Notch signaling in T- and B-cell development.

abstract：:Cancer results from a tumor cell intrinsic dysregulation of oncogenes, tumor suppressor and stability genes as well as from the avoidance of immunosurveillance. A complex network of cellular interactions allows one to mount cognate anti-tumor immune responses. Recently, discoveries have been made regarding the links b...

journal_title：Current opinion in immunology

authors： Ghiringhelli F,Apetoh L,Housseau F,Kroemer G,Zitvogel L

更新日期：2007-04-01 00:00:00

abstract：:The adoptive transfer of T cells isolated or engineered to have specificity for diseased cells represents an ideal approach for the targeted therapy of human viral and malignant diseases. The therapeutic potential of adoptive T cell therapy for infections and cancer was demonstrated in rodent models long ago, but the ...

journal_title：Current opinion in immunology

authors： Berger C,Turtle CJ,Jensen MC,Riddell SR

更新日期：2009-04-01 00:00:00

abstract：:Vaccines have been developed and deployed against several important bacterial pathogens of humans, including Neisseria meningitidis, Bordetella pertussis, Streptococcus pneumoniae and Mycobacterium tuberculosis. These vaccines are generally considered a successful public health measure and are effective at controlling...

journal_title：Current opinion in immunology

authors： Barnett TC,Lim JY,Soderholm AT,Rivera-Hernandez T,West NP,Walker MJ

更新日期：2015-10-01 00:00:00

abstract：:While remarkable progress has been made using genetically altered mice to understand the importance of different cytokines in protecting against experimental infections or co-infections, an examination of the opportunistic infections that occur during HIV infection of humans does not yet show a clear picture of cytoki...

journal_title：Current opinion in immunology

authors： Mosier DE

更新日期：1994-08-01 00:00:00

abstract：:Recent findings indicate that activated T lymphocytes, showing restricted T-cell receptor repertoire and a Th1-like profile of cytokine production, are responsible for macrophage activation and release of inflammatory cytokines, toxic oxygen metabolites and nitric oxide, which initiate and maintain the transmural inte...

journal_title：Current opinion in immunology

authors： Romagnani P,Annunziato F,Baccari MC,Parronchi P

更新日期：1997-12-01 00:00:00

abstract：:Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is respon...

journal_title：Current opinion in immunology

authors： Boss JM

更新日期：1997-02-01 00:00:00

abstract：:Neurodegenerative diseases, such as Parkinson's and Alzheimer's, affect millions of people and pose major personal and socioeconomic burdens. The causes of neurodegeneration are mostly unknown, although current efforts have described an autoimmune aspect to these diseases. Here we discuss recent findings that shed lig...

journal_title：Current opinion in immunology

authors： Lindestam Arlehamn CS,Garretti F,Sulzer D,Sette A

更新日期：2019-08-01 00:00:00

abstract：:Infection with helminths has been associated with lower rates of asthma and other allergic diseases. This has been attributed, in part, to the ability of helminths to induce regulatory T cells that suppress inappropriate immune responses to allergens. Recent compelling evidence suggests that helminths may promote regu...

journal_title：Current opinion in immunology

authors： Logan J,Navarro S,Loukas A,Giacomin P

更新日期：2018-10-01 00:00:00

abstract：:Dendritic cells (DC) are heterogenous, comprising several subpopulations of migratory and lymphoid-organ-resident types. Recent studies addressing the role of each subset in antigen presentation in vivo have revealed a complex division of labor within the DC network. In addition to CD8(+) DC, migratory lung or dermal ...

journal_title：Current opinion in immunology

authors： Segura E,Villadangos JA

更新日期：2009-02-01 00:00:00

abstract：:Simply detecting the presence or absence of Foxp3, a transcription factor characteristic of naturally occurring CD4+ CD25+ regulatory T cells (Tregs), now appears of minimal value in predicting the outcome of immunologic responses, since dividing human CD4+ effector T cells can induce Foxp3 without attaining repressiv...

