Abstract:
:A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in immune function of the skin with a particular emphasis on how alterations in the interaction between cells involved in innate and adaptive immunity leads to decreased cutaneous antigen-specific T cell immunosurveillance.
journal_name
Curr Opin Immunoljournal_title
Current opinion in immunologyauthors
Vukmanovic-Stejic M,Rustin MH,Nikolich-Zugich J,Akbar ANdoi
10.1016/j.coi.2011.05.008subject
Has Abstractpub_date
2011-08-01 00:00:00pages
525-31issue
4eissn
0952-7915issn
1879-0372pii
S0952-7915(11)00065-3journal_volume
23pub_type
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