized by microvasculature damage, circulating autoantibodies, and fibroblast activation, leading to massive fibrosis of skin, vessels, muscles, and visceral organs. Scleroderma causes disability and death as the resul...
journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-011-0288-2
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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更新日期:2009-11-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-011-0296-2
更新日期:2012-03-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-009-0164-5
更新日期:2009-09-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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更新日期:2020-02-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-013-0373-9
更新日期:2013-05-01 00:00:00
abstract::Aspergillus fumigatus is a saprotrophic filamentous fungus and also the most prevalent airborne fungal pathogen of humans. Depending on the host's immune status, the variety of diseases caused by A. fumigatus ranges from allergies in immunocompetent hosts to life-threatening invasive infections in patients with impair...
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pub_type: 杂志文章,评审
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更新日期:2015-03-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-014-0470-4
更新日期:2015-01-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0536-y
更新日期:2016-05-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-016-0606-9
更新日期:2017-01-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章
doi:10.1007/s00281-009-0158-3
更新日期:2009-07-01 00:00:00
abstract::The recent rise in obesity-related diseases, such as nonalcoholic fatty liver disease and its strong association with microbiota, has elicited interest in the underlying mechanisms of these pathologies. Experimental models have highlighted several mechanisms connecting microbiota to the development of liver dysfunctio...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-013-0404-6
更新日期:2014-01-01 00:00:00
abstract::Close association between chronic inflammation and cancer has been recently highlighted. Indeed, inflammatory bowel disease (IBD) has been strongly linked with an increased risk of development of colorectal cancer (CRC). Inflammatory cell-produced inflammatory mediators, such as proinflammatory cytokines and inducible...
journal_title:Seminars in immunopathology
pub_type: 杂志文章
doi:10.1007/s00281-012-0343-7
更新日期:2013-03-01 00:00:00
abstract::Checkpoint inhibitors blocking CTLA-4 (ipilimumab) and PD-1 (nivolumab, pembrolizumab) have transfigured our cancer treatment paradigm. However, these drugs can induce immune-related adverse events that share clinical and pathological characteristics with immune-mediated diseases. One of the most severe immune-related...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-016-0613-x
更新日期:2017-04-01 00:00:00
abstract::Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cer...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0526-0
更新日期:2016-05-01 00:00:00
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journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-012-0334-8
更新日期:2012-09-01 00:00:00
abstract::In autoinflammatory disorders, dysregulation of the innate immune response leads to an excessive cytokine release. The disease course is often characterized by high morbidity and mortality, treatment is mostly difficult and therapeutic options are limited. In most cases, life-long control of ongoing inflammation is ne...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-015-0501-9
更新日期:2015-07-01 00:00:00
abstract::Substantial epidemiologic data have shown an increased risk of cardiovascular (CV) disease in rheumatoid arthritis (RA) patients. Traditional CV risk factors may partly contribute to CV disease in RA; however, current evidence underlines the important role of inflammation in the pathogenesis of atherosclerosis and amp...
journal_title:Seminars in immunopathology
pub_type: 杂志文章,评审
doi:10.1007/s00281-017-0632-2
更新日期:2017-06-01 00:00:00