journal_title：Current opinion in immunology

authors： Tao R,de Zoeten EF,Ozkaynak E,Wang L,Li B,Greene MI,Wells AD,Hancock WW

更新日期：2007-10-01 00:00:00

abstract：:V(D)J recombination not only comprises the molecular mechanism that insures diversity of the immune system but also constitutes a critical checkpoint in the developmental program of B and T lymphocytes. The analysis of human patients with severe combined immune deficiency (SCID) has enabled (and will enable in the fut...

journal_title：Current opinion in immunology

authors： de Villartay JP,Poinsignon C,de Chasseval R,Buck D,Le Guyader G,Villey I

更新日期：2003-10-01 00:00:00

abstract：:Two years ago, T helper cells, including Th1, Th2 and Th17 cells, were considered to be the most significant sources of cytokine during the orchestration of immune responses in the lung. Following the discovery of innate lymphoid cells, we now know that these previously unappreciated cytokine-secreting cells, includin...

journal_title：Current opinion in immunology

authors： Scanlon ST,McKenzie AN

更新日期：2012-12-01 00:00:00

abstract：:During the first week after sexual exposure to HIV, HIV infection does not appear to trigger a strong innate immune response. Here we describe some recent studies that show that HIV may avoid triggering antiviral innate immune responses by not replicating efficiently in dendritic cells and by avoiding detection in inf...

journal_title：Current opinion in immunology

authors： Yan N,Lieberman J

更新日期：2011-02-01 00:00:00

abstract：:A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in immune function of the skin with a particu...

journal_title：Current opinion in immunology

authors： Vukmanovic-Stejic M,Rustin MH,Nikolich-Zugich J,Akbar AN

更新日期：2011-08-01 00:00:00

abstract：:Macrophages specifically engulf apoptotic cells but not healthy cells. Phosphatidylserine (PtdSer) is localized at the inner leaflet of plasma membranes as a result of the action of flippases (ATP11A and 11C). When cells undergo apoptosis, caspase 3 cleaves and inactivates the flippases, while simultaneously cleaving ...

journal_title：Current opinion in immunology

authors： Nagata S,Segawa K

更新日期：2020-08-24 00:00:00

abstract：:Physiological cell death, which occurs as a continuous byproduct of cellular turnover, is non-immunogenic or even tolerogenic, thereby avoiding autoimmunity. By contrast, cancer cell death elicited by radiotherapy and some chemotherapeutic agents such as anthracyclines is immunogenic. Recent data suggest that innate a...

journal_title：Current opinion in immunology

authors： Tesniere A,Apetoh L,Ghiringhelli F,Joza N,Panaretakis T,Kepp O,Schlemmer F,Zitvogel L,Kroemer G

更新日期：2008-10-01 00:00:00

abstract：:The germinal center (GC) is an important anatomical site for the development of high affinity antibodies during T-cell dependent B cell responses. Although the importance of the GC response to humoral immunity is well known, much remains to be elucidated about GC induction, maintenance and regulation. Recent studies e...

journal_title：Current opinion in immunology

authors： Cozine CL,Wolniak KL,Waldschmidt TJ

更新日期：2005-06-01 00:00:00

abstract：:Peptide-MHC interactions govern the fate of T cells in the thymus and the peripheral T cell repertoire. Recent progress has involved investigating how different peptides influence T cell selection and mature T cell function and the subsequent implications for tolerance and autoimmunity. ...

journal_title：Current opinion in immunology

authors： Ohashi PS

更新日期：1996-12-01 00:00:00

abstract：:Malaria remains one of the greatest impediments to development in many tropical regions of the world. Understanding host immune responses to malaria parasites is crucial for the effective design and implementation of new vaccines and drugs. Recent research has seen the identification of the first pattern recognition r...

journal_title：Current opinion in immunology

authors： Engwerda CR,Good MF

更新日期：2005-08-01 00:00:00

abstract：:Activated T cells undergo metabolic reprogramming which promotes glycolytic flux and lactate production as well as elevated production of lipids, proteins, nucleic acids and other carbohydrates (i.e. induction of biomass) even in the presence of oxygen. Activated T cells show induced expression of, among other things,...

