Abstract：
:Type I and type II interferons (IFNα/β and IFNγ) are cytokines that play indispensable roles in directing myeloid cell activity during inflammatory and immune responses. Each IFN type binds a distinct receptor (IFNAR or IFNGR) to transduce signals that reshape gene expression and function of myeloid and other cell types. In the context of murine models and human bacterial infections, production of IFNγ generally promotes resistance while production of IFNα/β is associated with increased host susceptibility. Here, we review mechanisms of crosstalk between type I and II IFNs in myeloid cells and their impact on myeloid cell activation and anti-microbial function.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Crisler WJ,Lenz LLdoi
10.1016/j.coi.2018.05.014subject
Has Abstractpub_date
2018-10-01 00:00:00pages
35-41eissn
0952-7915issn
1879-0372pii
S0952-7915(18)30003-7journal_volume
54pub_type
杂志文章,评审abstract：:Systems biology strives to derive accurate predictive descriptions of complex systems such as innate immunity. The innate immune system is essential for host defense, yet the resulting inflammatory response must be tightly regulated. Current understanding indicates that this system is controlled by complex regulatory ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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abstract：:There has been great progress in understanding the alloresponse and the process of immune recovery after stem cell transplantation. Here, we highlight ways in which transplant outcome is determined by unique immunological features of the early post-transplant period that modulate the growth and function of the grafted...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2013.07.010
更新日期：2013-10-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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abstract：:The production of pathogenic autoantibodies in organ-specific autoimmune diseases is largely T cell dependent. For many of these diseases, the precise specificities and cytokine profiles of the T cells that respond to the corresponding autoantigens have now been identified. This knowledge has been exploited to treat s...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(00)00160-6
更新日期：2000-12-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2018.11.003
更新日期：2019-02-01 00:00:00
abstract：:There is a growing appreciation for the role for B cells in autoimmune disorders in which inflammation is driven by T cells, in addition to the well-established role for B cells in autoimmune disorders characterized by pathogenic auto-antibodies. Current information on tolerance checkpoints in B cells, B cell depletio...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2011.10.007
更新日期：2011-12-01 00:00:00
abstract：:Induction of antiviral immunity in vertebrates and invertebrates relies on members of the RIG-I-like receptor and Dicer families, respectively. Although these proteins have different size and domain composition, members of both families share a conserved DECH-box helicase domain. This helicase, also known as a duplex ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2015.01.009
更新日期：2015-02-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2010.12.013
更新日期：2011-04-01 00:00:00
abstract：:Self-antigen-MHC complexes expressed by thymic stromal cells serve as ligands for TCR-mediated positive and negative selection, resulting in a self-MHC-restricted, self-tolerant T cell repertoire. It has recently become apparent that thymic stromal cells differ in their accessibility to antigen as well as their abilit...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/s0952-7915(99)00069-2
更新日期：2000-04-01 00:00:00
abstract：:The innate immune system is comprised of a sophisticated network of recognition and effector molecules that act together to protect the host in the first minutes or hours of exposure to an infectious challenge. The mannose-binding lectin (MBL) is an evolutionary conserved circulating host defense protein that acts as ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2005.11.014
更新日期：2006-02-01 00:00:00
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2009.08.003
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2018.03.020
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journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2018.11.002
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abstract：:Human papillomaviruses (HPVs) have been associated with benign and malignant epithelial proliferations in either skin or mucosa. Two HPV oncogenic proteins, E6 and E7, are important in the induction and maintenance of cellular transformation and are co-expressed in the majority of HPV-containing carcinomas. Therefore,...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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abstract：:There is growing evidence that different antigen-presenting cells use specialized mechanisms for antigen uptake. Macropinocytosis and the activity of the mannose receptor have been identified as efficient mechanisms of antigen capture in dendritic cells. The mechanism of uptake determines the intracellular compartment...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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abstract：:Gene expression variation is critical for the normal development and physiology of immune cells. Using cDNA microarrays, a systematic, genomic-scale view of gene expression in immune cells at many stages of differentiation and activation can be obtained. From the high vantagepoint provided by this technology, the gene...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
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abstract：:Recent advances in the field of cellular therapy have focused on autologous T cells engineered to express a chimeric antigen receptor (CAR) against tumor antigens. Remarkable responses have been observed in patients receiving autologous CD19-redirected T cells for the treatment of B-lymphoid malignancies. However, the...
journal_title：Current opinion in immunology
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abstract：:A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in immune function of the skin with a particu...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2011.05.008
更新日期：2011-08-01 00:00:00
abstract：:The intestinal mucosa is continuously exposed to harmless exogenous antigens derived from food proteins and microbiota. Continuous surveillance by suppressive regulatory T cells prevents inflammatory responses to these antigens thereby maintaining intestinal homeostasis. The nature of the antigenic pressure varies at ...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2012.03.004
更新日期：2012-06-01 00:00:00
abstract：:Recent advances in mass spectrometry technology have facilitated detailed examination of MHC-II immunopeptidomes, for example the repertoires of peptides bound to MHC-II molecules expressed in antigen presenting cells. These studies have deepened our view of MHC-II presentation. Other studies have broadened our view o...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2016.03.004
更新日期：2016-06-01 00:00:00
abstract：:While remarkable progress has been made using genetically altered mice to understand the importance of different cytokines in protecting against experimental infections or co-infections, an examination of the opportunistic infections that occur during HIV infection of humans does not yet show a clear picture of cytoki...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/0952-7915(94)90138-4
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abstract：:Mycobacterium tuberculosis is an enormously successful human pathogen that can infect its host for decades without causing clinical disease, only to reactivate when host immunity is compromised. A normal immune response thus contains bacterial spread without inducing sterilizing immunity, therefore benefitting both ho...
journal_title：Current opinion in immunology
pub_type： 杂志文章,评审
doi：10.1016/j.coi.2011.06.002
更新日期：2011-08-01 00:00:00
