Abstract:
:Helicobacter pylori infection is an important factor for gastric carcinogenesis in human. In carcinogen-treated Mongolian gerbils, H. pylori infection enhances stomach carcinogenesis, while infection alone induced severe hyperplasia called heterotopic proliferative glands. A high-salt diet or early acquisition of the bacteria exacerbates inflammation and carcinogenesis. Oxygen radical scavengers or anti-inflammatory chemicals as well as eradication of H. pylori are effective to prevent carcinogenesis. H. pylori-associated inflammation induces intestinal metaplasia and intestinalization of stomach cancers independently. It is necessary to control cancer development not only in H. pylori-positive cases but also in H. pylori-negative metaplastic gastritis.
journal_name
Semin Immunopatholjournal_title
Seminars in immunopathologyauthors
Tsukamoto T,Toyoda T,Mizoshita T,Tatematsu Mdoi
10.1007/s00281-012-0357-1subject
Has Abstractpub_date
2013-03-01 00:00:00pages
177-90issue
2eissn
1863-2297issn
1863-2300journal_volume
35pub_type
杂志文章,评审abstract::Interleukin-9 is a cytokine classically related to type 2 immune responses whose cellular identity has been recently reevaluated to identify a new specialized T helper subset called Th9 and an innate source referred as innate lymphoid cell type 2. Over the past years, IL-9 has been associated with allergic responses, ...
journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
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abstract::Recent studies have identified novel lymphocyte subsets named innate lymphoid cells (ILCs) lacking antigen-specific receptors. ILCs are present in a wide variety of epithelial compartments and occupy an intermediate position between acquired immune cells and myeloid cells. ILCs are now classified into three groups: gr...
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
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journal_title:Seminars in immunopathology
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更新日期:2017-02-01 00:00:00
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journal_title:Seminars in immunopathology
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