journal_title：Current opinion in immunology

authors： Maciolek JA,Pasternak JA,Wilson HL

更新日期：2014-04-01 00:00:00

abstract：:Immunity to intracellular pathogens and cancer relies on the generation of robust CD8(+) T cell effector responses as well as the establishment of immunological memory. During a primary immune response CD8(+) T cells experience diverse extracellular environmental cues and cell-cell interactions that trigger downstream...

journal_title：Current opinion in immunology

authors： Thaventhiran JE,Fearon DT,Gattinoni L

更新日期：2013-06-01 00:00:00

abstract：:A diverse B cell repertoire is essential for an effective immune response. Not only to provide a variety of antibodies to recognise the multiplicity of likely pathogen challenge, but also because B cells are important regulators of the immune response. In addition to their excellent capabilities as antigen presenting ...

journal_title：Current opinion in immunology

authors： Dunn-Walters DK,Ademokun AA

更新日期：2010-08-01 00:00:00

abstract：:Antigens from a wide variety of pathogens have been identified as members of conserved heat-shock protein families, sharing upwards of 50% amino acid identity with corresponding host-cell proteins. Analysis of the responses to these conserved antigens may provide insights into regulation of the immune system during in...

journal_title：Current opinion in immunology

authors： Young DB

更新日期：1992-08-01 00:00:00

abstract：:Somatic mutations in the genome represent one of the major drivers of malignancy. However, non-synonymous mutations are also a source of mutated peptides that are presented by HLA molecules to induce protective CD4 and CD8 T cell responses. Consistent with this notion, the mutation burden of a tumor is correlated with...

journal_title：Current opinion in immunology

authors： Schumacher TN,Hacohen N

更新日期：2016-08-01 00:00:00

abstract：:The intestinal mucosa is continuously exposed to harmless exogenous antigens derived from food proteins and microbiota. Continuous surveillance by suppressive regulatory T cells prevents inflammatory responses to these antigens thereby maintaining intestinal homeostasis. The nature of the antigenic pressure varies at ...

journal_title：Current opinion in immunology

authors： Veenbergen S,Samsom JN

更新日期：2012-06-01 00:00:00

abstract：:Distinctions between tumor necrosis factor, TNF-alpha, and lymphotoxin, TNF-beta, have previously been based on the differences between their protein sequences, biological activity, and molecular regulation. In the past year, elucidation of the molecular nature of the two molecules and the interactions with common rec...

journal_title：Current opinion in immunology

authors： Ruddle NH

更新日期：1992-06-01 00:00:00

abstract：:A little more than a decade after the explosion of research into recombinant live-attenuated or replication-deficient viruses as vaccine platforms, many viral vector-based vaccines have been licensed for animals. Progress has been slower for humans but 2011 will see the licensure of the first viral-vectored vaccine fo...

journal_title：Current opinion in immunology

authors： Rollier CS,Reyes-Sandoval A,Cottingham MG,Ewer K,Hill AV

更新日期：2011-06-01 00:00:00

abstract：:Not surprisingly, most of the publications on enzyme immunoassays or latex agglutination tests in 1990 have been applications for specific antigens or antibodies. Nevertheless, a large number of studies of considerable interest to all users have been reported. In this short review, we have chosen to highlight investig...

journal_title：Current opinion in immunology

authors： Tijssen P,Adam A

更新日期：1991-04-01 00:00:00

abstract：:The activation of T lymphocytes is initiated by the binding of MHC-peptide complexes on antigen-presenting cells to MHC-restricted, peptide specific TCRs. Significant progress has recently been made in understanding the structure of the TCR and in the direct quantitative examination of the primary binding interactions...

journal_title：Current opinion in immunology

authors： Margulies DH

更新日期：1997-06-01 00:00:00

abstract：:Over the past year, we have witnessed the discovery of further virus immuno-evasins--proteins that alter the host immune response. Although many of these factors have been described over the past decade, the structural basis underlying their biology has lagged behind. Structural data have now been obtained for several...

journal_title：Current opinion in immunology

authors： Gewurz BE,Gaudet R,Tortorella D,Wang EW,Ploegh HL

更新日期：2001-08-01 00:00:00